Patents by Inventor Tarek A. Samad

Tarek A. Samad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrrolo[2,3-d]pyrimidine derivatives
    Patent number: 10966980
    Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, pharmaceutical compositions containing them, and therapeutic uses thereof.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: April 6, 2021
    Assignee: Pfizer Inc.
    Inventors: Michael L. Vazquez, Neelu Kaila, Jamison B. Tuttle, Patrick Robert Verhoest, Matthew R. Reese, Karen J. Coffman, Tarek Samad, James M. Duerr, Simone Sciabola, Mihir D. Parikh
  • Nucleic acids encoding hemojuvelin fusion proteins and uses thereof
    Patent number: 10611820
    Abstract: The present invention provides a hemojuvelin (HJV) fusion protein (e.g., a human HJV.Fc) protein, polynucleotides and vectors encoding such proteins, and methods for making such proteins. Also provided are methods for treating iron-related disorders which include administration of a HJV fusion protein to a patient in need thereof.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: April 7, 2020
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Herbert Y. Lin, Jodie Babitt, Clifford J. Woolf, Tarek A. Samad
  • Hemojuvelin Fusion Proteins And Uses Thereof
    Publication number: 20180072790
    Abstract: The present invention provides a hemojuvelin (HJV) fusion protein (e.g., a human HJV.Fc) protein, polynucleotides and vectors encoding such proteins, and methods for making such proteins.
    Type: Application
    Filed: August 21, 2017
    Publication date: March 15, 2018
    Inventors: Herbert Y. Lin, Jodie Babitt, Clifford J. Woolf, Tarek A. Samad
  • DRG11-responsive (DRAGON) gene family
    Patent number: 9868782
    Abstract: This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein. Protein and nucleic acid sequences of human, murine, zebrafish, and C. elegans Dragon family members are also disclosed.
    Type: Grant
    Filed: October 26, 2011
    Date of Patent: January 16, 2018
    Assignee: The General Hospital Corporation
    Inventors: Clifford J. Woolf, Tarek A. Samad
  • Hemojuvelin fusion proteins and uses thereof
    Patent number: 9758567
    Abstract: The present invention provides a hemojuvelin (HJV) fusion protein (e.g., a human HJV.Fc) protein, polynucleotides and vectors encoding such proteins, and methods for making such proteins. Also provided are methods for treating iron-related disorders which include administration of a HJV fusion protein to a patient in need thereof.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: September 12, 2017
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Herbert Y. Lin, Jodie Babitt, Clifford J. Woolf, Tarek A. Samad
  • METHODS AND COMPOSITIONS TO REGULATE HEPCIDIN EXPRESSION
    Publication number: 20170183411
    Abstract: The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-? superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders.
    Type: Application
    Filed: December 12, 2016
    Publication date: June 29, 2017
    Inventors: Herbert Y. Lin, Jodie Babitt, Raymond T. Chung, Tarek A. Samad, Alan L. Schneyer, Clifford J. Woolf
  • Antibodies that specifically bind to DRG11-responsive (DRAGON) proteins
    Patent number: 9644027
    Abstract: This invention features antibodies that specifically bind to a murine Dragon family protein.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: May 9, 2017
    Assignee: The General Hospital Corporation
    Inventors: Clifford J. Woolf, Tarek A. Samad
  • Antibodies that specifically bind to DRG11-responsive (dragon) proteins
    Patent number: 9637539
    Abstract: This invention features antibodies that specifically bind to a human Dragon family protein.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: May 2, 2017
    Assignee: The General Hospital Corporation
    Inventors: Clifford J. Woolf, Tarek A. Samad
  • Methods and compositions to regulate hepcidin expression
    Patent number: 9556251
    Abstract: The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-? superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders.
    Type: Grant
    Filed: July 16, 2014
    Date of Patent: January 31, 2017
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Herbert Y. Lin, Jodie Babitt, Raymond T. Chung, Tarek A. Samad, Alan L. Schneyer, Clifford J. Woolf
  • DRG11-RESPONSIVE (DRAGON) GENE AND USES THEREOF
    Publication number: 20160319000
    Abstract: This invention features methods and compositions useful for treating and diseases caused by a dysregulation of the BMP/GDF branch of the TGF-? signaling pathway. Also disclosed are methods for identifying compounds useful for such therapy.
