Abstract: The present invention comprises a method for calibrating a droplet dispensing apparatus using acoustic energy to dispense a plurality of droplet sets of a liquid from a source container into a plurality of target containers, with each droplet set being comprised of one or more individual droplets of the liquid, and with a liquid level of the liquid in the source container being measured before each of the droplet sets are dispensed. The average droplet volume for the individual droplets in each of the droplet sets is then calculated by detecting the presence of an indicator, such as a fluorescent chemical. Once the average droplet volume has been calculated, it is determined if the average droplet volume for each droplet set is acceptable or not acceptable. Where the average droplet volume is determined to be not acceptable, an existing droplet dispensing parameter is changed to a new droplet dispensing parameter that will cause the average droplet volume for that droplet set to change.

Abstract: An apparatus for high-throughput screening and generation of chemical libraries. The apparatus comprises computer controlled mechanical displacement devices and storage queues capable of managing a large number of source well plates and target well plates. In one aspect of the invention, precession alignment mechanisms are provided for efficient transfer of liquid from source well plates to target well plates. The apparatus may be configured such that any source fluid in any of the source well plates may be transferred to any target location within any of the target well plates in any sequence defined by the user. The computer controller may track the location of all the source well plates and target well plates and allow user defined association of any source well with any target well in any order defined by the user, thus providing an effective platform for chemical and biochemical synthesis and screening.

Abstract: An apparatus for high-throughput screening and/or generation of chemical libraries. In one aspect of the invention, a database is provided to track various parameters related to the source fluids in the source containment structure. Tracking changes of the source fluids in each source well may allow efficient utilization of source fluid and may also facilitate the high-throughput fluid transfer process. In one variation, data related to fluid level in each source well is maintained such that proper positioning of acoustic wave focus may be achieved. In another aspect of the invention, a database associated with one or more source fluid containment structure is provided and updated during the fluid transfer process. A second database providing a mapping profile with information regarding which fluid is to be transferred to what target is also provided. A third database may be generated to track fluid information in the target well plates.

Abstract: An apparatus for high-throughput screening and generation of chemical libraries. The apparatus comprises computer controlled mechanical displacement devices and storage queues capable of managing a large number of source well plates and target well plates. In one aspect of the invention, precession alignment mechanisms are provided for efficient transfer of liquid from source well plates to target well plates. The apparatus may be configured such that any source fluid in any of the source well plates may be transferred to any target location within any of the target well plates in any sequence defined by the user. The computer controller may track the location of all the source well plates and target well plates and allow user defined association of any source well with any target well in any order defined by the user, thus providing an effective platform for chemical and biochemical synthesis and screening.

Abstract: An apparatus for high-throughput screening and/or generation of chemical libraries. In one aspect of the invention, a database is provided to track various parameters related to the source fluids in the source containment structure. Tracking changes of the source fluids in each source well may allow efficient utilization of source fluid and may also facilitate the high-throughput fluid transfer process. In one variation, data related to fluid level in each source well is maintained such that proper positioning of acoustic wave focus may be achieved. In another aspect of the invention, a database associated with one or more source fluid containment structure is provided and updated during the fluid transfer process. A second database providing a mapping profile with information regarding which fluid is to be transferred to what target is also provided. A third database may be generated to track fluid information in the target well plates.

Abstract: Disclosed is an apparatus for high-throughput non-contact liquid transfer. The high-throughput non-contact liquid transfer apparatus may be implemented for high-throughput biological, chemical and biochemical, synthesis and/or screening. In one variation, the apparatus comprise of an acoustic emitter, one or more X/Y linear stage with associated handling device, one or more storage queue, and an image detection system. The apparatus may be controlled by a centralized system controller with associated electronic and/or software. The apparatus may further be integrated within a frame with environment and safety enclosure. The system controller may control positioning of source vessel and target device relative to an acoustic emitter device. The system controller may also track the location of all the source well plates and target well plates, thus providing for user-defined association of any well on any source well plate with any well on any target well plate for liquid transfer.