Patents by Inventor Tara Moore

Tara Moore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for the treatment of corneal dystrophies
    Patent number: 11987809
    Abstract: Methods and compositions for the treatment of a corneal dystrophy in a subject in need thereof are provided. In one aspect, the method includes the step of obtaining a plurality of stem cells comprising a nucleic acid mutation in a corneal dystrophy target nucleic acid from the subject and manipulating the nucleic acid mutation in one or more stem cells of the plurality of stem cells to correct the nucleic acid mutation, thereby forming one or more manipulated stem cells. The manipulated stem cells are isolated and then transplanted into the subject. In some embodiments, the nucleic acid mutation is manipulated using CRISPR system.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: May 21, 2024
    Assignee: Avellino Lab USA, Inc.
    Inventors: Tara Moore, Andrew Nesbit, Gene Lee, Sun-young Cho, Larry DeDionisio
  • CRISPR/CAS9 TARGETED EXCISION OF THE INTRONIC CTG18.1 TRINUCLEOTIDE REPEAT EXPANSION OF TCF4 AS A THERAPY IN FUCHS' ENDOTHELIAL CORNEAL DYSTROPHY
    Publication number: 20230407279
    Abstract: The present disclosure relates to Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR associated protein 9 (Cas9) systems, and methods of use thereof for gene editing.
    Type: Application
    Filed: March 29, 2023
    Publication date: December 21, 2023
    Inventor: Tara MOORE
  • CRISPR GENE EDITING FOR AUTOSOMAL DOMINANT DISEASES
    Publication number: 20220056440
    Abstract: The present disclosure relates to Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR associated protein (Cas) systems, and methods of use thereof for gene editing or for preventing, ameliorating or treating a disease associated with a gene mutation or single-nucleotide polymorphism (SNP) in a subject.
    Type: Application
    Filed: November 5, 2021
    Publication date: February 24, 2022
    Inventor: Tara Moore
  • CRISPR/CAS9 SYSTEMS, AND METHODS OF USE THEREOF
    Publication number: 20210222171
    Abstract: The present disclosure relates to Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR associate protein 9 (Cas9) systems, and methods of use thereof for gene editing.
    Type: Application
    Filed: February 26, 2021
    Publication date: July 22, 2021
    Inventors: Tara MOORE, Andrew NESBIT, Kathleen CHRISTIE
  • CRISPR/Cas9 Systems, and Methods of Use Thereof
    Publication number: 20210032612
    Abstract: The present disclosure relates to Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR associated protein 9 (Cas9) systems, and methods of use thereof for gene editing or for preventing, ameliorating or treating a disease associated with a gene mutation or single-nucleotide polymorphism (SNP) in a subject.
    Type: Application
    Filed: February 22, 2019
    Publication date: February 4, 2021
    Applicant: Avellino Lab USA, Inc.
    Inventor: Tara Moore
  • Methods for Detecting Alleles Associated with Keratoconus
    Publication number: 20200190587
    Abstract: Systems and methods for detecting single nucleotide polymorphisms (SNPs) associated with keratoconus (KC) in a sample from a subject are described.
    Type: Application
    Filed: April 27, 2018
    Publication date: June 18, 2020
    Applicant: Avellino Lab USA, Inc.
    Inventors: Larry DeDionisio, Tara Moore, Andrew Nesbit
  • TREATMENT OF OCULAR DISEASE
    Publication number: 20190231847
    Abstract: A treatment of ocular disease, and more specifically disorders of the cornea, using the polypeptide FKBP-L and peptide fragments thereof is provided.
    Type: Application
    Filed: June 21, 2017
    Publication date: August 1, 2019
    Applicant: ALMAC DISCOVERY LIMITED
    Inventor: Tara MOORE
  • SINGLE GUIDE RNA/CRISPR/CAS9 SYSTEMS, AND METHODS OF USE THEREOF
    Publication number: 20190185850
    Abstract: The present disclosure relates to single guide RNA (sgRNA), Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR associate protein 9 (Cas9) system, and methods of use thereof for preventing, ameliorating or treating corneal dystrophies.
    Type: Application
    Filed: August 21, 2017
    Publication date: June 20, 2019
    Applicant: Avellino Lab USA, Inc.
    Inventors: Tara Moore, Andrew Nesbit, David Courtney, Katie Christie, Gene Lee
  • Methods for the Treatment of Corneal Dystrophies
    Publication number: 20190085288
    Abstract: Methods and compositions for the treatment of a corneal dystrophy in a subject in need thereof are provided. In one aspect, the method includes the step of obtaining a plurality of stem cells comprising a nucleic acid mutation in a corneal dystrophy target nucleic acid from the subject and manipulating the nucleic acid mutation in one or more stem cells of the plurality of stem cells to correct the nucleic acid mutation, thereby forming one or more manipulated stem cells. The manipulated stem cells are isolated and then transplanted into the subject. In some embodiments, the nucleic acid mutation is manipulated using CRISPR system.
    Type: Application
    Filed: May 11, 2018
    Publication date: March 21, 2019
    Applicant: Avellino Lab USA, Inc.
    Inventors: Tara Moore, Andrew Nesbit, Gene Lee, Sun-young Cho, Larry DeDionisio