Abstract: A process for the preparation of controlled drug release porous hydroxyapatite microspheres, in the form of granules, consisting of interconnected pore channels with high porosity. It comprises the steps of mixing nano-hydroxyapatite powder with camphene to form a homogenous mixture followed by mixing said homogenous mixture with gelatin solution to form a complex mixture. This complex mixture is dispersed in cold stirring oil in a beaker until said dispersed granules hardens to form green bodies. These green bodies are subjected to heat treatment to obtain porous hydroxyapatite microspheres, subjecting the said porous hydroxyapatite microspheres to antibiotics encapsulation.