Patents by Inventor Tao Zu

Tao Zu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250041247
    Abstract: The present disclosure provides methods, uses, kits, and compositions comprising a compound of Formula (I), and either a second compound of Formula (I) or a compound of Formula (II). In one aspect, the methods are for treating a neurological disease associated with repeat expansions and/or RAN protein accumulation, reducing the level of one or more repeat associated non-AUG (RAN) proteins, and reducing the accumulation of RAN proteins in a subject and/or biological sample. Exemplary diseases associated with repeat expansions include, but are not limited to, amyotrophic lateral sclerosis (ALS), frontotemporal dementia, myotonic dystrophy type 1, myotonic dystrophy type 2, spinocerebellar ataxia, Alzheimer's disease, Huntington's disease, Fragile X Tremor Ataxia Syndrome, and Fragile XE syndrome.
    Type: Application
    Filed: December 1, 2022
    Publication date: February 6, 2025
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Laura Ranum, Tao Zu
  • Publication number: 20240393348
    Abstract: Disclosed herein are methods and compositions for identifying and/or treating subjects having or likely to have amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD). Antibodies specific for one or more di-amino acid repeat-containing proteins are also provided herein.
    Type: Application
    Filed: May 20, 2024
    Publication date: November 28, 2024
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Laura Ranum, Tao Zu
  • Publication number: 20240269093
    Abstract: The present disclosure provides the use of compounds of Formulae (I), (II), (III), (III-A), and (III-B) (e.g., metformin) in treating a neurological disease associated with repeat expansions and/or RAN protein accumulation, reducing the level of one or more repeat associated non-ATG (RAN) proteins, and reducing the accumulation of RAN proteins in a subject and/or biological sample. Also provided is the use of compounds of Formulae (I), (II), (III), (III-A), and (III-B) (e.g., metformin) in inhibiting RAN protein translation in a subject and in a biological sample (e.g., cells, tissue). Also provided in the present disclosure are pharmaceutical compositions, kits, and uses of compounds of Formulae (I), (II), (III), (III-A), and (III-B) (e.g., metformin) for treating diseases associated with repeat expansions.
    Type: Application
    Filed: January 3, 2024
    Publication date: August 15, 2024
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Laura Ranum, Tao Zu
  • Patent number: 12025622
    Abstract: Disclosed herein are methods and compositions for identifying and/or treating subjects having or likely to have amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD). Antibodies specific for one or more di-amino acid repeat-containing proteins are also provided herein.
    Type: Grant
    Filed: May 17, 2021
    Date of Patent: July 2, 2024
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Laura Ranum, Tao Zu
  • Patent number: 11903910
    Abstract: The present disclosure provides the use of compounds of Formulae (I), (II), (III), (III-A), and (III-B) (e.g., metformin) in treating a neurological disease associated with repeat expansions and/or RAN protein accumulation, reducing the level of one or more repeat associated non-ATG (RAN) proteins, and reducing the accumulation of RAN proteins in a subject and/or biological sample. Also provided is the use of compounds of Formulae (I), (II), (III), (III-A), and (III-B) (e.g., metformin) in inhibiting RAN protein translation in a subject and in a biological sample (e.g., cells, tissue). Also provided in the present disclosure are pharmaceutical compositions, Skits, and uses of compounds of Formulae (I), (II), (III), (III-A), and (III-B) (e.g., metformin) for treating diseases associated with repeat expansions.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: February 20, 2024
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Laura Ranum, Tao Zu
  • Publication number: 20240036141
    Abstract: A joint k-space and image-space reconstruction imaging method and a device, relating to the field of magnetic resonance imaging. The method comprises: first, using the k-space parallel imaging method to reconstruct under-sampled image frames having auto-calibration signals of a subject obtained from multi-frame imaging required for the measurement of magnetic resonance parameters; and then performing reconstruction in image space for other under-sampled image frame data without auto-calibration signals. In the method, an accurate sensitivity map required for the SENSE method is generated from under-sampled data, without the need of additional acquisition. By means of the present method, images that are almost identical to those obtained by the traditional GRAPPA method and without obvious artifacts can be obtained at a speed which is four times faster than that by the traditional GRAPPA method.
    Type: Application
    Filed: October 8, 2023
    Publication date: February 1, 2024
    Inventors: Yi ZHANG, Tao ZU, Dan WU
  • Publication number: 20230002753
    Abstract: Methods and compositions for modulating repeat non-ATG protein (RAN protein) translation are provided. In some aspects, the disclosure provides methods of inhibiting RAN protein translation by contacting a cell with an effective amount of an inhibitor of eIF2 phosphorylation or an inhibitor of protein kinase R (PKR). In some embodiments, methods described by the disclosure are useful for treating diseases associated with RAN protein translation, such as certain neurodegenerative diseases.
    Type: Application
    Filed: May 27, 2022
    Publication date: January 5, 2023
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Laura Ranum, Tao Zu
  • Patent number: 11345911
    Abstract: Methods and compositions for modulating repeat non-ATG protein (RAN protein) translation are provided. In some aspects, the disclosure provides methods of inhibiting RAN protein translation by contacting a cell with an effective amount of an inhibitor of eIF2 phosphorylation or an inhibitor of protein kinase R (PKR). In some embodiments, methods described by the disclosure are useful for treating diseases associated with RAN protein translation, such as certain neurodegenerative diseases.
