Abstract: Described are a number of aptamers that are specific to bind with peptidoglycan (“PGN”) with specificity over counter-targets lipopolysaccharides (“LPS”) and lipoteichoic acid (“LTA”), and associated methods.

Abstract: Described are a number of aptamers that are specific to bind with lipopolysaccharide (LPS), and associated methods.

Abstract: Described are a number of aptamers that are specific to bind with lipoteichoic acid (LTA), and associated methods.

Abstract: The present invention provides uses of a compound represented by formula A in the preparation of drugs for treating brain glioma and particularly glioblastoma. Particularly provided are uses of the compound represented by formula A in the preparation of drugs for treating expression of specific fusion protein. By means of the technical solution of the present invention, typing of brain glioblastoma can be implemented, a drug administration can be carried out for a specific patient group, and precise treatment can be implemented.

Abstract: An LED lighting device comprise a lamp cap; a case, connected to the lamp cap and having a cavity; a power supply disposed in the cavity of the case; a heat exchange unit comprises a first heat spreader and a second heat spreader, the heat exchange unit has a folded state and an expanded state, and the heat exchange unit can be switched between the folded state and the expanded state, the heat exchange unit has a width dimension A in the folded state and has a width dimension B in the expanded state, the width dimension A of the heat exchange unit in the folded state is less than the width dimension B of the heat exchange unit in the expanded state, and a light emission unit, the light emission unit and the heat exchange unit are connected to form a thermal conduction path, the light emission unit and the power supply are electrically connected.

Abstract: A substituted dihydropyrazole compound as shown in formula I, which compound has a selective inhibitory effect on RIPK1, and a pharmaceutically acceptable salt, a stereoisomer, a solvate or a prodrug thereof, wherein the definition of each group in the formula is detailed in the description. In addition is a pharmaceutical composition containing the compound, and the use thereof in the preparation of a drug for treating RIPK1-related diseases or conditions.

Abstract: A suitcase bottom shell and the suitcase having a bottom case are provided. The suitcase bottom shell includes a shell body; the shell body is provided with universal wheels and further provided with storage grooves; and the universal wheels are stored in the storage grooves. By arranging the storage grooves on the shell body, the universal wheels are stored in the storage grooves when the suitcase needs to be laid aside, and the universal wheels are taken out from the storage grooves when the suitcase needs to be used to achieve a stability as well as convenience and efficiency; by arranging limiting mechanisms, the universal wheels keep unfolded for sliding without being stored by mistake when the suitcase is in normal use, or keep stored without extending and sliding by accident when the suitcase is laid aside.

Abstract: The disclosure provides a catalyst system and a method for ethylene oligomerization using this. The catalyst system contains: ligand a, containing carbene groups of imidazole ring type; transition metal compound b, that is one of IVB˜VIII group metal compounds; activator c, that is a compound containing III A group metals; the ligand a contains at least one group as shown in general formula I: in which, bridging group A contains a main chain including alkyl, alkenyl, aryl groups or the combination of them and the first heteratom; E is a linear or cyclic group containing the second heteroatom; R is a hydrocarbyl group. The catalyst system is especially used for trimerization and tetramerization of ethylene. The catalyst system has high selectivity for 1-hexene and 1-octene, low selectivity for 1-butene and 1-C10+, and the total percent content of C6˜C8 linear ??-olefin in the product is more than 90% by mass.

Abstract: The present invention provides a microcrystalline glass product. The microcrystalline glass product includes the following components in percentage by weight: SiO2: 45-70%; Al2O3: 8-18%; Li2O: 10-25%; ZrO2: 5-15%; P2O5: 2-10%; and Y2O3: greater than 0 but less than or equal to 8%. Through reasonable component design, the microcrystalline glass and the microcrystalline glass product obtained in the present invention have excellent mechanical and optical properties and are suitable for electronic devices or display devices.

Abstract: A polypeptide magnetic nanoparticle, comprising: a specific targeting polypeptide and a magnetic nanoparticle. The amino acid sequence of the specific targeting polypeptide is VRRDAPRFSMQGLDA-X, and the C-terminal X thereof is a sequence of 5 to 20 amino acids. The amino acid in the amino acid sequence of C-terminal X is selected from one or more of: C, G, and N. The polypeptide magnetic nanoparticle can be used for CTC detection and molecular typing of various cancer types, including esophageal cancer, liver cancer, lung cancer, stomach cancer, bladder cancer, skin cancer, melanoma, breast cancer, colorectal cancer, cervical cancer, etc. Biomarkers of CTC molecular typing include PD-L1, HER2, ER, PR, AR, EGFR, VEGFR, CXCR4, etc. The polypeptide magnetic nanoparticle is helpful for CTC detection and the qualitative and semiquantitative analysis of expression levels of biomarkers at CTC level, thereby performing precise therapy such as targeted individualized targeted therapy or immunotherapy on patients.

