Abstract: A folding knife includes a handle portion and a blade pivotally coupled to the handle portion for pivoting movement between an open position and a closed position. The knife can include a locking mechanism that retains the blade against pivoting movement when it is in the open position. In particular embodiments, the blade is coupled to the handle portion such that the application of pressure to the blade in a predetermined direction causes displacement of blade relative to the handle portion in the plane within which the blade pivots. The displacement of the blade relative to the handle portion is effective to release the blade from the locking mechanism and allow the blade to be pivoted to the closed position.