Abstract: A tunable mass damping device, including a connecting, a weighted assembly, and a top connecting assembly connecting an upper end of the connecting rod with a tower beam of a tower and including an anti-rotation mechanism. The anti-rotation mechanism includes: a laterally extending fixing plate fixedly connected with the tower beam through a longitudinally extending supporting member; a laterally extending first movable plate arranged under the fixing plate and fixedly connected with the upper end of the connecting rod; and two connecting shafts spaced apart from each other. Each of the connecting shafts has a lower end fixedly connected to the first movable plate, and an upper end inserted into the fixing plate and connected therewith through a connecting head. The connecting head includes an intermediate elastic layer arranged between inner and outer sleeves of the connecting head.

Abstract: A photoelectric computing unit, a photoelectric computing array and a photoelectric computing method. The photoelectric computing unit includes a semiconductor multifunctional region structure, which includes at least one carrier control region, at least one coupling region, and at least one photon-generated carrier collection region and readout region.

Abstract: A system and method for determining a critical suspension speed of an impeller in a solid-liquid stirred tank belongs to the technical field of critical speed determination. A relationship is established between a voltage of a measurement electrode and a solid-liquid suspension state to avoid the problems of strong subjectivity and large deviation appearing in existing critical suspension speed determination based on empirical formulas and human eye observation. An electrode voltage ratio is taken as a determination criterion, which is only related to a spatial density of solid particles in a liquid phase.

Abstract: Provided are an imaging method and apparatus, and a medium. The method includes: for a target field of view, performing photographing and quantification at a first resolution, to obtain a first image that has a first bit width; for the target field of view, performing photographing and differential processing at a second resolution, to obtain a second image that has a second bit width, wherein the differential processing includes: for a pixel point obtained by photographing at the second resolution, quantifying the difference between the pixel point and a neighboring pixel point of the pixel point, to obtain a quantified difference a value of a corresponding pixel point in the second image; and fusing the first image with the second image, to obtain a third image, wherein the first resolution is lower than the second resolution, and the first bit width is higher than the second bit width.

Abstract: The present disclosure provides a magnetic dressing and a preparation method and use thereof, belonging to the technical field of pharmaceutical preparations. The magnetic dressing includes a magnetic layer, a drug-loading layer, and a protective layer that are stacked in sequence, where the magnetic layer includes polyvinyl alcohol, gluten, and iron particles. In the present disclosure, a swallowed magnetic dressing is controlled by an external magnetic field, and the magnetic dressing is moved to a pathological position by changing a direction of the external magnetic field; after the external magnetic field is removed, the magnetic dressing changes from a ring to a sheet, thereby completing attachment of an entire lesion surface to complete treatment by autonomous drug release.

Abstract: The present invention includes compositions, methods, nucleic acids, vectors and host cells, that include an IL-2 receptor binding fusion protein comprising: an IL-2 mutant protein that binds the IL-2 receptor; and an antibody Fc fragment; wherein IL-2 mutant protein binds and maintains its activity through the IL-2 receptor at a low pH.

Abstract: The present disclosure provides a magnetic dressing and a preparation method and use thereof, belonging to the technical field of pharmaceutical preparations. The magnetic dressing includes a magnetic layer, a drug-loading layer, and a protective layer that are stacked in sequence, where the magnetic layer includes polyvinyl alcohol, gluten, and iron particles. In the present disclosure, a swallowed magnetic dressing is controlled by an external magnetic field, and the magnetic dressing is moved to a pathological position by changing a direction of the external magnetic field; after the external magnetic field is removed, the magnetic dressing changes from a ring to a sheet, thereby completing attachment of an entire lesion surface to complete treatment by autonomous drug release.

Abstract: The present invention includes proteins, nucleic acids and methods of making and using an activatable interleukin-2 (aIL2) comprising an Interleukin-2 (aIL2) fusion protein comprising: an Interleukin-2 (IL2) wild-type or mutein; a first cleavable linker; an interleukin-2 receptor binding region (IL2RB), and a half-life extender, such as an antibody Fc region, wherein cleavage of the cleavable linker releases the IL2 from the interleukin-2 receptor beta binding region.

Abstract: The present invention includes compositions and methods for making and using the next generation of activatable pro-cytokine drugs by using a single-chain fragment crystallizable (Fc) region. This single-chain Fc fusion protein is engineered according to the formulas: P1-L-Fc-L-P2-L-Fc, or P1-L-Fc-L-P2-L-Fc-L-P3 in a linear sequence from amino- to carboxy-terminus, wherein protein (P) is the biologically active moiety, e.g., an antibody, or an antigen-binding fragment, or a cytokine receptor, or a cytokine, or a fusion protein consisting of above-mentioned components; L is optional and a protease cleavable, or non-cleavable linker (up to 50-mers amino acids) that is processed by enzymes enriched in tumor tissues, wherein P1, P2, and P3 are different biologically active moieties, but at least one of them is a cytokine that forms an intramolecular heterodimer. Processing the cleavable linker by tumor-specific enzymes serves as a switch to activate the cytokine in the tumor microenvironment.

Abstract: A multi-layered microfluidic system featuring tissue chambers for cells in a first layer and a plurality of medium channels for culture medium in a second layer. The tissue chambers fluidly connect to the medium channels such that media flows from the medium channels to the tissue chambers, forming large-scale perfused capillary networks. The capillary networks can undergo angiogenesis and vertical anastomosis. The multi-layered configuration of the system of the present invention allows for flexibility in design.

