Abstract: Disclosed in the present invention are a substituted heterocyclic compound containing an ?-ketone framework, and the use thereof, which relate to the field of medicinal chemistry. Specifically disclosed are a substituted heterocyclic compound containing an ?-ketone framework, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing these compounds, and the medical use thereof, and in particular, the use thereof as a fatty acid amide hydrolase (FAAH) inhibitor in the preparation of a drug for preventing or treating FAAH-related diseases, comprising inflammatory diseases, rheumatoid arthritis, hepatitis, hepatic fibrosis, autoimmune disease, pain, depression, pain and depression comorbidity, autism, social anxiety disorder, Tourette's syndrome, neurode-generative diseases, anxiety and post-traumatic stress disorder (PTSD), cannabinoid use disorders, drug withdrawal and anti-tumor treatment.

Abstract: A shear testing system and method of thermo-seepage-mechanical field and engineering disturbance coupling under deep and complex condition are provided. The shear testing system can be used in conjunction with an axial pressure application device to simplify the structure, save costs, and facilitate a triaxial confining pressure—temperature—axial pressure—torsional shear coupled test on a rock specimen. The shear testing system can achieve the following three purposes. First, the shear testing system can convert an axial pressure into a torsional shear force through a transmission mechanism of a power conversion assembly. Second, the shear testing system can apply an axial pressure to the rock specimen fixed between two specimen fixing heads, through a pressure shaft of an axial pressure mechanism. Third, the shear testing system can apply a triaxial confining pressure and a temperature field to the rock specimen.

Abstract: A system for regulating an environment within an operator cabin of a machine via a heating, ventilation, and air conditioning (HVAC) system includes a first sensor that generates a first signal of an amount of air pressure within the operator cabin, a second sensor that generates a second signal of an amount of carbon dioxide within the operator cabin, an air filtration element to direct pre-cleaned air into the operator cabin, an inlet valve disposed between the air filtration element and the HVAC system for controlling a flowrate of the pre-cleaned air to the HVAC system, and a controller. The controller actuates dynamic auto-control of the inlet valve to direct an optimally varying flowrate of the pre-cleaned air from the air filtration element to the HVAC system via the inlet valve to maximize a service life of the air filtration element.

Abstract: Disclosed are a new AXL-targeting monoclonal antibody and antibody-drug conjugate. Also disclosed is a method for preparing said antibody and antibody-drug conjugate. The AXL antibody of the present invention can bind with purified human AXL protein and multiple AXL on tumor cell surface with high effectiveness and high specificity. Said humanized antibody also has high affinity and low immunogenicity. Said AXL antibody-drug conjugate has markable performance against tumors having high AXL expression.

Abstract: A tissue factor (TF)-targeted antibody-drug conjugate (ADC) and a method for preparing the ADC. The ADC is capable of binding to TF antigen with high specificity, and has high affinity, low immunogenicity, high cytotoxicity, and significant anti-tumor activity.

Abstract: A tissue factor (TF)-targeted antibody-drug conjugate (ADC) and a method for preparing the ADC. The ADC is capable of binding to TF antigen with high specificity, and has high affinity, low immunogenicity, high cytotoxicity, and significant anti-tumor activity.

Abstract: A method, a component, and an electronic device relating to the field of industrial automation technology, particularly relating to the creation of a human machine interface, and are used for automatically creating an HMI of a system. The method for creating an HMI comprises: a first component of a system receives, via an HMI, a first command for creating an HMI for the system; the first component obtains, from each searched and found second component of the system an HMI resource of each of the second components; and the first component creates, on the basis of an HMI resource of the first component and the obtained HMI resource from each of the second components, the HMI for the system. One component of the system collects the HMI resource of another component of the system and creates the HMI for the whole system, providing a method for automatically creating the HMI for the system.

Abstract: Disclosed are an information providing method and system. In an embodiment, the method includes: acquiring product data and/or historical operation data; determining at least one feature description tag of an industrial product based upon the product data, and taking the at least one feature description tag of the industrial product as a feature of the industrial product; and/or determining at least one feature description tag of a user based upon the historical operation data, and taking the at least one feature description tag of the user as a feature of the user. The method further includes sending the feature of the industrial product and/or the feature of the user to a human-machine interactive device for display on a human-machine interactive interface. An embodiment further provides a reference suggestion for operative control of the industrial product by the user.

Abstract: The present disclosure provides an ultralow-glossiness, ultralow-temperature resistant ASA resin composition and preparation method thereof. The composition includes the following components in parts by weight: 20˜60 parts of an acrylonitrile-styrene-acrylate graft copolymer, 40˜80 parts of an acrylonitrile-styrene copolymer, 1˜20 parts of an ultralow-glossiness, low temperature resistant modifier, and 0.1˜5 parts of a processing aid. The ultralow-glossiness, low temperature resistant modifier includes a carrier copolymer, a fluorinated copolymer, a low-temperature flexibilizer, a coupling agent, fumed silica and an assistant.

Abstract: The present invention relates to dihydroquinoxaline bromodomain recognition protein inhibitor, preparation method and use thereof. The inhibitor of the present invention is compound represented by general formula (I), or stereoisomer, pharmaceutically acceptable salt, prodrug, solvate, hydrate and crystal form thereof. The definition of each substituent is as described in the description and claims. The compound represented by general formula (I) of the present invention may inhibit bromodomain recognition protein and may be used for preparing medicament which regulates the apparent state of cells and treats series of diseases and symptoms which are mediated by the bromodomain recognition protein.