    Type: Application
    Filed: December 15, 2015
    Publication date: November 3, 2016
    Inventors: Clifford J. Woolf, Tarek A. Samad
  • Antibodies that specifically bind to DRG11-responsive (DRAGON) proteins
    Patent number: 9475868
    Abstract: This invention features antibodies that specifically bind to a Dragon family protein.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: October 25, 2016
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Clifford J. Woolf, Tarek A. Samad
  • Antibodies that specifically bind to DRG11-responsive (dragon) proteins
    Patent number: 9416177
    Abstract: This invention features antibodies that specifically bind to a human Dragon family protein.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: August 16, 2016
    Assignee: The General Hospital Corporation
    Inventors: Clifford J. Woolf, Tarek A. Samad
  • DRG11-RESPONSIVE (DRAGON) GENE FAMILY
    Publication number: 20160158316
    Abstract: This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein. Protein and nucleic acid sequences of human, murine, zebrafish, and C. elegans Dragon family members are also disclosed.
    Type: Application
    Filed: February 18, 2016
    Publication date: June 9, 2016
    Inventors: Clifford J. Woolf, Tarek A. Samad
  • PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES
    Publication number: 20160045508
    Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, pharmaceutical compositions containing them, and therapeutic uses thereof.
    Type: Application
    Filed: August 10, 2015
    Publication date: February 18, 2016
    Applicant: Pfizer Inc.
    Inventors: Michael L. VAZQUEZ, Neelu KAILA, Jamison B. TUTTLE, Patrick Robert VERHOEST, Matthew R. REESE, Karen J. COFFMAN, Tarek SAMAD, James M. DUERR, Simone SCIABOLA, Mihir D. PARIKH
  • Screening methods of BMP/GDF signaling modulators using DRG11-responsive (DRAGON) proteins
    Patent number: 9249454
    Abstract: This invention features methods and compositions useful for treating and diseases caused by a dysregulation of the BMP/GDF branch of the TGF-? signaling pathway. Also disclosed are methods for identifying compounds useful for such therapy.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: February 2, 2016
    Assignee: The General Hospital Corporation
    Inventors: Clifford J. Woolf, Tarek A. Samad
  • DRG11-responsive (dragon) polypeptides
    Patent number: 9193783
    Abstract: This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein. Protein and nucleic acid sequences of human, murine, zebrafish, and C. elegans Dragon family members are also disclosed.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: November 24, 2015
    Assignee: The General Hospital Corporation
    Inventors: Clifford J. Woolf, Tarek A. Samad
  • DRG11-RESPONSIVE (DRAGON) GENE FAMILY
    Publication number: 20150246964
    Abstract: This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein. Protein and nucleic acid sequences of human, murine, zebrafish, and C. elegans Dragon family members are also disclosed.
    Type: Application
    Filed: March 3, 2015
    Publication date: September 3, 2015
    Inventors: Clifford J. Woolf, Tarek A. Samad
  • DRG11-RESPONSIVE (DRAGON) GENE FAMILY
    Publication number: 20150239967
    Abstract: This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein. Protein and nucleic acid sequences of human, murine, zebrafish, and C. elegans Dragon family members are also disclosed.
    Type: Application
    Filed: March 3, 2015
    Publication date: August 27, 2015
    Inventors: Clifford J. Woolf, Tarek A. Samad
  • HEMOJUVELIN FUSION PROTEINS AND USES THEREOF
    Publication number: 20150139993
    Abstract: The present invention provides a hemojuvelin (HJV) fusion protein (e.g., a human HJV.Fc) protein, polynucleotides and vectors encoding such proteins, and methods for making such proteins. Also provided are methods for treating iron-related disorders which include administration of a HJV fusion protein to a patient in need thereof.
    Type: Application
    Filed: October 20, 2014
    Publication date: May 21, 2015
    Inventors: Herbert Y. Lin, Jodie Babitt, Clifford J. Woolf, Tarek A. Samad
  • METHODS AND COMPOSITIONS TO REGULATE HEPCIDIN EXPRESSION
    Publication number: 20150072927
    Abstract: The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-? superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders.
    Type: Application
    Filed: July 16, 2014
    Publication date: March 12, 2015
    Inventors: Herbert Y. Lin, Jodie Babitt, Raymond T. Chung, Tarek A. Samad, Alan L. Schneyer, Clifford J. Woolf