Abstract: The present invention is directed to compounds according to Formula I as well as to stereoisomer, tautomer or pharmaceutically acceptable salts of such compounds. The invention also is directed to pharmaceutically acceptable compositions containing such compounds and associated methods for preparing and effect dose in treatment as well as the application in preparing medicine for preventing and/or treating cancers. The invention provides the novel derivatives which introduce methylenedioxy in the position of 10,11 and different groups in the position of 7. The derivatives of novel structure, and the raw materials are easily to obtain. In addition, the compounds in this invention have good cytotoxic activity in vitro and anti-tumor activity in vivo. Therefore, this kind of compounds have broad application foreground.

Abstract: An LED lamp comprises a lampshade, a base connected to the lampshade, a photoelectric module comprising a light source module and a power supply module disposed in an accommodating space formed between the lampshade and the base, the photoelectric module is detachably fixed to the base through a mounting portion.

Abstract: A method and a device for primary frequency modulation in new energy power generation are provided. An inverter performs a first power adjustment according to a p-f droop curve before receiving a power adjustment instruction sent by the power station controller, and performs a second power adjustment in response to the power adjustment instruction. Since the inverter performs the first power adjustment before responding to the power adjustment instruction sent by the power station controller, the response of the primary frequency modulation is speeded up, so that rapid control for the new energy generation power is achieved, thereby ensuring stable operation of a power grid for new energy power generation.

Abstract: A method for semiconductor film lift-off and substrate transfer is provided. It includes: preparing a semiconductor film-substrate structure including a first substrate layer, multiple seed crystal structures and a semiconductor film layer stacked in that order, and holes are formed among the multiple seed crystal structures and communicated with one another; lifting-off the multiple seed crystal structures and the semiconductor film layer from the first substrate layer; and bonding a side of the multiple seed crystal structures facing away from the semiconductor film layer with a second substrate layer to complete processes of the semiconductor film lifting-off and the substrate transfer. The method can be compatible with various epitaxial substrate materials, and can also retain smooth surface of the device epitaxial layer film without affecting the subsequent process of growing other functional layers for preparing devices on the epitaxial layer film.

Abstract: Embodiments of the present disclosure provide an apparatus, comprising: one or more instruction executing circuitries, wherein each instruction executing circuitry of the one or more instruction executing circuitries is configured to execute an instruction of a corresponding instruction type, and an instruction scheduling circuitry that is communicatively coupled to the one or more instruction executing circuitries, the instruction scheduling circuitry is configured to: determine according to an instruction type of the instruction and a number of instructions that have been allocated to the one or more instruction executing circuitries, an instruction executing circuitry from the one or more instruction executing circuitries to schedule the instruction for execution, and allocated the instruction to the determined instruction executing circuitry.

Abstract: The present disclosure provides an array substrate and a manufacturing method of the array substrate, a display device. An array substrate comprises: a pixel array, each pixel in the pixel array having a pixel electrode; a transistor array, each transistor in the transistor array having a source electrode; and a connection electrode for electrically connecting the pixel electrode to a corresponding source electrode.

Abstract: The present disclosure discloses a method for fast determining a time-delay stability margin of a power system, which focuses on three steps, i.e., Jordan standardization, Taylor separation and Schur simplification, to reconstruct a new time delay system and reduce the system dimension. In this method, firstly, a time delay model is Jordan standardized; further, Taylor expansion is applied in a process for separating state variables with time delay from stage variables without time delay; then, balanced model reduction is realized by Schur simplification; and finally, a WSCC 3-generator-9-bus power system with multiple delays will be used to validate the proposed method via several typical criteria.

Abstract: The present disclosure provides a method and a catalyst for selective oligomerization of ethylene. The raw material for the catalyst consists of a dehydropyridine annulene-type ligand, a transition metal compound, and an organometallic compound in a molar ratio of 1:0.5-100:0.1-5000. The present disclosure also provides a method for selective oligomerization of ethylene accomplished by using the above-mentioned catalyst. The catalyst for selective oligomerization of ethylene has high catalytic activity, high selectivity for the target products 1-hexene and 1-octene, and low selectivity for 1-butene and 1-C10+.