Patents by Inventor Taotao Liu
Taotao Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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APPLICATION OF GOSSYPOL AND ITS OPTICAL ISOMERS TO PREPARATION OF CORONAVIRUS 3CL PROTEASE INHIBITOR
Publication number: 20240074990Abstract: The present invention relates to application of gossypol and its optical isomers to preparation of an anti-Coronavirus drug. Specifically disclosed is application of pharmaceutically acceptable salts, solvates, isotopes, stereoisomers, stereoisomer mixtures, and tautomers of the gossypol and its optical isomers to preparation of a drug for preventing and/or treating a disease caused by a Coronavirus. The Coronavirus is MERS-CoV, SARS-CoV, or SARS-CoV-2. It is found in the present invention for the first time that the gossypol and its optical isomers can inhibit the activity of Coronavirus 3CL proteases to achieve an anti-Coronavirus effect. The half maximal inhibitory concentrations of gossypol and (?)-gossypol to SARS-CoV proteases and SARS-CoV-2 3CL proteases are all lower than 10 ?M. The anti-Coronavirus 3CL protease effect is good. Therefore, the gossypol and its optical isomers have the potential for use in the preparation of a drug for preventing and/or treating novel Coronavirus infections.Type: ApplicationFiled: March 18, 2023Publication date: March 7, 2024Inventors: Xiaolin XIE, Dezhu ZHANG, Zhao MA, Boyang LI, Xuhua ZHOU, Lei TIAN, Chengyuan LIANG, Taotao QIANG, Jingyi LI, Liang XIN, Shaojun ZHANG, Kangxiong WU, Xiuding YANG, Sundian LIU, Yuting LIU -
Patent number: 11809300Abstract: This application provides a trace chain information query method, including: receiving, by a trace chain server, first trace chain information sent by a first service node and second trace chain information sent by a second service node, where the first service node is a service node in a first trace chain, the second service node is a service node in a second trace chain, both the first trace chain and the second trace chain are generated as triggered by a same user operation, the first trace chain information includes a group identifier, the second trace chain information includes the group identifier, and the group identifier is used to indicate the user operation; and finding, by the trace chain server, the first trace chain information and the second trace chain information based on the group identifier.Type: GrantFiled: August 26, 2021Date of Patent: November 7, 2023Assignee: HUAWEI CLOUD COMPUTING TECHNOLOGIES CO., LTD.Inventors: Xiaofeng Yang, Dongmei Xie, Zhong Sheng, Taotao Liu, Kaifang Ding, Cheng Li, Feng Ye
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Publication number: 20210399381Abstract: A cast piece cooling method, a gel sheet, a multilayer microporous polyethylene separator, and a preparation method are provided. The cast piece cooling method includes: changing an opening degree of a die head so that a molten material flowing out of the die head is an arc-shaped molten material; calendering a cast piece so that the arc-shaped molten material passes vertically through a gap between a first casting roller and a pinch roller to form a calendered cast piece; and gradually cooling, so that the calendered cast piece is guided and transported along surfaces of other casting rollers to the last casting roller, and cooling the calendered cast piece, to obtain a gel sheet.Type: ApplicationFiled: August 3, 2020Publication date: December 23, 2021Applicant: JIANGSU HORIZON NEW ENERGY TECH CO., LTD.Inventors: Tao JIANG, Xingxing WENG, Zhengli WANG, Aibin SUN, Taotao LIU
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Publication number: 20210390031Abstract: This application provides a trace chain information query method, including: receiving, by a trace chain server, first trace chain information sent by a first service node and second trace chain information sent by a second service node, where the first service node is a service node in a first trace chain, the second service node is a service node in a second trace chain, both the first trace chain and the second trace chain are generated as triggered by a same user operation, the first trace chain information includes a group identifier, the second trace chain information includes the group identifier, and the group identifier is used to indicate the user operation; and finding, by the trace chain server, the first trace chain information and the second trace chain information based on the group identifier.Type: ApplicationFiled: August 26, 2021Publication date: December 16, 2021Inventors: Xiaofeng YANG, Dongmei XIE, Zhong SHENG, Taotao LIU, Kaifang DING, Cheng LI, Feng YE
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Patent number: 11186694Abstract: A polyolefin porous separator includes a first surface and a second surface corresponding to the first surface. The surfaces of the polyolefin porous separator contain dendritic crystals and micropores, the dendritic crystals intersect with the micropores on the first surface or/and the second surface, and the dendritic crystals penetrate through the second surface from the first surface. A preparation method of the polyolefin porous separator includes: (1) a mixed melting of polyethylene resin and a mineral oil; (2) an extrusion of the mineral oil/polyethylene resin molten mixture; (3) a stretching of a thick sheet in a machine direction (MD); (4) a stretching of the separator in a transverse direction (TD); (5) immersing the separator into a solvent to extract the mineral oil; (6) a secondary stretching of the separator in the TD; and (7) subjecting the separator having the longitudinal crystals to a heat-setting treatment and then rolling up.Type: GrantFiled: May 21, 2020Date of Patent: November 30, 2021Assignee: JIANGSU HORIZON NEW ENERGY TECH CO., LTD.Inventors: Peiliang Jia, Xingxing Weng, Taotao Liu, Zhengli Wang, Aibin Sun
