Abstract: Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, stereoisomer, isotopic form or prodrug thereof, wherein R1, L1, L2, L3, A1, A2, A3, A4, G1, G2, E, W, X, Y, Z, m, and n are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.

Abstract: A double-mirror focusing inside-beam powder-feeding laser-cladding device includes: first and second reflection beam splitters, a focusing lens, a vertical piping powder feeding device, and a collimated lens group. The first reflection beam splitter is disposed at a side of the collimated lens group; the second reflection beam splitter is disposed outside the first reflection beam splitter; the focusing lens is disposed at a side of the second reflection beam splitter facing away the collimated lens group; and the vertical piping powder feeding device is disposed at a side of the first reflection beam splitter facing away the collimated lens group. When the device is in use, a collimated beam is formed through the collimated lens group, and then reflected by the first and second reflection beam splitters to form an annular laser beam that can be focused by the focusing lens to form a light spot.

Abstract: An in-situ robot material-reducing processing method and system for a hydraulic turbine top cover are provided. The method includes: S1, obtaining frequency response data of an end of a cutter controlled by a robot by performing an impact hammer test; S2, obtaining a modal parameter of the end of the cutter controlled by the robot by using a modal analysis software; S3, obtaining a damping matrix [C] and a stiffness matrix [K] by using a free vibration equation of a damped system; S4, establishing a dynamic model of a three-degree-of-freedom robot processing system; S5, obtaining a milling force coefficient of the cutter by performing a calibration experiment; S6, solving a dynamic equation; S7, drawing a lobe diagram of flutter stability of a milling process performed by the robot; and S8, obtaining stable milling process parameters according to the lobe diagram of flutter stability.

Abstract: A device for repairing a top cover of a hydro turbine by adding or removing materials includes a rotating support base, a connecting arm, a movable frame, and a machining assembly. The rotating support base includes a base and a rotating seat disposed on the base, a driving assembly is disposed on the base, and an output shaft of the driving assembly is drivably connected to the rotating seat. An end of the connecting arm is connected to the rotating seat, and the other end of the connecting arm is connected to the movable frame. A lifting plate is disposed on the movable frame, a sliding table assembly and a measuring system are disposed on an upper side of the lifting plate. A swivel seat is disposed on an upper side of the sliding table assembly, and the machining assembly is detachably mounted on the swivel seat.

Abstract: Since defect areas in collected hydro turbine defect images account for a small proportion and there is a significant color difference between surrounding background and defects, which creates too much redundant information and greatly affects detection speed, a method for detecting defects in a hydro turbine top cover based on an improved YOLOv8 model involves first cropping collected defect images to obtain cropped images, then expanding the cropped images by image enhancement techniques such as image flipping and image blurring to obtain a training dataset. A defect detection network based on YOLOv8-CBAM is constructed and trained to generate a defect detection model for detecting the defects in the hydro turbine top cover. The method achieves high precision in defect detection for the hydro turbine top cover.

Abstract: An in-situ robot programming method for a hydraulic turbine top cover based on binocular structured light vision is provided, which relates to the field of robot vision-guided intelligent processing technologies. The method performs hand-eye calibration on a binocular structured light camera and a robot to construct a coordinate conversion relationship thereof, collects an annular to-be-processed area of the hydraulic turbine top cover by the binocular structured light camera for joining, and obtains a trajectory and a trajectory plan through point cloud processing algorithms, to thereby achieve a rapid programming for the hydraulic turbine top cover based on guidance of binocular structured light vision. The method adapts to changes in sizes of the hydraulic turbine top cover and take into account real-time performance and robustness, so that impacts of uncertainty factors on the system are greatly weakened, and the method has characteristics of intelligence and high degree of systematization.

Abstract: Provided is an aerosol generating device, comprising: a holder (31), wherein at least a portion of the tubular hollow of the holder forms a chamber (310) to receive a smokable material A; an induction coil (32) arranged on the holder; a susceptor (33) electromagnetically coupled with the induction coil to heat the smokable material A received in the chamber, wherein the susceptor comprises a heating portion (331) and a base portion (332); and a ceramic fixing seat (34) arranged in the holder, wherein the heating portion of the susceptor penetrates the ceramic fixing seat to reach the interior of the chamber, and the base portion abuts against the ceramic fixing seat to fix and maintain the susceptor.

Abstract: A processing system is configured to obtain data indicating answers of a user of one or more hearing instruments to a questionnaire. Additionally, the processing system is configured to determine an initial audiogram based on the answers. Furthermore, the processing system is configured to perform an initial fitting of the one or more hearing instruments based on the initial audiogram.

Abstract: An optical module including an upper shell part, a circuit board, a base, and a light reception component and a light emission component respectively disposed on upper and lower surfaces of the base; a base mounting portion is formed on the surface of the circuit board, through which the base is secured to the circuit board. In order to increase heat dissipation effect of the base, a protrusion is formed on an upper surface of the base, which protrudes towards and is in thermal connection with the upper shell part, conducting heat through the base. To dissipate heat generated by the light emission component more effectively, the light emission component is disposed on a lower surface of the base. Heat dissipation effect of the base is improved by forming the protrusion on the upper surface of the base and using it as a heat dissipation protrusion.

Abstract: The embodiment of this application provides a method and apparatus for positioning an entity controller, device and a storage medium. The method includes following steps: determining a relative pose relationship between an entity controller and an associated part of the entity controller, the relative pose relationship being determined from at least one entity controller pose and at least one associated part pose, the entity controller pose being determined from a first type of image, the associated part pose is determined from a second type of image, and the first type of image and the second type of image using different exposure policies; determining a current associated part pose, the current associated part pose being determined based on a current second type of image that is closest to the current; and determining an estimate pose of the entity controller based on the relative pose relationship and the current associated part pose.

