Patents by Inventor Tarek Samad

Tarek Samad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DRG11-RESPONSIVE (DRAGON) GENE AND USES THEREOF
    Publication number: 20100183608
    Abstract: This invention features methods and compositions useful for treating and diseases caused by a dysregulation of the BMP/GDF branch of the TGF-? signaling pathway. Also disclosed are methods for identifying compounds useful for such therapy.
    Type: Application
    Filed: June 22, 2009
    Publication date: July 22, 2010
    Inventors: Clifford J. Woolf, Tarek A. Samad, Esthar Bell, Ali Brivanlou
  • Human hemojuvelin (HJV) or dragon-like 1 (DL-1) polypeptides and variants and uses thereof
    Patent number: 7696156
    Abstract: This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein. Protein and nucleic acid sequences of human, murine, zebrafish, and C. elegans Dragon family members are also disclosed.
    Type: Grant
    Filed: April 11, 2007
    Date of Patent: April 13, 2010
    Assignee: The General Hospital Corporation
    Inventors: Clifford J. Woolf, Tarek A. Samad
  • Hemojuvelin or dragon-like 2 (DL-2) polypeptides and variants and uses thereof
    Patent number: 7696155
    Abstract: This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein. Protein and nucleic acid sequences of human, murine, zebrafish, and C. elegans Dragon family members are also disclosed.
    Type: Grant
    Filed: April 11, 2007
    Date of Patent: April 13, 2010
    Assignee: The General Hospital Corporation
    Inventors: Clifford J. Woolf, Tarek A. Samad
  • DRG11-Responsive (DRAGON) Gene Family
    Publication number: 20100055696
    Abstract: This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein. Protein and nucleic acid sequences of human, murine, zebrafish, and C. elegans Dragon family members are also disclosed.
    Type: Application
    Filed: July 27, 2009
    Publication date: March 4, 2010
    Inventors: Clifford J. Woolf, Tarek A. Samad
  • Human DRG11-responsive axonal guidance and outgrowth of neurite (dragon) proteins and variants thereof
    Patent number: 7659370
    Abstract: This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein. Protein and nucleic acid sequences of human, murine, zebrafish, and C. elegans Dragon family members are also disclosed.
    Type: Grant
    Filed: August 13, 2007
    Date of Patent: February 9, 2010
    Assignee: The General Hospital Corporation
    Inventors: Clifford J. Woolf, Tarek A. Samad
  • Methods and Compositions to Regulate Iron Metabolism
    Publication number: 20080260736
    Abstract: The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-? superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders.
    Type: Application
    Filed: February 16, 2006
    Publication date: October 23, 2008
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Herbert Y. Lin, Jodie Babitt, Raymond T. Chung, Tarek A. Samad, Alan L. Schneyer, Clifford J. Woolf
  • DRG11-responsive axonal guidance and outgrowth of neurite (DRAGON) gene family
    Publication number: 20080064853
    Abstract: This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein. Protein and nucleic acid sequences of human, murine, zebrafish, and C. elegans Dragon family members are also disclosed.
    Type: Application
    Filed: August 13, 2007
    Publication date: March 13, 2008
    Applicant: The General Hospital Corporation
    Inventors: Clifford Woolf, Tarek Samad
  • Methods for inhibiting pain
    Publication number: 20080026003
    Abstract: The invention provides methods for the treatment or prevention of pain. The invention also provides screening methods for determining whether a compound inhibits IL-1? activity in the central nervous system of a mammal.
    Type: Application
    Filed: January 4, 2007
    Publication date: January 31, 2008
    Applicant: The General Hospital Corporation
    Inventors: Clifford Woolf, Tarek Samad, Ru-Rong Ji
  • Human DRG11-Responsive Axonal Guidance and Outgrowth of Neurite (DRAGON) proteins and variants thereof
    Patent number: 7319138
    Abstract: This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein. Protein and nucleic acid sequences of human, murine, zebrafish, and C. elegans Dragon family members are also disclosed.
    Type: Grant
    Filed: April 17, 2003
    Date of Patent: January 15, 2008
    Assignee: The General Hospital Corporation
    Inventors: Clifford J. Woolf, Tarek A. Samad
  • DRG11-responsive axonal guidance and outgrowth of neurite (dragon) gene family
    Publication number: 20070259816
    Abstract: This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein. Protein and nucleic acid sequences of human, murine, zebrafish, and C. elegans Dragon family members are also disclosed.
    Type: Application
    Filed: April 11, 2007
    Publication date: November 8, 2007
    Applicant: The General Hospital Corporation
    Inventors: Clifford Woolf, Tarek Samad
  • DRG11-responsive axonal guidance and outgrowth of neurite (dragon) gene family
    Publication number: 20070231863
    Abstract: This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein. Protein and nucleic acid sequences of human, murine, zebrafish, and C. elegans Dragon family members are also disclosed.
    Type: Application
    Filed: April 11, 2007
    Publication date: October 4, 2007
    Applicant: The General Hospital Corporation
    Inventors: Clifford Woolf, Tarek Samad
  • DRG11-responsive (DRAGON) gene and uses thereof
    Publication number: 20060063208
    Abstract: This invention features methods and compositions useful for treating and diseases caused by a dysregulation of the BMP/GDF branch of the TGF-? signaling pathway. Also disclosed are methods for identifying compounds useful for such therapy.
    Type: Application
    Filed: August 2, 2005
    Publication date: March 23, 2006
    Inventors: Clifford Woolf, Tarek Samad, Esther Bell, Ali Brivanlou
  • DRG11-responsive (DRAGON) gene family
    Publication number: 20060035263
    Abstract: This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein. Protein and nucleic acid sequences of human, murine, zebrafish, and C. elegans Dragon family members are also disclosed.
    Type: Application
    Filed: September 19, 2005
    Publication date: February 16, 2006
    Applicant: The General Hospital Corporation
    Inventors: Clifford Woolf, Tarek Samad
  • Methods for inhibiting pain
    Publication number: 20040105859
    Abstract: The invention provides methods for the treatment or prevention of pain. The invention also provides screening methods for determining whether a compound inhibits IL-1&bgr; activity in the central nervous system of a mammal.
    Type: Application
    Filed: December 15, 2003
    Publication date: June 3, 2004
    Inventors: Clifford J Woolf, Tarek A Samad, Ru-Rong Ji
  • DRG11-responsive (dragon) gene family
    Publication number: 20040014141
    Abstract: This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein. Protein and nucleic acid sequences of human, murine, zebrafish, and C. elegans Dragon family members are also disclosed.
    Type: Application
    Filed: April 17, 2003
    Publication date: January 22, 2004
    Inventors: Clifford J. Woolf, Tarek A. Samad