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Publication number: 20210253812Abstract: A polyolefin porous separator includes a first surface and a second surface corresponding to the first surface. The surfaces of the polyolefin porous separator contain dendritic crystals and micropores, the dendritic crystals intersect with the micropores on the first surface or/and the second surface, and the dendritic crystals penetrate through the second surface from the first surface. A preparation method of the polyolefin porous separator includes: (1) a mixed melting of polyethylene resin and a mineral oil; (2) an extrusion of the mineral oil/polyethylene resin molten mixture; (3) a stretching of a thick sheet in a machine direction (MD); (4) a stretching of the separator in a transverse direction (TD); (5) immersing the separator into a solvent to extract the mineral oil; (6) a secondary stretching of the separator in the TD; and (7) subjecting the separator having the longitudinal crystals to a heat-setting treatment and then rolling up.Type: ApplicationFiled: May 21, 2020Publication date: August 19, 2021Applicant: JIANGSU HORIZON NEW ENERGY TECH CO., LTD.Inventors: Peiliang JIA, Xingxing WENG, Taotao LIU, Zhengli WANG, Aibin SUN
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Patent number: 10435266Abstract: An automatic mesh reeling machine includes a manual fiber loading mesh disc mechanism, a quantitative fiber mesh conveying mechanism, a fiber mesh cutting mechanism, an automatic mesh reeling mechanism of left and right mesh reeling hands, an automatic fiber mesh drum delivery mechanism and an automatic mesh stapling mechanism of a mesh stapler. Information about replacing a mesh disc can be transmitted under the cooperation of a mesh pressing rod and a micro switch. A servo motor drives a metering roll to realize fixed length feeding of a mesh. A cutter cylinder drives a blade to cut the fixed length mesh. A left mesh reeling hand and a right mesh reeling hand reel the mesh into a closed mesh drum. A sliding table cylinder, pneumatic parallel clamping jaws and an electric servo cylinder move the fiber mesh drum to a specified position.Type: GrantFiled: June 12, 2017Date of Patent: October 8, 2019Assignee: QINHUANGDAO XINYUE INTELLIGENT EQUIPMENT CO., LTD.Inventors: Guoxin Xiao, Taotao Liu, Chong Li, Yan Sun
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Patent number: 10281899Abstract: The invention provides a mechanical bar conveying device consisting of a horizontal travel limiting device (1), a vertical axis servo reducer (2), a vertical descent depth detector (3), a vertical axis travelling mechanism (4), a horizontal axis servo reducer (5), a horizontal drive gear (6), a horizontal tow chain (7), a horizontal moving mechanism (8), a manipulator torque detector (9), a safety detection mechanism (10), a main frame (11), a horizontal frame (12), a vertical movement mechanism (16), a tow chain bracket (17), a tow chain (18), a vertical rack-and-pinion mechanism (19), a horizontal linear guide track (20), a vertical beam (21), a claw clamping mechanism (22), a claw ball screw (23), a manipulator servo reducer (24), a manipulator depth detector (25), and a claw and travel limiting combined mechanism (26).Type: GrantFiled: October 27, 2016Date of Patent: May 7, 2019Assignee: CITIC Dicastal CO., LTDInventor: Taotao Liu
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Publication number: 20180282095Abstract: An automatic mesh reeling machine includes a manual fiber loading mesh disc mechanism, a quantitative fiber mesh conveying mechanism, a fiber mesh cutting mechanism, an automatic mesh reeling mechanism of left and right mesh reeling hands, an automatic fiber mesh drum delivery mechanism and an automatic mesh stapling mechanism of a mesh stapler. Information about replacing a mesh disc can be transmitted under the cooperation of a mesh pressing rod and a micro switch. A servo motor drives a metering roll to realize fixed length feeding of a mesh. A cutter cylinder drives a blade to cut the fixed length mesh. A left mesh reeling hand and a right mesh reeling hand reel the mesh into a closed mesh drum. A sliding table cylinder, pneumatic parallel clamping jaws and an electric servo cylinder move the fiber mesh drum to a specified position.Type: ApplicationFiled: June 12, 2017Publication date: October 4, 2018Inventors: Guoxin Xiao, Taotao Liu, Chong Li, Yan Sun
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Publication number: 20170123405Abstract: The invention provides a mechanical bar conveying device consisting of a horizontal travel limiting device (1), a vertical axis servo reducer (2), a vertical descent depth detector (3), a vertical axis travelling mechanism (4), a horizontal axis servo reducer (5), a horizontal drive gear (6), a horizontal tow chain (7), a horizontal moving mechanism (8), a manipulator torque detector (9), a safety detection mechanism (10), a main frame (11), a horizontal frame (12), a vertical movement mechanism (16), a tow chain bracket (17), a tow chain (18), a vertical rack-and-pinion mechanism (19), a horizontal linear guide track (20), a vertical beam (21), a claw clamping mechanism (22), a claw ball screw (23), a manipulator servo reducer (24), a manipulator depth detector (25), and a claw and travel limiting combined mechanism (26).Type: ApplicationFiled: October 27, 2016Publication date: May 4, 2017Inventor: Taotao Liu