Abstract: A hybrid medical device is described having at least one synthetic biomaterial, and at least one treated biological tissue suitable for implantation attached to the biomaterial wherein the tissue provides a blood contact surface and the biomaterial provides structural support. The tissue and biomaterial are attached using a polymer and the polymer is chemically or mechanically attached to the tissue. The device may further include pharmaceutical compounds for delivery over time and radiopaque compounds for fluoroscopic visualization. In some devices the tissue may be treated to degrade over time or the tissue only partially degrades over time. The biomaterial may be polytetrafluoroethylene (PTFE). In one configuration the device is configured for use as a heart valve.