Abstract: The present disclosure relates to the field of biomedicine, and in particular, to an improved mutant of a respiratory syncytial virus (RSV) fusion (F) protein and uses thereof. The mutant can form a trimeric structure without introducing a heterologous trimerization domain. Meanwhile, through mutation designs such as releasing internal electrostatic repulsion, deleting the furin cleavage site, truncating the C-terminal domain, and introducing interchain disulfide bonds, the protein is stabilized in the pre-fusion conformation and exhibits enhanced stability. The mutant in the present disclosure is highly immunogenic when used as a vaccine or a vaccine component and can induce the production of a high level of neutralizing antibodies in the immunized animal, which can be used in the preparation of a vaccine for the prevention or treatment of RSV infection, and can also be used as a reagent for the detection of RSV.

Abstract: Embodiments of the present disclosure provide a display panel and a display apparatus. The display panel includes: a display region and at least one non-display region adjacent to the display region; a boundary between the at least one non-display region and the display region has a curve part; the display panel includes pixels, including first pixels and second pixels; the pixels include sub-pixels; each first pixel includes: at least one first sub-pixel opening region corresponding to at least one sub-pixel and located in the display region, at least one first sub-pixel opening region in each first pixel is adjacent to the curve part, and a shape of at least part of the at least one first sub-pixel opening region adjacent to the curve part is non-rectangular; and each second pixel is located in the display region, each second pixel includes a second sub-pixel opening region corresponding to a sub-pixel.

Abstract: The present disclosure relates to the field of biomedicine, and in particular, to an improved mutant of a respiratory syncytial virus (RSV) fusion (F) protein and uses thereof. The mutant can form a trimeric structure without introducing a heterologous trimerization domain. Meanwhile, through mutation designs such as releasing internal electrostatic repulsion, deleting the furin cleavage site, truncating the C-terminal domain, and introducing interchain disulfide bonds, the protein is stabilized in the pre-fusion conformation and exhibits enhanced stability. The mutant in the present disclosure is highly immunogenic when used as a vaccine or a vaccine component and can induce the production of a high level of neutralizing antibodies in the immunized animal, which can be used in the preparation of a vaccine for the prevention or treatment of RSV infection, and can also be used as a reagent for the detection of RSV.

Abstract: A display panel and a display device are disclosed. The display panel includes: first pixels, second pixels and first pixel groups; each first pixel group includes a third pixel, and each first pixel includes a first sub-pixel opening region; each second pixel includes a second sub-pixel opening region; each third pixel includes a third sub-pixel opening region; a first ratio of an area of the first sub-pixel opening region to an area of a sub-pixel corresponding to the first sub-pixel opening region in a display region is less than a second ratio of an area of the second sub-pixel opening region to an area of a sub-pixel in the second pixel; a third ratio of an area of the third sub-pixel opening region to an area of a sub-pixel in the third pixel is not less than the first ratio; and the third ratio is less than the second ratio.

Abstract: A light control apparatus, a passive light-emitting image source and a head-up display system are provided. The head-up display system includes a light source, a collimator element, a light concentrator element, a diffuser element, a liquid crystal panel and a transflective reflection device for displaying; the collimator element is configured to adjust an exit direction of light emitted by the light source into a preset angle range; the light concentrator element is configured to concentrate the light emitted by the light source; the diffuser element is configured to diffuse the light emitted by the light source; the liquid crystal panel is configured to convert the light emitted by the light source into imaging light, and allow the imaging light to be incident on the reflection device for displaying; and the reflection device for displaying is configured to reflect the imaging light to a preset region.

Abstract: A head-up display system, an active light-emitting image source, a head-up display and a motor vehicle. The head-up display system includes a plurality of light sources arranged according to a predetermined rule; a micro-lens array including a plurality of micro-lenses, wherein each micro-lens corresponds to one or more light sources and adjusts directions of chief light of light emitted by the one or more light sources corresponding thereto, and the micro-lens array converges chief light of light emitted by the plurality of light sources so that chief light of light after being exited from the micro-lens array is directed to a predetermined range; and a reflector device for displaying at a side, away from the light sources, of the micro-lens array, and configured to emit light to an observation region.

Abstract: The display panel comprises: a plurality of pixels arranged in an array. Each pixel comprises a plurality of subpixels. The plurality of pixels arranged in an array comprise: a plurality of pixel rows. Each pixel row comprises a plurality of subpixels arranged in a first direction. The plurality of pixel rows extend in a second direction. The first direction intersects with the second direction. The display panel comprises: a first array substrate and a first opposing substrate arranged opposite to each other, and a first liquid crystal layer located between the first array substrate and the first opposing substrate. The first array substrate comprises: a plurality of first driving transistors arranged in an array. At least one pixel is arranged between two adjacent first driving transistors in the first direction. The first opposing substrate comprises: a plurality of light shielding portions in one-to-one correspondence to the first driving transistors.

Abstract: An optical computing topology structure configured to implement large-scale adjustment of a topology structure for different application scenarios. The optical computing topology structure includes a first physical medium, a spatial light modulator, and a second physical medium. The first physical medium, the spatial light modulator, and the second physical medium are sequentially connected. The first physical medium is configured to mix an input optical field, to implement a fully connected topology of the input optical field, to obtain a to-be-modulated optical field. The spatial light modulator is configured to modulate an optical field parameter of the to-be-modulated optical field to obtain a to-be-output optical field. The second physical medium is configured to mix the to-be-output optical field, to implement a fully connected topology of the to-be-output optical field, to obtain an output optical field.

