Abstract: A method of preparing micro-capsules. The active ingredient, preferably provided in the form of an acid salt dissolved in a basic aqueous solution, is emulsified into a polymer solution, preferably PLGA in a relatively volatile solvent such as dichloromethane, to create a water in oil emulsion. This emulsion is further emulsified into an aqueous solution having a pH of a between about 7.4 and 8.0 and most preferably between about 7.8 and 8.0 to create a water in oil in water solution. The polymer solvent is allowed to evaporate, causing the emulsified active ingredient and surrounding polymer matrix to precipitate, thereby forming the micro-capsules. The micro-capsules are separated from the suspension, washed and freeze dried. The method has a very high encapsulation efficiency, even at high loading rates. Additionally, the dissolution rate of the micro-particles produced by the method is very steady over a long period of time.

Abstract: Compositions are disclosed of combinations of small interfering RNAs (siRNA) that can inhibit the replication of hepatitis C virus (HCV) in liver cells, along with methods of co-administering the siRNAs to subjects. Further, methods are disclosed for improving the delivery of nucleic acids to the liver.

Abstract: The invention features core-shell microsphere compositions, hollow polymeric microspheres, and methods for making the microspheres. The microspheres are characterized as having a polymeric shell with consistent shell thickness.

Abstract: A method of preparing micro-capsules. The active ingredient, preferably provided in the form of an acid salt dissolved in a basic aqueous solution, is emulsified into a polymer solution, preferably PLGA in a relatively volatile solvent such as dichloromethane, to create a water in oil emulsion. This emulsion is further emulsified into an aqueous solution having a pH of a between about 7.4 and 8.0 and most preferably between about 7.8 and 8.0 to create a water in oil in water solution. The polymer solvent is allowed to evaporate, causing the emulsified active ingredient and surrounding polymer matrix to precipitate, thereby forming the micro-capsules. The micro-capsules are separated from the suspension, washed and freeze dried. The method has a very high encapsulation efficiency, even at high loading rates. Additionally, the dissolution rate of the micro-particles produced by the method is very steady over a long period of time.

Abstract: The invention features core-shell microsphere compositions, hollow polymeric microspheres, and methods for making the microspheres. The microspheres are characterized as having a polymeric shell with consistent shell thickness.

Abstract: The invention features core-shell microsphere compositions, hollow polymeric microspheres, and methods for making the microspheres. The microspheres are characterized as having a polymeric shell with consistent shell thickness.

Abstract: The invention features core-shell microsphere compositions, hollow polymeric microspheres, and methods for making the microspheres. The microspheres are characterized as having a polymeric shell with consistent shell thickness.