Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

Abstract: The invention relates to nucleic acid molecules for pseudouridylation of a target uridine in a target RNA in a mammalian cell, wherein the nucleic acid molecule comprises a guide region capable of forming a partially double stranded nucleic acid complex with the target RNA comprising the target uridine, wherein the partially double stranded nucleic acid complex is capable of engaging a mammalian pseudouridylation enzyme, wherein the guide region assists in positioning the target uridine in the partially double stranded nucleic acid complex for it to be converted to a pseudouridine by the mammalian pseudouridylation enzyme.

Abstract: A method of analyzing flowback of a downhole system includes generating active flowback data by monitoring an active flowback from a wellbore. Historic flowback data for historic flowback from the wellbore is used to determine a flowback cluster. The flowback cluster is selected based on comparing the active flowback data to the historic flowback data and determining one or more data instances of the historic flowback data that have features that are similar to that of the active flowback data. Based on the flowback cluster, one or more thresholds may be determined in order to generate an alert when the active flowback data exceeds the thresholds.

Abstract: A locking assembly includes a first structural member and a second structural member. The first structural member includes a first locking portion, and the second structural member includes a second locking portion. The second locking portion is separably locked with the first locking portion, to lock the first structural member with the second structural member and separate the first structural member from the second structural member.

Abstract: Embodiments of the present disclosure relate to a device, method, apparatus and computer readable storage medium for channel estimation in a multiple input multiple output (MIMO) system. The MIMO system comprises a receiver configured with a plurality of receiving antennas and a transmitter configured with a plurality of transmitting antennas. In example embodiments, a plurality of data symbols are detected based on channel estimation from a plurality of signals received by the plurality of receiving antenna from the plurality of transmitting antennas. The plurality of detected data symbols are adjusted based on a set of constellation points for a modulation mode used by the transmitter and associated with the plurality of signals. The channel estimation is updated based on the plurality of adjusted data symbols.

Abstract: A method includes forming a circuit region over a substrate. The circuit region includes at least one active region extending along a first direction, and at least one gate region extending across the at least one active region and along a second direction transverse to the first direction. At least one first input/output (TO) pattern and at least one second TO pattern are correspondingly formed in different first and second metal layers to electrically couple the circuit region to external circuitry outside the circuit region. The at least one first TO pattern extends along a third direction oblique to both the first direction and the second direction. The at least one second TO pattern extends along a fourth direction oblique to both the first direction and the second direction, the fourth direction transverse to the third direction.

Abstract: A housing assembly includes: a housing main body, including a partition slot; an antenna partition piece, connected to the housing main body and including a first partition portion filling the partition slot; and a reinforcing piece, connected to the antenna partition piece, where an angle is formed between an extension direction of the reinforcing piece and an extension direction of the partition slot, and a projection of the partition slot in a direction perpendicular to the extension direction of the reinforcing piece is at least partially located on the reinforcing piece.

Abstract: A method for performing a software update that reduces down time in a Radio Access Network (RAN) is disclosed. A first computing device receives first Distributed Unit (DU) configuration information including an address of a first radio unit (RU) device. The first computing device cause the first RU device to stores an address of the first computing device as a value of a configuration parameter. After a second computing device installs software, the second computing device receives the first DU configuration information including the address of the first RU device. The first computing device receives an instruction to stop data transmission to the first RU device. The second computing device causes the first RU device stores an address of the second computing device as the value of the configuration parameter. The second computing device receives an instruction to start data transmission to the first RU device.

Abstract: Systems, devices, and methods related to envelope regulated, digital predistortion (DPD) are provided. An example apparatus includes an envelope regulator circuit to process, based on a parameterized model, an input signal to generate an envelope regulated signal; a digital predistortion (DPD) actuator circuit to process the envelope regulated signal and the input signal based on DPD coefficients associated with a nonlinearity characteristic of a nonlinear component; and a DPD adaptation circuit to update the DPD coefficients based on a feedback signal indicative of an output of the nonlinear component.

Abstract: Provided are crystal forms A, B, C and D of a compound of formula (I), and application of the crystal forms in the preparation of drugs for treating ASK1-related diseases.

Abstract: Described herein are techniques for improving the signal-to-noise ratio of a wireless sensor platform. The device that interrogates a wireless sensor node (an interrogator) may be configured to determine the quantity to be measured by extracting information from multiple echoes produced in response to multiple interrogation pulses or produced due to multi-path propagation. Although different echoes may have been transformed to different extents, the echoes may share unique characteristics that are specific to the wireless sensor node that produced them. Accordingly, the SNR may be improved by keeping only portions of the received signal that exhibit such characteristics. The SNR may be further improved by summing the echoes together. In some embodiments, the echoes may be summed together in a coherent fashion, thereby producing an echo having an amplitude greater than the amplitude of each of the received echoes.