Abstract: Disclosed are a new AXL-targeting monoclonal antibody and antibody-drug conjugate. Also disclosed is a method for preparing said antibody and antibody-drug conjugate. The AXL antibody of the present invention can bind with purified humanAXL protein and multiple AXL on tumor cell surface with high effectiveness and high specificity. Said humanized antibody also has high affinity and low immunogenicity. Said AXL antibody-drug conjugate has markable performance against tumors having high AXL expression.

Abstract: Please replace the original abstract paragraph with the following new paragraph. A mobile terminal includes a housing and a camera. The camera is rotatably coupled to the housing and configured for locking at a specified position. When the camera is locked at a first specified position, the camera is located inside the housing and one side of the camera is exposed outside the housing, and when the camera is locked at a second specified position, a lens of the camera is exposed outside the housing. The mobile terminal further includes a drive apparatus and a touch apparatus. The drive apparatus is configured to drive the camera to rotate, and the touch apparatus includes a touch sensor and a control chip. After receiving a touch signal from the touch sensor, the control chip controls the drive apparatus to drive the camera to rotate to the second specified position.

Abstract: A method is for executing an application in a cloud system. The method includes receiving a request from a first user for executing an application in the cloud system; receiving, from the first user, user data of the first user related to the execution of the requested application; storing the received user data in a first storage area of a computing environment of the cloud system; in the computing environment, executing the requested application based on the stored user data of the first user to obtain an execution result; and storing the execution result in a second storage area of the computing environment, the access permission of the first user to the first storage area being a write-only permission, and the access permission of the first user to the second storage area being a read-only permission. As such, data privacy protection and security can be provided in the cloud system.

Abstract: Provided in the present invention are a di-substituted maleic amide linker conjugated to an antibody and a preparation method and use thereof. In particular, the present invention conjugates a strongly cytotoxic active substance to a biomacromolecule through a class of new linkers. The class of linkers can selectively act simultaneously with disulphide chains, so as to greatly improve the substance homogeneity of a conjugate. The conjugate prepared by the linker of the present invention has a high inhibitory activity on a cell strain expressing the corresponding antigen. Also provided is a method for preparing the above-mentioned conjugate and the use.

Abstract: Please replace the original abstract paragraph with the following new paragraph. A mobile terminal includes a housing and a camera. The camera is rotatably coupled to the housing and configured for locking at a specified position. When the camera is locked at a first specified position, the camera is located inside the housing and one side of the camera is exposed outside the housing, and when the camera is locked at a second specified position, a lens of the camera is exposed outside the housing. The mobile terminal further includes a drive apparatus and a touch apparatus. The drive apparatus is configured to drive the camera to rotate, and the touch apparatus includes a touch sensor and a control chip. After receiving a touch signal from the touch sensor, the control chip controls the drive apparatus to drive the camera to rotate to the second specified position.

Abstract: The present disclosure provides an ultralow-glossiness, ultralow-temperature resistant ASA resin composition and preparation method thereof. The composition includes the following components in parts by weight: 20˜60 parts of an acrylonitrile-styrene-acrylate graft copolymer, 40˜80 parts of an acrylonitrile-styrene copolymer, 1˜20 parts of an ultralow-glossiness, low temperature resistant modifier, and 0.1˜5 parts of a processing aid. The ultralow-glossiness, low temperature resistant modifier includes a carrier copolymer, a fluorinated copolymer, a low-temperature flexibilizer, a coupling agent, fumed silica and an assistant.

Abstract: The present invention relates to dihydroquinoxaline bromodomain recognition protein inhibitor, preparation method and use thereof. The inhibitor of the present invention is compound represented by general formula (I), or stereoisomer, pharmaceutically acceptable salt, prodrug, solvate, hydrate and crystal form thereof. The definition of each substituent is as described in the description and claims. The compound represented by general formula (I) of the present invention may inhibit bromodomain recognition protein and may be used for preparing medicament which regulates the apparent state of cells and treats series of diseases and symptoms which are mediated by the bromodomain recognition protein.

Abstract: Provided in the present invention are a di-substituted maleic amide linker conjugated to an antibody and a preparation method and use thereof. In particular, the present invention conjugates a strongly cytotoxic active substance to a biomacromolecule through a class of new linkers. The class of linkers can selectively act simultaneously with disulphide chains, so as to greatly improve the substance homogeneity of a conjugate. The conjugate prepared by the linker of the present invention has a high inhibitory activity on a cell strain expressing the corresponding antigen. Also provided is a method for preparing the above-mentioned conjugate and the use.

Abstract: A method, a component, and an electronic device relating to the field of industrial automation technology, particularly relating to the creation of a human machine interface, and are used for automatically creating an HMI of a system. The method for creating an HMI comprises: a first component of a system receives, via an HMI, a first command for creating an HMI for the system; the first component obtains, from each searched and found second component of the system an HMI resource of each of the second components; and the first component creates, on the basis of an HMI resource of the first component and the obtained HMI resource from each of the second components, the HMI for the system. One component of the system collects the HMI resource of another component of the system and creates the HMI for the whole system, providing a method for automatically creating the HMI for the system.

Abstract: A tissue factor (TF)-targeted antibody-drug conjugate (ADC) and a method for preparing the ADC. The ADC is capable of binding to TF antigen with high specificity, and has high affinity, low immunogenicity, high cytotoxicity, and significant anti-tumor activity.