Abstract: The present invention discloses a pyrimidine heterocyclic compound, and a preparation method and medical use thereof. Specifically, the present invention discloses a pyrimidine heterocyclic compound with a structure shown in Formula (A) or a pharmaceutically acceptable salt thereof (groups are each defined in the specification), a pharmaceutical composition comprising the compound, and use of the compound in treatment of cell proliferative diseases (such as cancers).

Abstract: A method includes receiving a first call request sent by a tenant, determining that the call request corresponds to a first service deck, where the first service deck comprises a first service grid and a second service grid, and where the first service grid and the second service grid store same data of a cloud service, and when the first service grid is faulty, forwarding the first call request to the second service grid in a normal working state.

Abstract: A method for preparing a self-supporting substrate includes: preparing a thin film base structure including a first substrate layer, a thin film layer and a second substrate layer stacked in sequence; removing the first substrate layer from the thin film layer; continuing to grow a material the same as that of the thin film layer on a side of the thin film layer far away from the second substrate layer to prepare a thick film layer; and removing the second substrate layer from the thick film layer and remaining the thick film layer. In the method, a thin film may be grown on a substrate that has a larger diameter, and a thinness of the thin film will not cause the thin film and/or the substrate to crack. Therefore, a thin film that has a large diameter may be obtained so as to obtain a large-sized self-supporting thick film substrate.

Abstract: The embodiments of the present application provide an instruction retirement unit, an instruction execution unit, and a related apparatus and method. The instruction retirement unit includes: a reception subunit, configured to receive a completion request signal; an arbitration subunit, configured to send a completion permission signal to an instruction execution unit after determining that instructions to be completed can be completed, and store instruction completion information of the instructions to be completed into instruction buffer table entries in a buffer; and a retirement subunit, configured to perform, based on the instruction completion information stored in each of the instruction buffer table entries, retirement processing on instructions that have already been completed and have not been retired, and delete the instruction completion information of retired instructions from the instruction buffer table entries.

Abstract: An LED tube lamp includes a glass lamp tube, two end caps, an adhesive, an LED light strip, a plurality of LED light sources, a power supply, and a diffusion film. The glass lamp tube includes a main body region and two rear end regions. Each of the two end caps coupled to a respective rear end region by the adhesive. The LED light strip comprises a mounting region adhered to an inner circumferential surface of the glass lamp tube and a connecting region. The plurality of LED light sources are mounted on the mounting region. The power supply includes a circuit board separating from the LED light strip. The diffusion film is covering on an outer surface of the glass lamp tube. The connecting region, one of the rear end regions, the adhesive and one of the lateral wall are stacked sequentially in a radial direction of the glass lamp tube.

Abstract: The present invention relates to use of a benzisoselenazole compound in the preparation of a drug for the treatment of spinaglioma. By applying the benzisoselenazole compound, cell proliferation of the spinaglioma can be effectively inhibited at the cellular level, with an obvious dose dependence. The tumor growth of a tumor-bearing mouse can be effectively inhibited at the animal model level, and the survival period of the tumor-bearing mouse can be prolonged.

Abstract: Provided is an efficient and energy-saving building slurry stirring device. The device includes a grouting assembly, which includes a base, a storage tank, a discharge pipe, a grouting pump and a control box. The storage tank is arranged at the top of the base, the discharge pipe is located at one side of the storage tank, the grouting pump is arranged on the discharge pipe, and the control box is fixed to the top of the base. When the fluidity of a grouting material in the storage tank is reduced due to solidification, the stirring assembly can stir the grouting material in the storage tank. Then, the stirring assembly stops stirring the grouting material to save energy. After the grouting is completed, an inner wall of the storage tank can be cleaned by the stirring assembly.

Abstract: Compositions comprise statistically random heteropolymers complexed with active proteins, and are formulated and used in stimuli-responsive materials and nanoreactors composed of proteins and synthetic materials.

Abstract: A LED lighting device, comprising: a base which has a bottom plate and a side wall, a cavity being formed between the bottom plate and the side wall; an optical component which covers one side of the base in a light-emitting direction of the LED lighting device; and a light source which is provided in the cavity of the base and comprises a circuit board and several LED arrays, the LED arrays comprising LED lamp beads fixed on the circuit board. The optical component comprises an optical unit, and the optical unit comprises a plurality of first optical components and a plurality of second optical components which correspond to the first optical components.

Abstract: An example optical-electrical apparatus includes an optical-to-electrical conversion circuit, an electrical signal processing circuit, an electrical signal interface circuit, and a status detection circuit. The optical-to-electrical conversion circuit is configured to convert an optical signal into an electrical signal. The electrical signal processing circuit is configured to output a first parameter of the optical signal based on the electrical signal, where the first parameter includes an optical polarization parameter. The status detection circuit is configured to obtain status information of the optical signal based on the first parameter, where the status information of the optical signal is output via the electrical signal interface circuit.