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: May 31, 2022
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Laura Ranum, Tao Zu
  • Publication number: 20210285970
    Abstract: Disclosed herein are methods and compositions for identifying and/or treating subjects having or likely to have amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD). Antibodies specific for one or more di-amino acid repeat-containing proteins are also provided herein.
    Type: Application
    Filed: May 17, 2021
    Publication date: September 16, 2021
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Laura Ranum, Tao Zu
  • Publication number: 20210236535
    Abstract: Methods and compositions for modulating repeat non-ATG protein (RAN protein) translation are provided. In some aspects, the disclosure relates to methods for treating a subject having a disease associated with RAN protein translation by administering the subject a modulator of eIF3 or an eIF3 subunit, or an antibody that bind to a RAN protein.
    Type: Application
    Filed: January 27, 2021
    Publication date: August 5, 2021
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Laura Ranum, Fatma Ayhan, Tao Zu
  • Patent number: 11035867
    Abstract: Disclosed herein are methods and compositions for identifying and/or treating subjects having or likely to have amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD). Antibodies specific for one or more di-amino acid repeat-containing proteins are also provided herein.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: June 15, 2021
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Laura Ranum, Tao Zu
  • Patent number: 10940161
    Abstract: Methods and compositions for modulating repeat non-ATG protein (RAN protein) translation are provided. In some aspects, the disclosure relates to methods for treating a subject having a disease associated with RAN protein translation by administering the subject a modulator of eIF3 or an eIF3 subunit, or an antibody that bind to a RAN protein.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: March 9, 2021
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Laura Ranum, Fatma Ayhan, Tao Zu
  • Publication number: 20200341012
    Abstract: Disclosed herein are methods and compositions for identifying and/or treating subjects having or likely to have amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD). Antibodies specific for one or more di-amino acid repeat-containing proteins are also provided herein.
    Type: Application
    Filed: April 17, 2020
    Publication date: October 29, 2020
    Applicant: University of Florida Research Foundation,Incorporated
    Inventors: Laura Ranum, Tao Zu
  • Publication number: 20200268691
    Abstract: The present disclosure provides the use of compounds of Formulae (I), (II), (III), (III-A), and (III-B) (e.g., metformin) in treating a neurological disease associated with repeat expansions and/or RAN protein accumulation, reducing the level of one or more repeat associated non-ATG (RAN) proteins, and reducing the accumulation of RAN proteins in a subject and/or biological sample. Also provided is the use of compounds of Formulae (I), (II), (III), (III-A), and (III-B) (e.g., metformin) in inhibiting RAN protein translation in a subject and in a biological sample (e.g., cells, tissue). Also provided in the present disclosure are pharmaceutical compositions, Skits, and uses of compounds of Formulae (I), (II), (III), (III-A), and (III-B) (e.g., metformin) for treating diseases associated with repeat expansions.
    Type: Application
    Filed: September 26, 2018
    Publication date: August 27, 2020
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Laura Ranum, Tao Zu
  • Publication number: 20200206255
    Abstract: Methods and compositions for modulating repeat non-ATG protein (RAN protein) translation are provided. In some aspects, the disclosure relates to methods for treating a subject having a disease associated with RAN protein translation by administering the subject a modulator of eIF3 or an eIF3 subunit, or an antibody that bind to a RAN protein.
    Type: Application
    Filed: April 4, 2017
    Publication date: July 2, 2020
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Laura Ranum, Fatma Ayhan, Tao Zu
  • Patent number: 10663475
    Abstract: Disclosed herein are methods and compositions for identifying and/or treating subjects having or likely to have amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD). Antibodies specific for one or more di-amino acid repeat-containing proteins are also provided herein.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: May 26, 2020
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Laura Ranum, Tao Zu
  • Publication number: 20200140846
    Abstract: Methods and compositions for modulating repeat non-ATG protein (RAN protein) translation are provided. In some aspects, the disclosure provides methods of inhibiting RAN protein translation by contacting a cell with an effective amount of an inhibitor of eIF2 phosphorylation or an inhibitor of protein kinase R (PKR). In some embodiments, methods described by the disclosure are useful for treating diseases associated with RAN protein translation, such as certain neurodegenerative diseases.
    Type: Application
    Filed: April 17, 2018
    Publication date: May 7, 2020
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Laura Ranum, Tao Zu
  • Publication number: 20190285652
    Abstract: Disclosed herein are methods and compositions for identifying and/or treating subjects having or likely to have amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD). Antibodies specific for one or more di-amino acid repeat-containing proteins are also provided herein.
    Type: Application
    Filed: March 25, 2019
    Publication date: September 19, 2019
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Laura Ranum, Tao Zu
  • Patent number: 10295547
    Abstract: Disclosed herein are methods and compositions for identifying and/or treating subjects having or likely to have amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD). Antibodies specific for one or more di-amino acid repeat-containing proteins are also provided herein.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: May 21, 2019
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Laura Ranum, Tao Zu
  • Publication number: 20190142858
    Abstract: Methods and compositions for modulating repeat non-ATG protein (RAN protein) translation are provided. In some aspects, the disclosure relates to methods for treating a subject having a disease associated with RAN protein translation by administering the subject a modulator of eIF3 or an eIF3 subunit, or an antibody that bind to a RAN protein.
    Type: Application
    Filed: April 4, 2017
    Publication date: May 16, 2019
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Laura Ranum, Fatma Ayhan, Tao Zu