Patents by Inventor Tarlochan S. Niijar

Tarlochan S. Niijar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Blood-brain barrier shuttles containing antibodies recognizing alpha-synuclein
    Patent number: 10562973
    Abstract: The invention provides blood-brain barrier shuttles comprising monoclonal antibody 5C1 and related antibodies linked to a monovalent binding entity for a blood-brain barrier receptor. The 5C1 antibody binds to an epitope within residues 118-126 of alpha-synuclein. The antibodies are useful, for example, for treating and/or diagnosing synucleinopathies including Lewy body diseases, such as Parkinson's disease, diffuse Lewy body disease (DLBD), Lewy body variant of Alzheimer's disease (LBV), Alzheimer's and Parkinson's disease comorbidity, and pure autonomic failure, as well as multiple system atrophy (MSA).
    Type: Grant
    Filed: April 8, 2015
    Date of Patent: February 18, 2020
    Assignees: Prothena Bioscience Limited, Hoffmann-LaRoche Inc.
    Inventors: Robin Barbour, Kate Dora Games-Thiel, Tarlochan S. Niijar, Wagner Zago, Olaf Mundigl, Jens Niewoehner, Georg Tiefenthaler