Abstract: A display device, a head-up display and a transportation equipment are provided. In the display device, a first image source includes a first display area; a refraction element is configured to refract image light emitted from at least partial region of the first display area; the image light refracted by the refraction element is reflected by a first reflection element and propagated to an observation area to form a first virtual image; along a direction from a first end of the at least partial region to a second end of the at least partial region, an optical distance of at least part of the image light emitted from the at least partial region between a light incident surface of the refraction element and a light exiting surface of the refraction element gradually decreases.

Abstract: A protein inhibitor or degrading agent, a pharmaceutical composition comprising same and a pharmaceutical use. Provided are a compound represented by general formula (I), and a pharmaceutical composition containing same. Also disclosed are an application of the compound of the general formula as a protein inhibitor and/or a protein degrading agent and a pharmaceutical use.

Abstract: A display panel, a manufacturing method therefor, and a display device. The display panel comprises a display substrate and an opposite substrate opposite with each other, wherein both the display substrate and the opposite substrate cover the display region and the selected frame region; a liquid crystal layer between the display substrate and the opposite substrate, wherein the liquid crystal layer is at least located in the display region; a first polarizer on one side of the opposite substrate facing away from the liquid crystal layer, wherein the first polarizer covers the display region and the selected frame region; and a second polarizer on one side of the display substrate facing away from the liquid crystal layer.

Abstract: Disclosed is an underwater acoustic communication system based on a filter bank joint sub-carrier multidimensional index modulation and a method thereof. The system includes a transmitting terminal and a receiving terminal, the method is: conducting a joint index modulation at the transmitting terminal, firstly selecting an activated prototype pulse index by using a part of bits of a FBMC symbol, grouping the remaining transmitted information bits and all sub-carriers; using a part of the bits in each group to select the activated sub-carrier index, modulating the remaining bits to the activated sub-carriers by a constellation symbol mapping, forming a transmission signal after a filter bank modulation; and demodulating three parts of transmitted bits at a receiving terminal after an action of underwater acoustic channel, and recovering the original data bits by combining each part of decoding results.

Abstract: Disclosed is an underwater acoustic communication system based on a filter bank joint sub-carrier multidimensional index modulation and a method thereof. The system includes a transmitting terminal and a receiving terminal, the method is: conducting a joint index modulation at the transmitting terminal, firstly selecting an activated prototype pulse index by using a part of bits of a FBMC symbol, grouping the remaining transmitted information bits and all sub-carriers; using a part of the bits in each group to select the activated sub-carrier index, modulating the remaining bits to the activated sub-carriers by a constellation symbol mapping, forming a transmission signal after a filter bank modulation; and demodulating three parts of transmitted bits at a receiving terminal after an action of underwater acoustic channel, and recovering the original data bits by combining each part of decoding results.

Abstract: An electronic cigarette includes a cigarette body housing and a MEMS sensor located in the cigarette body housing. The MEMS sensor includes a shell with a receiving cavity, a MEMS Die with a back cavity received in the receiving cavity, an ASIC Die located in the receiving cavity and electrically connected to the MEMS Die, a first waterproof breathable membrane fixed to the shell and completely covering the first acoustic hole, and a second waterproof breathable membrane fixed to the shell and completely covering the second acoustic hole. The shell includes a first acoustic hole and a second acoustic hole penetrating the shell and communicating with the receiving cavity and an outside. Compared with the related art, the MEMS sensor disclosed by the present disclosure provides a MEMS Die with good performance.

Abstract: An electronic cigarette, including cigarette housing and micro-electromechanical system (MEMS) airflow sensor received in the cigarette housing. The MEMS airflow sensor includes a printed circuit board (PCB), an upper cover that covers PCB and encloses a receiving space together with PCB, and application specific integrated circuit (ASIC) chip and an MEMS chip with back cavity that are fixed to PCB and electrically connected to each other. The upper cover is provided with first sound hole passing therethrough. A side of PCB close to the upper cover and a side of PCB away from the upper cover are respectively provided with an upper metal layer and a lower metal layer that are exposed to a surface of PCB and are electrically connected to each other. A projection of ASIC chip on PCB at least partially falls within a range of the upper metal layer.

Abstract: A display panel and a display device are disclosed. The display panel includes: first pixels, second pixels and first pixel groups; each first pixel group includes a third pixel, and each first pixel includes a first sub-pixel opening region; each second pixel includes a second sub-pixel opening region; each third pixel includes a third sub-pixel opening region: a first ratio of an area of the first sub-pixel opening region to an area of a sub-pixel corresponding to the first sub-pixel opening region in a display region is less than a second ratio of an area of the second sub-pixel opening region to an area of a sub-pixel in the second pixel; a third ratio of an area of the third sub-pixel opening region to an area of a sub-pixel in the third pixel is not less than the first ratio; and the third ratio is less than the second ratio.

Abstract: An electronic cigarette includes an atomizer, an e-liquid cavity, and an airflow sensing device. The airflow sensing device includes a first circuit board, a MEMS airflow sensor, and a main control IC. A second control board includes a first bonding pad and a second bonding pad. The second bonding pad is disposed around the first bonding pad. The first bonding pad includes a first pin and the second bonding pad includes a second pin. Since the first bonding pad is surrounded and sealed by the second bonding pad, the first pin is electrically connected to a capacitance detection port of the main control IC, and the second pin is grounded, condensate is prevented from contacting the first pin, thus preventing the condensate from flowing through a capacitance detection circuit. The main control IC does not detect an increase in capacitance value, which prevent the electronic cigarette from self-starting.