Patents by Inventor Tapomoy Bhattacharjee
Tapomoy Bhattacharjee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11964422Abstract: Described herein are various embodiments of a valve that may be opened and closed using a thixotropic or “stress yield” material, or other material that temporarily changes phase upon application of energy to the material. More particularly, some embodiments may include a valve that is opened and closed using a granular gel that is a temporary phase change material.Type: GrantFiled: April 30, 2021Date of Patent: April 23, 2024Assignee: University of Florida Research Foundation, Inc.Inventors: Joshua Muse, Meghan Hughes, Carl David Crane, Thomas Ettor Angelini, Kyle D. Schulze, Tapomoy Bhattacharjee, Wallace Gregory Sawyer, Curtis Taylor
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Patent number: 11879119Abstract: Disclosed herein is a bioreactor system that allows perfusive flow through a porous support medium enabling 3D growth of biological samples. In some embodiments, the system comprises a sample well filled with a three-dimensional (3D) cell growth medium. The system can further comprises a liquid medium reservoir fluidly connected to the sample well by a first filter material. The system can further comprises a medium collection chamber fluidly connected to the sample well by a second filter material. The system can further comprise an absorbant material that creates an osmotic pressure gradient to produce perfusive flow. In some embodiments, osmotic pressure draws fluid from the liquid medium reservoir, through the first filter material, into the sample well where it permeates the three-dimensional cell growth medium, through the second filter material, and finally into the medium collection chamber.Type: GrantFiled: August 1, 2019Date of Patent: January 23, 2024Assignee: University of Florida Research Foundation, Inc.Inventors: Thomas Ettor Angelini, Tapomoy Bhattacharjee, Wallace Gregory Sawyer, Cameron Morley
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Patent number: 11766823Abstract: A method or apparatus for creating a three-dimensional tissue construct of a desired shape for repair or replacement of a portion of an organism. The method may comprise injecting at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The apparatus may comprise an injector configured to inject at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The first material may comprise a yield stress material, which may be a material exhibiting Herschel-Bulkley behavior. The tissue construct may have a smallest feature size of ten micrometers or less.Type: GrantFiled: April 19, 2021Date of Patent: September 26, 2023Assignee: University of Florida Research Foundation, Inc.Inventors: Thomas Ettor Angelini, Wallace Gregory Sawyer, Kyle Gene Rowe, Tapomoy Bhattacharjee, Alberto Fernandez-Nieves, Ya-Wen Chang, Samantha M. Marquez
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Patent number: 11753538Abstract: An organic microgel system as support material for 3D printing of soft materials such as silicone and methods for manufacturing and using the organic microgel system are disclosed. In some embodiments, the organic microgel system comprises a plurality of microgel particles formed by blending a di-block copolymer and a tri-block copolymer in an organic solvent. The organic microgel system may allow high precision 3D printing of silicone objects with complex shapes.Type: GrantFiled: August 5, 2021Date of Patent: September 12, 2023Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.Inventors: Thomas Ettor Angelini, Brent S. Sumerlin, Christopher S. O'Bryan, Wallace Gregory Sawyer, Tapomoy Bhattacharjee
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Publication number: 20220403364Abstract: Disclosed is a 3D porous medium and a method of manufacture. The 3D porous medium includes (i) a support structure of transparent hydrogel particles or emulsion droplets, (ii) bacterial nutrient in open volumes between the transparent hydrogel particles, as well as within micropores in the transparent hydrogel particles, and (iii) bacterial cells within the open volumes in the support structure.Type: ApplicationFiled: April 28, 2020Publication date: December 22, 2022Applicant: The Trustees of Princeton UniversityInventors: Sujit Datta, Tapomoy Bhattacharjee
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Publication number: 20220333051Abstract: A three-dimensional cell growth medium is described. The cell growth medium may comprise hydrogel particles swollen with a liquid cell growth medium to form a granular gel yield stress material which undergoes a phase transformation from a solid phase to a liquid-like phase when an applied stress exceeds the yield stress. Cells may be placed in the three-dimensional cell growth medium according to any shape or geometry, and may remain in place within the three-dimensional cell growth medium.Type: ApplicationFiled: June 16, 2022Publication date: October 20, 2022Inventors: WALLACE GREGORY SAWYER, THOMAS ETTOR ANGELINI, STEVEN CRAIG GHIVIZZANI, TAPOMOY BHATTACHARJEE, GLYN DANIEL PALMER