Abstract: The disclosure relates to the wireless transmission field, and discloses a data transmission method and apparatus. An example method includes: A transmit end generates a data packet; and the transmit end sends the data packet to a receive end, where the data packet includes at least two pieces of video service data having different priorities, and the pieces of video service data having different priorities are carried on different communications resources for transmission.

Abstract: The present disclosure provides a preparation method of a yak hide-derived oligopeptide ferrous chelate with a high antioxidant activity. The preparation method includes preparing a yak hide-derived oligomeric collagen peptide and subjecting the yak hide-derived oligomeric collagen peptide as a protein source to chelation with an iron source in water. A pretreated yak hide is subjected to enzymatic hydrolysis under a pH value of 7 at 50° C. for 4 h with an amount of an enzyme added at 2% to obtain a yak skin-derived collagen with a molecular weight of less than 2 kDa; the chelation is conducted in a peptide-to-iron mass ratio of 1:1 to 5:1 with a peptide concentration of 1% to 5% at 30° C. to 70° C. for 20 min to 60 min under a pH value of 3 to 8; and an iron chelating capacity is 42.72 mg/g under optimal preparation conditions.

Abstract: Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds, or a pharmaceutically acceptable salt, stereoisomer, or tautomer thereof, have the following structure: wherein A, L1, L2, Q, R1, R2a, R3a, R3b, R4a, R4b, R9, R10, Y, and Z are as exemplified herein. Pharmaceutical compositions comprising such compounds, methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, and methods associated with preparation of such compounds are also provided.

Abstract: An electrical receptacle connector includes an insulated housing, a plurality of terminals, and a metallic plate. The terminals and the metallic plate are at the insulated housing. The terminals are held at the insulated housing and arranged into two rows. The metallic plate is at a tongue portion of the insulated housing and between the terminals which are arranged into two rows. The metallic plate has a main body and a plurality of extension portions. Each of the extension portions extends outwardly from the main body and corresponds to a protrusion of a corresponding one of the terminals. A distance between each of the protrusions and a corresponding one of the extension portions is less than a distance between each of the contact portions and the corresponding one of the extension portions. A retaining spacing is between the protrusions of the terminals and the extension portions of the metallic plate.

Abstract: A radio physical layer protocol data unit (PPDU) sending method includes: obtaining, a radio physical layer protocol data unit (PPDU), wherein the PPDU includes a high efficiency-signal field A (HE-SIG-A) and a high efficiency-signal field B (HE-SIG-B), the HE-SIG-A includes a field indicating a quantity of orthogonal frequency division multiplexing (OFDM) symbols in the HE-SIG-B, and wherein a value of the field indicates one of the following: that the quantity of OFDM symbols included in the HE-SIG-B is greater than or equal to 16, or the quantity of OFDM symbols included in the HE-SIG-B; and sending the PPDU.

Abstract: A method and apparatus for recognizing a three-dimensional gesture based on mark points, a device and a storage medium are provided. An image collected by each camera is acquired; for each image, an identifier and a corresponding two-dimensional coordinate position of each mark point in the image are determined; a three-dimensional coordinate position of each mark point in a coordinate system of a corresponding camera is determined according to the two-dimensional coordinate position of each mark point and a calibration parameter of the corresponding camera; the three-dimensional coordinate position is converted to an initial three-dimensional coordinate position in a coordinate system of the designated space; and a target three-dimensional coordinate position of each mark point in the coordinate system of the designated space is determined according to the initial three-dimensional coordinate position of each mark point in each image and the identifier of the corresponding mark point.

Abstract: The disclosure provides a method, an apparatus, an electronic device, and a storage medium for determining an exposure parameter. The method includes: acquiring a gesture detection image, and determining an image scene irradiance and a gesture detection result according to the gesture detection image, the gesture detection result including a gesture detection point and/or a gesture detection box; determining image brightness control information according to the image scene irradiance and the gesture detection result; and determining an image exposure parameter according to the image brightness control information. The method in the present disclosure can avoid the problem that gesture exposure oscillates due to instability of the gesture detection algorithm and the gesture region image having different brightness, and can provide an image having a stable brightness and high quality for the gesture detection algorithm.

Abstract: A method for preparing droplets using a microfluidic chip system is provided. The microfluidic chip system includes a droplet generation device, a power generation device, a collection bottle, a connection device, and a preparation platform, the droplet generation device includes a chip body, the chip body defines a continuous phase inlet for receiving a continuous phase and a dispersed phase inlet for receiving a dispersed phase. The power generation device is activated to form a pressure difference among the collection bottle, the connection device, and the chip body, wherein the pressure difference promotes the dispersed phase and the continuous phase to converge and flow into the collection bottle in form of the droplets.

Abstract: Methods, devices, apparatuses and systems are disclosed for performing mammography, such as utilizing tomosynthesis in combination with breast biopsy.

Abstract: An optical module includes a shell, a circuit board, a base, a laser assembly and a silicon optical chip. The laser assembly and the silicon optical chip are located on the base. The laser assembly includes an upper box, conductive substrates, laser chips and a light transmitting member. The upper box and the base are combined to provide a cavity. The cavity has an opening and a slot. The laser chips are located on the conductive substrates which are at least partially located in the cavity. The light transmitting member is disposed between the upper box and the base, and is configured to enclose the opening. Light exit surfaces of the laser chips are parallel to a light incident surface of the light transmitting member, and the light incident surface and a light exit surface of the light transmitting member are not parallel.