Abstract: The present disclosure provides a memory structure and a method for forming the same. The memory structure includes: a substrate; a plurality of discrete composite structures disposed on the substrate, wherein a first opening is formed between adjacent composite structures, and each composite structure includes a first conductive structure, a floating gate structure disposed on both sides of the first conductive structure, an erasing gate structure disposed on the floating gate structure, a first isolation structure, a second isolation structure and a third isolation structure disposed on the erasing gate structure; a plurality of mutually independent source doped regions disposed in the substrate, wherein the plurality of source doped regions are in contact with bottom surfaces of the first conductive structure and the floating gate structure; and a word line structure disposed in the first opening. Therefore, the performance and integration of the memory structure can be improved.

Abstract: The present application relates to a folded packaging container structure, and a bottom folding-sealing device and process, including: a folded packaging body, which forms a cavity for accommodating a object after being folded; an upper opening, which is located on the folded packaging body, at which a cap is provided at least after the cavity is loaded with the object; a folded part A and a folded part B, which are folded and contacted with each other; a front surface of the folded part A and a front surface of the folded part B are provided as corresponding front surfaces of the folded packaging body and are located between the bottom part and the upper opening; at least a first side surface and a second side surface located between the bottom part and the upper opening are provided between the front surfaces.

Abstract: A fungal cell capable of producing high levels of fatty acids and fatty acid-derived products comprises at least one modification to the endogenous fatty acid metabolism.

Abstract: An electronic device includes an accommodating chamber configured to accommodate a camera module, one side, opposite to a photosensitive component of the camera module, of the accommodating chamber is provided with a light-permeable piece, the accommodating chamber is provided with a first opening communicating an internal with an external of the accommodating chamber, the first opening is provided with an opening/closing piece, and the opening/closing piece has a first position and a second position, the opening/closing piece is configured to close the first opening to seal the accommodating chamber at the first position and to open the first opening to discharge moist airflow at the second position.

Abstract: A method for performing a software update that reduces down time in a Radio Access Network (RAN) is disclosed. A first computing device receives first Distributed Unit (DU) configuration information including an address of a first radio unit (RU) device. The first computing device cause the first RU device to stores an address of the first computing device as a value of a configuration parameter. After a second computing device installs software, the second computing device receives the first DU configuration information including the address of the first RU device. The first computing device receives an instruction to stop data transmission to the first RU device. The second computing device causes the first RU device stores an address of the second computing device as the value of the configuration parameter. The second computing device receives an instruction to start data transmission to the first RU device.

Abstract: Disclosed is a method of operating a Radio Access Network (RAN) including a Radio Unit (RU), a first Distributed Unit (DU), a second DU that functions as a dynamic standby DU, and a network management device. After the RU transmits data to the first DU using a configuration parameter set to an address of the first DU, the RU detects an outage of the first DU. In response to detecting the outage, the RU transmits to the network management device a message indicating detection of the outage. In response, the network management device configures the second DU to perform the functions of the first DU, and causes the second DU to request the RU to set the configuration parameter to an address of the second DU. The RU then uses the configuration parameter set to the address of the second DU to transmit data to the second DU.

Abstract: Remote keyless entry (RKE) systems and devices are described. The RKE devices include one or more passive radios that respond to an interrogation signal from an interrogating device such as a vehicle. The passive radio sends a responsive signal that can include a decaying portion representing a ringdown signal. The passive radio includes a SAW resonator in some situations.

Abstract: A method of making a glass mat includes providing an assembly of glass fibers, applying a binder composition to the assembly of glass fibers, wherein the binder includes an organic resin, and curing the binder composition while dimensionally constraining the assembly of glass fibers. Dimensional constraining includes directly contacting a first major surface and a second major surface of the assembly of glass fibers between two substantially parallel surfaces. Further provided is a glass mat that includes an assembly of glass fibers, wherein the assembly of glass fibers are substantially randomly oriented with a tensile anisotropy of less than about 6 in any two directions. The glass mat has a decreased surface roughness and a decreased caliper compared to an equivalent glass mat having an assembly of naturally packed glass fibers with an equivalent fiber diameter size.

Abstract: Systems and methods for improving design performance of a layout design through placement of functional and spare cells by leveraging layout dependent effect(LDE) is disclosed. The method includes the steps of: importing a plurality of technology files associated with the layout design into an EDA system; importing a netlist associated with the layout design into the EDA system; importing a standard cell library containing pattern-S timing information of the functional cells and the spare cells; performing floorplan and spare cell insertion, wherein the spare cells are distributed uniformly across the floorplan; and conducting placement and optimization through re-placement of the at least one functional cells and the spare cells to form pattern-S with at least one timing critical cells to improve an overall timing performance of the layout design.