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Patent number: 11390835Abstract: A three-dimensional cell growth medium is described. The cell growth medium may comprise hydrogel particles swollen with a liquid cell growth medium to form a granular gel yield stress material which undergoes a phase transformation from a solid phase to a liquid-like phase when an applied stress exceeds the yield stress. Cells may be placed in the three-dimensional cell growth medium according to any shape or geometry, and may remain in place within the three-dimensional cell growth medium.Type: GrantFiled: May 7, 2016Date of Patent: July 19, 2022Assignee: University of Florida Research Foundation, Inc.Inventors: Wallace Gregory Sawyer, Thomas Ettor Angelini, Steven Craig Ghivizzani, Tapomoy Bhattacharjee, Glyn Daniel Palmer
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Publication number: 20210363340Abstract: An organic microgel system as support material for 3D printing of soft materials such as silicone and methods for manufacturing and using the organic microgel system are disclosed. In some embodiments, the organic microgel system comprises a plurality of microgel particles formed by blending a di-block copolymer and a tri-block copolymer in an organic solvent. The organic microgel system may allow high precision 3D printing of silicone objects with complex shapes.Type: ApplicationFiled: August 5, 2021Publication date: November 25, 2021Inventors: Thomas Ettor Angelini, Brent S. Sumerlin, Christopher S. O'Bryan, Wallace Gregory Sawyer, Tapomoy Bhattacharjee
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Patent number: 11124644Abstract: An organic microgel system as support material for 3D printing of soft materials such as silicone and methods for manufacturing and using the organic microgel system are disclosed. In some embodiments, the organic microgel system comprises a plurality of microgel particles formed by blending a di-block copolymer and a tri-block copolymer in an organic solvent. The organic microgel system may allow high precision 3D printing of silicone objects with complex shapes.Type: GrantFiled: August 31, 2017Date of Patent: September 21, 2021Assignee: University of Florida Research Foundation, Inc.Inventors: Thomas Ettor Angelini, Brent S. Sumerlin, Christopher S. O'Bryan, Wallace Gregory Sawyer, Tapomoy Bhattacharjee
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Publication number: 20210252777Abstract: A method or apparatus for creating a three-dimensional tissue construct of a desired shape for repair or replacement of a portion of an organism. The method may comprise injecting at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The apparatus may comprise an injector configured to inject at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The first material may comprise a yield stress material, which may be a material exhibiting Herschel-Bulkley behavior. The tissue construct may have a smallest feature size of ten micrometers or less.Type: ApplicationFiled: April 19, 2021Publication date: August 19, 2021Inventors: Thomas Ettor ANGELINI, Wallace Gregory SAWYER, Kyle Gene ROWE, Tapomoy BHATTACHARJEE, Alberto FERNANDEZ-NIEVES, Ya-Wen CHANG, Samantha M. MARQUEZ
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Publication number: 20210245420Abstract: Described herein are various embodiments of a valve that may be opened and closed using a thixotropic or “stress yield” material, or other material that temporarily changes phase upon application of energy to the material. More particularly, some embodiments may include a valve that is opened and closed using a granular gel that is a temporary phase change material.Type: ApplicationFiled: April 30, 2021Publication date: August 12, 2021Inventors: Joshua Muse, Meghan Huges, Carl David Crane, Thomas Ettor Angelini, Kyle D. Schulze, Tapomoy Bhattacharjee, Wallace Gregory Sawyer, Curtis Taylor
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Patent number: 11027483Abstract: Described herein are various embodiments of a valve that may be opened and closed using a thixotropic or “stress yield” material, or other material that temporarily changes phase upon application of energy to the material. More particularly, some embodiments may include a valve that is opened and closed using a granular gel that is a temporary phase change material.Type: GrantFiled: September 2, 2016Date of Patent: June 8, 2021Assignee: University of Florida Research Foundation, Inc.Inventors: Joshua Muse, Meghan Hughes, Carl David Crane, Thomas Ettor Angelini, Kyle D. Schulze, Tapomoy Bhattacharjee, Wallace Gregory Sawyer, Curtis Taylor
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Publication number: 20210163867Abstract: Disclosed herein is a bioreactor system that allows perfusive flow through a porous support medium enabling 3D growth of biological samples. In some embodiments, the system comprises a sample well filled with a three-dimensional (3D) cell growth medium. The system can further comprises a liquid medium reservoir fluidly connected to the sample well by a first filter material. The system can further comprises a medium collection chamber fluidly connected to the sample well by a second filter material. The system can further comprise an absorbant material that creates an osmotic pressure gradient to produce perfusive flow. In some embodiments, osmotic pressure draws fluid from the liquid medium reservoir, through the first filter material, into the sample well where it permeates the three-dimensional cell growth medium, through the second filter material, and finally into the medium collection chamber.Type: ApplicationFiled: August 1, 2019Publication date: June 3, 2021Inventors: Thomas Ettor Angelini, Tapomoy Bhattacharjee, Wallace Gregory Sawyer, Cameron Morley
