Patents by Inventor Tapani Vihinen

Tapani Vihinen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Syndecan enhancer element and syndecan stimulation of cellular differentiation
    Patent number: 6492344
    Abstract: Methods are provided for altering levels of syndecan within a cell. The methods include enhancing syndecan expression via administration of growth factors, preventing suppression of syndecan expression via administration of anti-steroid agents, and altering syndecan biochemistry within the cell. The methods are used to induce or maintain cellular differentiation, and to decrease the growth of malignant cells. Application of the methods to the treatment of patients, including humans, is provided. A syndecan enhancer element, novel proteins that activate the enhancer element, non-human transgenic animals comprising this enhancer element linked to a structural gene, and the use of this enhancer element to regulate the expression of syndecan and other genes are also provided. The enhancer element can also be used to target expression of a gene to wound sites.
    Type: Grant
    Filed: June 21, 1999
    Date of Patent: December 10, 2002
    Assignee: Biotie Therapies Corp.
    Inventors: Markku Jalkanen, Panu Jaakkola, Tapani Vihinen
  • Syndecan enhancer element and syndecan stimulation of cellular differentiation
    Patent number: 6017727
    Abstract: A DNA enhancer element and the use of this syndecan enhancer element to regulate the expression of genes are provided.
    Type: Grant
    Filed: December 2, 1996
    Date of Patent: January 25, 2000
    Assignee: BioTie Therapies Ltd.
    Inventors: Markku Jalkanen, Panu Jaakkola, Tapani Vihinen
  • Syndecan stimulation of cellular differentiation
    Patent number: 5726058
    Abstract: Methods are provided for altering levels of syndecan within a cell. The methods include enhancing syndecan expression via administration of growth factors, preventing suppression of syndecan expression via administration of anti-steroid agents, and altering syndecan biochemistry within the cell. The methods are used to induce or maintain cellular differentiation, and to decrease the growth of malignant cells. Application of the methods to the treatment of patients, including humans, is provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 10, 1998
    Inventors: Markku Jalkanen, Leena Alanen-Kurki, Petri Auvinen, Panu Jaakkola, Sirpa Leppa, Markku Mali, Tapani Vihinen, Anni Warri