Abstract: A neutron capture therapy system is provided, which may prevent a material of a beam shaping assembly from deformation and damaged, and improve the flux and quality of neutron sources. A boron neutron capture therapy system (100) includes a neutron generating device (10) and a beam shaping assembly (20). The neutron generating device (10) includes an accelerator (11) and a target (T). A charged particle beam (P) generated by acceleration of the accelerator (11) acts with the target (T) to generate neutrons. The neutrons form a neutron beam (N). The neutron beam (N) defines a main axis (X). The beam shaping assembly (20) includes a support part (21) and a main part (23) filled within the support part (21).

Abstract: An LED tube light includes a tube, two end caps, two power supply modules and a LED light strip. The end caps are separately disposed on two ends of the tube. The power supply module includes a power circuit board and electronic components, and is located in at least one of two receiving spaces formed by the tube and the end caps. The LED light strip is disposed in the tube and includes a lamp board and LED light sources. The LED light sources are disposed on the lamp board. The lamp board has a freely extending end portion and a lighting portion. The freely extending end portion is connected with the power supply module, and forms a folding zone. A portion of the freely extending end portion in the folding zone has a first bending portion and a second bending portion.

Abstract: Disclosed are an imidazothiazole derivative, a preparation method therefor, and an application thereof. The imidazothiazole derivative has a structure represented by formula (I): R1 and R3 are each independently selected from optionally substituted five-membered to six-membered heterocyclyl containing one to two nitrogen atoms, and R2 and R4 are each independently selected from optionally substituted aryl or heteroaryl. The imidazothiazole derivative has good MNK inhibitory activity, excellent selectivity, and an excellent in vivo hypoglycemic effect, and has a wide medicinal background.

Abstract: An LED lamp includes: a lamp neck having a circular cross-section along a central axis; a lamp head and a sleeve connected to lamp neck; a heat sink comprising a plurality of fins, sleeving over the sleeve and connecting to the lamp neck; a power source comprising a power board and a plurality of electronic components mounted thereon disposed in a chamber formed by the lamp neck and the sleeve; a light board comprising an opening at center portion and disposed at second end of the heat sink; and a plurality of LED chips mounted on the light board; wherein the chamber and the opening of the light board defines a first heat dissipating channel, the plurality of fins and the opening of the light board defines a second heat dissipating channel, the first heat dissipating channel and the second heat dissipating channel share the opening of the light board.

Abstract: A vascular access system which may be configured for blood draw may include a housing, which may include a distal end, a proximal end, and a slot disposed between the distal end and the proximal end. The slot may include a notch. The vascular access system may include a cannula hub, which may be disposed within the housing and movable with respect to the slot. The cannula hub may include a tab extending through the slot. The vascular access system may include a cannula extending distally from the cannula hub. In response to the tab being disposed within the notch, a distal tip of the cannula may be disposed within the housing. In response to advancing the tab along the slot to a distal end of the slot, the distal tip of the cannula is disposed distal to the distal end of the housing.

Abstract: A process system of a follower fixture for tank moving support is provided and includes a conveying table slidably provided with a bearing platform through a screw slide rail assembly and provided with an outer frame assembly; a lifting platform is slidably installed in the outer frame assembly; positions of the lifting platform and the bearing platform are corresponded up and down; the outer frame assembly is slidably provided with a robot component; both sides of the conveying table are provided with loading platforms; workpieces are placed on one loading platform, and a fixture system is placed on the other loading platform; the fixture system and the workpieces are both placed in the moving range of the robot component, and positions of the fixture system and the workpieces are corresponded. problems including processing flexibility cannot be realized can be solved.

Abstract: This application relates to the field of lighting, and discloses an LED filament. The LED filament includes an LED chip unit, a light conversion layer, and an electrode. The light conversion layer covers the LED chip unit and part of the electrode, and a color of a light emitted by the LED filament after lighting is different from a color of the light conversion layer. This application has the characteristics of uniform light emission and good heat dissipation effect.

Abstract: An LED lighting device includes a seat, an optical assembly and a light source. The seat has a baseplate and a sidewall. A chamber is formed between the baseplate and the sidewall. The optical assembly completely covers a light-emitting side of the LED lighting device. The light source is disposed in the chamber of the seat and includes multiple LED arrays. Each LED array includes an LED chip. The optical assembly includes an optical unit. The optical unit includes multiple first optical members and multiple second optical members corresponding to the first optical members. The LED arrays correspond to the first optical members. Each first optical member possesses an effect of light diffusion resulting from its own material property. Each second optical member includes one or more sets of optical walls. Each set of optical walls surrounds one of the first optical members.

Abstract: A LED lighting device, comprising: a base which has a bottom plate and a side wall, a cavity being formed between the bottom plate and the side wall; an optical component which covers one side of the base in a light-emitting direction of the LED lighting device; and a light source which is provided in the cavity of the base and comprises a circuit board and several LED arrays, the LED arrays comprising LED lamp beads fixed on the circuit board. The optical component comprises an optical unit, and the optical unit comprises a plurality of first optical components and a plurality of second optical components which correspond to the first optical components.