Abstract: The present disclosure provides a rapid, scalable, and high-throughput method of identifying the precise regions in a receptor protein which are involved in binding of a molecule of interest. The method of the instant disclosure is useful where the crystal structure of a protein of interest is not available. Also provided are surface display libraries, and methods of making the same.

Abstract: The present disclosure provides a rapid, scalable, and high-throughput method of identifying the precise regions in a receptor protein which are involved in binding of a molecule of interest. The method of the instant disclosure is useful where the crystal structure of a protein of interest is not available. Also provided are surface display libraries, and methods of making the same.

Abstract: Methods, systems, and devices for combining an over-the-air broadcast signal with another digital media signal are described. Broadcast signals may be received at a user's location, demodulated, and then remodulated using the modulation scheme of a non-broadcast signal. The remodulated broadcast signal may then be combined with the non-broadcast signal, and the combined signal may be transmitted to a user's video equipment. In some cases, a channel guide interface may be provided that includes both the broadcast and non-broadcast media channels.

Abstract: The present invention is a method for performing a percutaneous laminoplasty that includes entering a first introducer needle introducing a first tool wire into an epidural space above a selected lamina, entering a first catcher exit needle that that is caught with the first introducer needle and pulled through a patient body and entering a second introducer needle introducing a second tool wire into the epidural space below the selected lamina. The method also includes entering a second catcher exit needle that is caught within the epidural space and pulled through the patient body, moving the caught first introducer needle and the first catcher exit needle back and forth to cut the lamina and moving the caught second introducer needle and the second catcher exit needle back and forth to cut the lamina. There is also a method for performing a percutaneous foraminoplasty.

Abstract: The present invention is a method for performing a percutaneous laminoplasty that includes entering a first introducer needle introducing a first tool wire into an epidural space above a selected lamina, entering a first catcher exit needle that that is caught with the first introducer needle and pulled through a patient body and entering a second introducer needle introducing a second tool wire into the epidural space below the selected lamina. The method also includes entering a second catcher exit needle that is caught within the epidural space and pulled through the patient body, moving the caught first introducer needle and the first catcher exit needle back and forth to cut the lamina and moving the caught second introducer needle and the second catcher exit needle back and forth to cut the lamina. There is also a method for performing a percutaneous foraminoplasty.

Abstract: Cable Television Operators (CTO) receives broadcast signals that are transmitted over the air under the Advanced Television System Committee (ATSC) standard in the form of 8VSB signals in digital format. The CTO converts, encrypts, and compresses the signals to either analog or QAM, IP, or other digital signal standards (QAM*), and transmits these signals through the cable plant or streaming video services to their customers. The QAM* signals lose video quality when they are encrypted and compressed to be sent through the cable plant or streamed. The local channels are broadcasted as digital off-air signals and are intercepted in the form of 8VSB signals. These 8VSB signals are converted into clear QAM* signal shown in FIG. 1. The clear QAM* signals have a higher video quality due to no encryption and compression. The clear and encrypted QAM* signals are combined and inserted into the video providers equipment (DVR, etc.) at the customer's premises shown in FIG. 2.

Abstract: The present invention provides a method for predicting the risk of a patient for developing adverse drug reactions, particularly 5-aminosalicylate nephrotoxicity (5-ASA nephrotoxicity). The invention also provides a method of identifying a subject afflicted with, or at risk of, developing 5-ASA nephrotoxicity. In some aspects, the methods comprise analyzing at least one genetic marker, wherein the presence of the at least one genetic marker indicates that the subject is afflicted with, or at risk of, developing 5-ASA nephrotoxicity.

Abstract: The present invention provides a method for predicting the risk of a patient for developing adverse drug reactions, particularly thiopurine induced pancreatitis (TIP). The invention also provides a method of identifying a subject afflicted with, or at risk of, developing TIP. In some aspects, the methods comprise analyzing at least one genetic marker, wherein the presence of the at least one genetic marker indicates that the subject is afflicted with, or at risk of, developing TIP.

Abstract: The present invention is a method for performing a percutaneous laminoplasty that includes entering a first introducer needle introducing a first tool wire into an epidural space above a selected lamina, entering a first catcher exit needle that that is caught with the first introducer needle and pulled through a patient body and entering a second introducer needle introducing a second tool wire into the epidural space below the selected lamina. The method also includes entering a second catcher exit needle that is caught within the epidural space and pulled through the patient body, moving the caught first introducer needle and the first catcher exit needle back and forth to cut the lamina and moving the caught second introducer needle and the second catcher exit needle back and forth to cut the lamina. There is also a method for performing a percutaneous foraminoplasty.