Abstract: In general, the present disclosure is directed to an endovascular device. The device may include an outer body comprising a biocompatible polymeric material; and a core comprising a first layer and a second layer, wherein the first layer comprising an anti-contractile agent and the second layer comprising a second agent.

Abstract: System and method for providing diagnostic, imaging procedures and surgical laser treatments generating patterns of laser light on target tissue of a patient. The system includes aiming and treatment light beams originating from the same visible laser emitting diode, a scanner for generating patterns of points of light of the generated light, a controller, and a user interface that allows the user to select one of several possible point of light patterns, adjusts the point of light intensity and/or duration.

Abstract: A pulsatile perfusion bioreactor for culturing one or more engineered blood vessels having a lumen and a wall is provided. The bioreactor includes a chamber for holding the engineered blood vessel and cell culture media; a mechanical property monitoring system for measuring axial tensile stress and strain, circumferential tensile stress and strain, and/or shear stress imparted on the vessel wall; and a pump system for delivering cell culture media through the vessel lumen, wherein the vessel is exposed to a composite pressure waveform and a composite flow waveform as the media is delivered there through. The pump system includes a steady flow and peristaltic pumps. Further, the composite pressure and flow waveforms each include a mean component, a fundamental frequency component, and a second harmonic frequency component. The bioreactor also includes a computer interface for monitoring and adjusting the composite waveforms to maintain a predetermined stress level.

Abstract: A method and system for thermal and non-thermal laser treatments includes a visible laser source. A laser beam in the visible spectrum is generated by the visible laser source and produces a modulated laser output. Laser controls allows the user to generate the pulsed output with variable pulse characteristics to provide selective, localized and user controlled thermal and or non-thermal biological effects at a targeted tissues. This laser system modulates the delivered laser energy to produce accurate and selective targeting of the pigmented cells of the treated tissues to induce therapeutic effects via gentle warming of the cells without significant collateral damage to surrounding tissues.

Abstract: A pulsatile perfusion bioreactor for culturing one or more engineered blood vessels having a lumen and a wall is provided. The bioreactor includes a chamber for holding the engineered blood vessel and cell culture media; a mechanical property monitoring system for measuring axial tensile stress and strain, circumferential tensile stress and strain, and/or shear stress imparted on the vessel wall; and a pump system for delivering cell culture media through the vessel lumen, wherein the vessel is exposed to a composite pressure waveform and a composite flow waveform as the media is delivered there through. The pump system includes a steady flow and peristaltic pumps. Further, the composite pressure and flow waveforms each include a mean component, a fundamental frequency component, and a second harmonic frequency component. The bioreactor also includes a computer interface for monitoring and adjusting the composite waveforms to maintain a predetermined stress level.

Abstract: A pulsatile perfusion bioreactor for culturing one or more engineered blood vessels having a lumen and a wall is provided. The bioreactor includes a chamber for holding the engineered blood vessel and cell culture media; a mechanical property monitoring system for measuring axial tensile stress and strain, circumferential tensile stress and strain, and/or shear stress imparted on the vessel wall; and a pump system for delivering cell culture media through the vessel lumen, wherein the vessel is exposed to a composite pressure waveform and a composite flow waveform as the media is delivered there through. The pump system includes a steady flow and peristaltic pumps. Further, the composite pressure and flow waveforms each include a mean component, a fundamental frequency component, and a second harmonic frequency component. The bioreactor also includes a computer interface for monitoring and adjusting the composite waveforms to maintain a predetermined stress levels.

Abstract: An apparatus and method of use for tracking eye and head movement comprising (1) at least one optoelectronic array sensor or optical flow sensor formed of a plurality of optoelectronic sensor cells; (2) a body configured to support the optoelectronic array sensor with focusing means along with a source of light with collimating means in front of and in proximity to an eye of a user; (3) an optical focusing means to focus an image of the ocular surface of the user on the optoelectronic array sensor; (4) a focusing lens with a source of light; (5) a means to detect blinking; (6) a driver configured to receive signals from the sensor array to generate coordinate signals corresponding to changes in the position of the ocular surface relative to the sensor array; and (7) a means to detect user's additional input and gestures.

Abstract: System and method for providing diagnostic, imaging procedures and surgical laser treatments generating patterns of laser light on target tissue of a patient. The system includes aiming and treatment light beams originating from the same visible laser emitting diode, a scanner for generating patterns of points of light of the generated light, a controller, and a user interface that allows the user to select one of several possible point of light patterns, adjusts the point of light intensity and/or duration.

