Patents by Inventor Taoling ZENG

Taoling ZENG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Five-membered-fused-six-membered aza-aromatic ring compound, preparation method thereof, pharmaceutical composition and application thereof
    Patent number: 11292787
    Abstract: The invention relates to the field of medicinal chemistry, and to five-membered-fused-six-membered aza-aromatic ring compound, preparation method thereof, pharmaceutical composition and application thereof. In particular, the invention relates to a type of compounds capable of specifically enhancing ubiquitination degradation of Ras proteins, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with Ras activity in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: April 5, 2022
    Assignee: Xiamen University
    Inventors: Xianming Deng, Hongrui Wang, Taoling Zeng, Ting Zhang, Tingting Jiang
  • METHOD FOR ADJUSTING RAS UBIQUITINATION
    Publication number: 20210228552
    Abstract: Provided is use of E3 ubiquitin ligase Nedd4-1 in preparation of a drug for inhibiting the Ras protein level. Also provided is use in preparation of a drug for preventing and/or treating tumors or a drug for prolonging the life span of organisms.
    Type: Application
    Filed: April 25, 2019
    Publication date: July 29, 2021
    Applicant: Xiamen University
    Inventors: Hongrui WANG, Xianming DENG, Taoling ZENG, Tingting JIANG