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Patent number: 11007705Abstract: A method or apparatus for creating a three-dimensional tissue construct of a desired shape for repair or replacement of a portion of an organism. The method may comprise injecting at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The apparatus may comprise an injector configured to inject at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The first material may comprise a yield stress material, which may be a material exhibiting Herschel-Bulkley behavior. The tissue construct may have a smallest feature size of ten micrometers or less.Type: GrantFiled: February 12, 2016Date of Patent: May 18, 2021Assignees: University of Florida Research Foundation, Inc., Georgia Tech Research CorporationInventors: Thomas Ettor Angelini, Wallace Gregory Sawyer, Kyle Gene Rowe, Tapomoy Bhattacharjee, Alberto Fernandez-Nieves, Ya-Wen Chang, Samantha M. Marquez
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Publication number: 20190070765Abstract: Described herein are various embodiments of a valve that may be opened and closed using a thixotropic or “stress yield” material, or other material that temporarily changes phase upon application of energy to the material. More particularly, some embodiments may include a valve that is opened and closed using a granular gel that is a temporary phase change material.Type: ApplicationFiled: September 2, 2016Publication date: March 7, 2019Inventors: JOSHUA MUSE, MEGHAN HUGHES, CARL DAVID CRANE, THOMAS ETTOR ANGELINI, KYLE D. SCHULZE, TAPOMOY BHATTACHARJEE, WALLACE GREGORY SAWYER, CURTIS TAYLOR
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Publication number: 20180258382Abstract: A biological cell and/or tissue growth apparatus operable to create, in a chamber of the apparatus, a three-dimensional (3D) cell culture and to interact with a 3D structure of the cells in the chamber to, for example, apply materials to and/or remove materials from the cells or the chamber. The apparatus may include equipment for printing the 3D cell culture in a 3D cell growth medium. The 3D cell growth medium may be a granular gel material that undergoes a temporary phase change in response to an applied stress, such as a thixotropic or “yield stress” material. The apparatus may be operated such that the 3D printing equipment “prints” the 3D cell culture by depositing cells at particular locations in the 3D cell growth medium.Type: ApplicationFiled: September 16, 2016Publication date: September 13, 2018Inventors: BENJAMIN G. KESELOWSKY, THOMAS ETTOR ANGELINI, WALLACE GREGORY SAWYER, TAPOMOY BHATTACHARJEE
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Publication number: 20180142194Abstract: A three-dimensional cell growth medium is described. The cell growth medium may comprise hydrogel particles swollen with a liquid cell growth medium to form a granular gel yield stress material which undergoes a phase transformation from a solid phase to a liquid-like phase when an applied stress exceeds the yield stress. Cells may be placed in the three-dimensional cell growth medium according to any shape or geometry, and may remain in place within the three-dimensional cell growth medium.Type: ApplicationFiled: May 7, 2016Publication date: May 24, 2018Applicant: University of Florida Research Foundation, Inc.Inventors: WALLACE GREGORY SAWYER, THOMAS ETTOR ANGELINI, STEVEN CRAIG GHIVIZZANI, TAPOMOY BHATTACHARJEE, GLYN DANIEL PALMER
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Publication number: 20180057682Abstract: An organic microgel system as support material for 3D printing of soft materials such as silicone and methods for manufacturing and using the organic microgel system are disclosed. In some embodiments, the organic microgel system comprises a plurality of microgel particles formed by blending a di-block copolymer and a tri-block copolymer in an organic solvent. The organic microgel system may allow high precision 3D printing of silicone objects with complex shapes.Type: ApplicationFiled: August 31, 2017Publication date: March 1, 2018Applicant: University of Florida Research Foundation, IncorporatedInventors: Thomas Ettor Angelini, Brent S. Sumerlin, Christopher S. O'Bryan, Wallace Gregory Sawyer, Tapomoy Bhattacharjee
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Publication number: 20180021140Abstract: A method or apparatus for creating a three-dimensional tissue construct of a desired shape for repair or replacement of a portion of an organism. The method may comprise injecting at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The apparatus may comprise an injector configured to inject at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The first material may comprise a yield stress material, which may be a material exhibiting Herschel-Bulkley behavior. The tissue construct may have a smallest feature size of ten micrometers or less.Type: ApplicationFiled: February 12, 2016Publication date: January 25, 2018Applicants: University of Florida Research Foundation, Inc., Georgia Tech Research CorporationInventors: Thomas Ettor Angelini, Wallace Gregory Sawyer, Kyle Gene Rowe, Tapomoy Bhattacharjee, Alberto Fernandez-Nieves, Ya-Wen Chang, Samantha M. Marquez