Abstract: System and method for providing diagnostic, imaging procedures and surgical laser treatments generating patterns of laser light on target tissue of a patient. The system includes aiming and treatment light beams originating from the same visible laser emitting diode, a scanner for generating patterns of points of light of the generated light, a controller, and a user interface that allows the user to select one of several possible point of light patterns, adjusts the point of light intensity and/or duration.

Abstract: A system for bending a surgical rod including a linear actuator and a rotational actuator is provided. The linear actuator is configured for moving the surgical rod along a linear direction of the system, and the rotational actuator is configured for rotating the surgical rod about the linear direction. A bending mechanism is also provided positioned downstream of the linear and rotational actuators configured for bending the surgical rod. A controller is operably connected to the linear and rotational actuators and the bending mechanism, the controller configured to activate the various components and bend the surgical rod into a desired three-dimensional shape.

Abstract: A method and system for thermal and non-thermal laser treatments includes a visible laser source. A laser beam in the visible spectrum is generated by the visible laser source and produces a modulated laser output. Laser controls allows the user to generate the pulsed output with variable pulse characteristics to provide selective, localized and user controlled thermal and or non-thermal biological effects at a targeted tissues. This laser system modulates the delivered laser energy to produce accurate and selective targeting of the pigmented cells of the treated tissues to induce therapeutic effects via gentle warming of the cells without significant collateral damage to surrounding tissues.

Abstract: A pulsatile perfusion bioreactor for culturing one or more engineered blood vessels having a lumen and a wall is provided. The bioreactor includes a chamber for holding the engineered blood vessel and cell culture media; a mechanical property monitoring system for measuring axial tensile stress and strain, circumferential tensile stress and strain, and/or shear stress imparted on the vessel wall; and a pump system for delivering cell culture media through the vessel lumen, wherein the vessel is exposed to a composite pressure waveform and a composite flow waveform as the media is delivered there through. The pump system includes a steady flow and peristaltic pumps. Further, the composite pressure and flow waveforms each include a mean component, a fundamental frequency component, and a second harmonic frequency component. The bioreactor also includes a computer interface for monitoring and adjusting the composite waveforms to maintain a predetermined stress levels.

Abstract: A system for bending a surgical rod including a linear actuator and a rotational actuator is provided. The linear actuator is configured for moving the surgical rod along a linear direction of the system, and the rotational actuator is configured for rotating the surgical rod about the linear direction. A bending mechanism is also provided positioned downstream of the linear and rotational actuators configured for bending the surgical rod. A controller is operably connected to the linear and rotational actuators and the bending mechanism, the controller configured to activate the various components and bend the surgical rod into a desired three-dimensional shape.

Abstract: System and method for providing diagnostic, imaging procedures and surgical laser treatments generating patterns of laser light on target tissue of a patient. The system includes aiming and treatment light beams originating from the same visible laser emitting diode, a scanner for generating patterns of points of light of the generated light, a controller, and a user interface that allows the user to select one of several possible point of light patterns, adjusts the point of light intensity and/or duration.

Abstract: Systems, apparatuses, and methods for a compact surgical device include a laser unit and one or more laser outlet assemblies. The laser unit has a power regulator, one or more diode laser assemblies, each having a single diode laser source, and a laser trigger mechanism. The laser unit can emit an aiming light beam and a treatment laser beam either both from the same single diode laser or from two separate single diode lasers. The beam can pass through the one or more laser outlet assemblies. The aiming light beam can have a first energy level. The treatment laser beam can have a second energy level that is substantially greater than the first energy level of the aiming light beam.

Abstract: Systems, apparatuses, and methods for a compact surgical device include a laser unit and one or more laser outlet assemblies. The laser unit has a power regulator, one or more diode laser assemblies, each having a single diode laser source, and a laser trigger mechanism. The laser unit can emit an aiming light beam and a treatment laser beam either both from the same single diode laser or from two separate single diode lasers. The beam can pass through the one or more laser outlet assemblies. The aiming light beam can have a first energy level. The treatment laser beam can have a second energy level that is substantially greater than the first energy level of the aiming light beam.

Abstract: A method for embolization treatment was developed in which microspheres with novel properties are administered in a mammal. The microspheres are made using a novel process that results in microspheres with new combined properties of high density, low fracture, high swell capacity, rapid swell, and deformability following swell. These microspheres form occlusions with high durability, withstanding over 100 mm Hg (13.3 kPa) of pressure.