Abstract: The present disclosure provides a composition comprising a compound of formula (I) or a physiologically acceptable salt thereof, in which the compound of formula (I) or a physiologically acceptable salt thereof has a HPLC purity of ?90%; wherein R1, R2, X and n are as defined herein. The present disclosure further provides use of the composition according to the present disclosure for preparing and/or purifying a composition comprising a salt of the compound of formula (I), and a method for treating a disease caused by a Coronavirus which comprises administering the composition of the present disclosure to a subject. The composition of the present disclosure comprises the compound of formula (I) with high purity, and has good fluidity and anti-caking property; moreover, the claimed composition comprising the compound of formula (I)) with high purity is more suitable for preparing a composition comprising a salt of the compound of formula (I) with higher purity.

Abstract: The present invention relates to application of gossypol and its optical isomers to preparation of an anti-Coronavirus drug. Specifically disclosed is application of pharmaceutically acceptable salts, solvates, isotopes, stereoisomers, stereoisomer mixtures, and tautomers of the gossypol and its optical isomers to preparation of a drug for preventing and/or treating a disease caused by a Coronavirus. The Coronavirus is MERS-CoV, SARS-CoV, or SARS-CoV-2. It is found in the present invention for the first time that the gossypol and its optical isomers can inhibit the activity of Coronavirus 3CL proteases to achieve an anti-Coronavirus effect. The half maximal inhibitory concentrations of gossypol and (?)-gossypol to SARS-CoV proteases and SARS-CoV-2 3CL proteases are all lower than 10 ?M. The anti-Coronavirus 3CL protease effect is good. Therefore, the gossypol and its optical isomers have the potential for use in the preparation of a drug for preventing and/or treating novel Coronavirus infections.

Abstract: A method for checking an out-of-step of a synchronous motor includes detecting three-phase currents of the synchronous motor; determining whether a relationship between the three-phase currents satisfies a preset requirement; and if no, determining that the synchronous motor is out of step. It is determined that the synchronous motor is out of step when amplitudes of each current of the three-phase currents are not equal or when the phase difference between the three-phase currents is not 120°.

Abstract: The present invention relates to the field of medicinal chemistry, and in particular relates to 4-(five-membered heterocyclic pyrimidine/pyridine substituted) amino-1H-3-pyrazolecarboxamide derivatives, the preparation method thereof, pharmaceutical compositions containing these compounds and the medicinal use thereof, especially as protein kinase inhibitors for anti-tumor use.

Abstract: The present invention relates to the field of medicinal chemistry, and in particular relates to 4-(five-membered heterocyclic pyrimidine/pyridine substituted) amino-1H-3-pyrazolecarboxamide derivatives, the preparation method thereof, pharmaceutical compositions containing these compounds and the medicinal use thereof, especially as protein kinase inhibitors for anti-tumour use.

Abstract: A method for checking an out-of-step of a synchronous motor includes detecting three-phase currents of the synchronous motor; determining whether a relationship between the three-phase currents satisfies a preset requirement; and if no, determining that the synchronous motor is out of step. It is determined that the synchronous motor is out of step when amplitudes of each current of the three-phase currents are not equal or when the phase difference between the three-phase currents is not 120°.

Abstract: The present invention relates to a hybrid component and method capable of simultaneously combining and depolarizing two pump laser diodes of different wavelengths with linear polarized output. The beam combiner is a Wellstone prism which is used to combine two linear-polarized pumping beams, and the depolarizer has three different embodiments: a single stage high birefringent waveplate; two stages high birefringent waveplates; a quarter waveplate or a three-quarter waveplate plus a single stage high birefringent waveplate. The Polarization Beam Combiner (PBC) and the depolarizer are integrated into one single hybrid component, in which two orthogonal pumping lights with different wavelengths are combined and depolarized simultaneously. Therefore, the hybrid component and method makes it simpler and cheaper to design a Raman amplifier and will propel Raman amplifier market penetration in optical communication systems.

Abstract: The present invention relates to a hybrid component and method capable of simultaneously combining and depolarizing two pump laser diodes of different wavelengths with linear polarized output. The beam combiner is a Wellstone prism which is used to combine two linear-polarized pumping beams, and the depolarizer has three different embodiments: a single stage high birefringent waveplate; two stages high birefringent waveplates; a quarter waveplate or a three-quarter waveplate plus a single stage high birefringent waveplate. The Polarization Beam Combiner (PBC) and the depolarizer are integrated into one single hybrid component, in which two orthogonal pumping lights with different wavelengths are combined and depolarized simultaneously. Therefore, the hybrid component and method makes it simpler and cheaper to design a Raman amplifier and will propel Raman amplifier market penetration in optical communication systems.