Abstract: A tunable mass damping device, including a connecting, a weighted assembly, and a top connecting assembly connecting an upper end of the connecting rod with a tower beam of a tower and including an anti-rotation mechanism. The anti-rotation mechanism includes: a laterally extending fixing plate fixedly connected with the tower beam through a longitudinally extending supporting member; a laterally extending first movable plate arranged under the fixing plate and fixedly connected with the upper end of the connecting rod; and two connecting shafts spaced apart from each other. Each of the connecting shafts has a lower end fixedly connected to the first movable plate, and an upper end inserted into the fixing plate and connected therewith through a connecting head. The connecting head includes an intermediate elastic layer arranged between inner and outer sleeves of the connecting head.

Abstract: A photoelectric computing unit, a photoelectric computing array and a photoelectric computing method. The photoelectric computing unit includes a semiconductor multifunctional region structure, which includes at least one carrier control region, at least one coupling region, and at least one photon-generated carrier collection region and readout region.

Abstract: The present invention includes proteins, nucleic acids and methods of making and using an activatable interleukin-2 (aIL2) comprising an Interleukin-2 (aIL2) fusion protein comprising: an Interleukin-2 (IL2) wild-type or mutein; a first cleavable linker; an interleukin-2 receptor binding region (IL2RB), and a half-life extender, such as an antibody Fc region, wherein cleavage of the cleavable linker releases the IL2 from the interleukin-2 receptor beta binding region.

Abstract: The present invention discloses a method for interpreting and evaluating production profile of multi-layer gas reservoir based on downhole distributed temperature monitoring, including: obtaining downhole distributed temperature monitoring data of target well; preprocessing the downhole distributed temperature monitoring data; segmenting the temperature monitoring data according to test curve characteristics of the target well and logging interpretation results; using a multi-layer gas reservoir seepage pressure field—temperature field coupled model to calculate temperatures of each layer in the borehole production profile of the target well by numerical simulation method; comparing the temperatures of each layer of the borehole production profile with the temperature monitoring data after segmentation, obtaining the optimal flow rate of each production layer with optimization theories, and obtaining the production profile of the target well based on the optimal flow rate of each production layer.

Abstract: The spring includes an elastic member having a liquid accommodating chamber. The sealing member includes a base plate, a pressure plate, and a pressure elastic membrane provided in the liquid accommodating chamber. The pressure elastic membrane has a lip portion radially extending from an end portion of the pressure elastic membrane. The lip portion is provided with a projection. The pressure plate and the base plate define a clamping recess together. The lip portion is pressed in the clamping recess to seal the liquid accommodating chamber.

Abstract: Disclosed is a vibration-damping support device, including a housing, and a core shaft having one end passing through the housing to connect with a vibration source. The vibration-damping support device further includes two elastic members arranged within the housing and spaced apart from each other. Each elastic member includes an inner hole, so that it can be mounted on the core shaft. Each elastic member includes an elastic rubber body, and a plurality of metal plates that are embedded in the elastic rubber body and parallel to each other. The elastic rubber body extends beyond the metal plates in a radial direction. With this vibration-damping support device, a variable stiffness can be achieved.

Abstract: A learned image compression system increases compression efficiency by using a novel conditional context model with embedded autoregressive neighbors and hyperpriors, which can accurately estimate the entropy rate for rate distortion optimization. Generalized Divisive Normalization (GDN) in Residual Neural Network is used in the encoder and decoder networks for fast convergence rate and efficient feature representation.

Abstract: A method for synthesizing a ketoxime is provided. In a system of an aqueous carbonate solution, a reaction is performed on a ketone, ammonia and hydrogen peroxide by using a titanium-silicon molecular sieve as a catalyst to obtain the ketoxime. Moreover, a reaction progress is judged and an optimal reaction ratio is determined by a real-time monitoring of a pH value in a reaction system during the reaction. In the present invention, by monitoring the pH value in the reaction system, the progress of the reaction is judged, thereby determining the optimal reaction ratio. The pH of the system is further adjusted by an aqueous carbonate solution to increase the reaction velocity and conversion rate of the ammonia.

Abstract: A method for synthesizing a ketoxime is provided. In a system of an aqueous carbonate solution, a reaction is performed on a ketone, ammonia and hydrogen peroxide by using a titanium-silicon molecular sieve as a catalyst to obtain the ketoxime. Moreover, a reaction progress is judged and an optimal reaction ratio is determined by a real-time monitoring of a pH value in a reaction system during the reaction. In the present invention, by monitoring the pH value in the reaction system, the progress of the reaction is judged, thereby determining the optimal reaction ratio. The pH of the system is further adjusted by an aqueous carbonate solution to increase the reaction velocity and conversion rate of the ammonia.

Abstract: A multi-layered microfluidic system featuring tissue chambers for cells in a first layer and a plurality of medium channels for culture medium in a second layer. The tissue chambers fluidly connect to the medium channels such that media flows from the medium channels to the tissue chambers, forming large-scale perfused capillary networks. The capillary networks can undergo angiogenesis and vertical anastomosis. The multi-layered configuration of the system of the present invention allows for flexibility in design.