Abstract: The systems, devices, and methods described herein are directed to methods for producing a spatially barcoded surface using combinatorial synthesis techniques.

Abstract: A method and system of extracting borderless structure using image processing is disclosed. The method may include converting a received document into a binary image comprising a plurality of text characters. A first image is created comprising a plurality of text blobs by connecting text characters and merging the plurality of text blobs to create one or more text line blobs to generate a second image. Further the first image and the second image are compared to generate a third image comprising a plurality of gap blobs. The gap blobs are clustered into one or more groups to determine a localized region of interest (ROI). Further lines are identified within the ROI using pixel density and separated into rows and columns. The final output contains list of cell coordinates.

Abstract: A process for purification of antibody or fusion protein by affinity chromatography wherein the elution is performed with high salt concentration which reduce turbidity in protein mixture during neutralization steps. The present invention provides an improved process of purifying antibodies through affinity chromatography using high salt-based elution.

Abstract: Described herein are systems and methods for sorting and selecting cells by immobilizing or enclosing cells in degradable hydrogel chambers, including a method of sorting cells comprising: (a) providing a fluidics device comprising: (i) a channel comprising a surface, (ii) a spatial energy modulation element in optical communication with the surface, and (iii) a detector in optical communication with the surface and in operable association with the spatial energy modulating element, the detector identifying cells and determining positions thereof on the surface; (b) loading the channel with cells and one or more polymer precursors so that the cells are disposed on or adjacent to the surface; (c) immobilizing one or more cells selected based on one or more optical signals therefrom by synthesizing one or more gel structures enclosing each of the one or more cells by projecting light into the channel with the spatial energy modulating element such that the projected light causes cross-linking of the one or more

Abstract: An example of a flow cell includes a substrate, a plurality of chambers defined on or in the substrate, and a plurality of depressions defined in the substrate and within a perimeter of each of the plurality of chambers. The depressions are separated by interstitial regions. Primers are attached within each of the plurality of depressions, and a capture site is located within each of the plurality of chambers.

Abstract: Routines are used to connect bot queries entered via a bot interface and database queries executed on a database. Each routine is associated with routine configurations, including (a) query attributes associated with bot queries that trigger the routine, (2) a database query executed or to be executed for the routine, and/or (3) display settings for displaying information returned from the database query in a bot response. Each routine is configured to generate an output structured data object (SDO) indicating information returned from the database query and the display settings applicable to the information. The output SDOs from the various routines are transmitted to the bot application via a single API endpoint. The routine configurations are entered by a design user through one or more design user interfaces rendered by an integrative configuration application module.

Abstract: A mounting system includes a strut channel, a holder clamp configured to connect with the strut channel, and a support clamp configured to secure the holder clamp. The holder clamp is movable in a vertical direction within the support clamp.

Abstract: A repository of replicated chunk files is analyzed to identify chunk files that meet at least a portion of combination criteria. Selected chunk files are associated together under a data protection grouping container. Erasure coding is applied to the data protection grouping container including by utilizing the selected chunk files as different data stripes of the erasure coding and generating one or more parity stripes based on the different data stripes.

Abstract: A clamp assembly for securing a solar panel module includes a clamp base, a clip movably connected to the clamp base, and a biasing fastener extending through the clamp base and the clip. The biasing fastener is configured to bias the clip from the clamp base.

Abstract: A solar panel mounting system includes two base rails each having a south clamp, a north stanchion with a north clamp, and ballast rails connected thereto. The base rails are secured to a structure for the installation of solar panels through one or more roof pads. The ballast rails extend transverse to the base rails. The south clamp and north clamp are engaged to secure solar panels. The system also includes a wire management clip for managing wires of the solar installation.

Abstract: A fluid assembly includes a base and at least one first device. The base includes a single-piece body including a base outlet, a base inlet, and a first interface including a first interface inlet and a first interface outlet. The base also includes a first flow path segment formed within the single-piece body that extends from the base inlet to the first interface outlet. The base also includes a second flow path segment formed within the single-piece body that extends from first interface inlet. The base also includes a ground path disposed within the single-piece body. The first device is attachable to the first interface to fluidly connect a first device inlet to the first interface outlet and a second device outlet to the second interface inlet.

Abstract: An example method comprises receiving first historical data of a first time period and failure data, identifying at least some sensor data that was or potentially was generated during a first failure, removing the at least some sensor data to create filtered historical data, training a classification model using the filtered historical data, the classification model indicating at least one first classified state at a second period of time prior to the first failure indicated by the failure data, applying the classification model to second sensor data to identify a first potential failure state based on the at least one first classified state, the second sensor data being from a subsequent time period, generating an alert if the first potential failure state is identified based on at least a first subset of sensor signals generated during the subsequent time period, and providing the alert.

Abstract: The invention is directed to methods and systems for producing a surface coated with a plurality of spatial barcodes. In one aspect, beads carrying barcode oligonucleotides are disposed on a surface after which hydrogel chambers are synthesized around each bead and barcode oligonucleotides are released to be captured on the surface in the interiors of the chambers. Captured oligonucleotide barcodes are amplified and optionally sequenced to form a coating of spatial barcodes.

Abstract: A system and method to schedule inspections for a plurality of assets at a corresponding plurality of outdoor locations are described. The method includes retrieving location attributes of each of the plurality of assets, retrieving terrestrial geotagged images that include one or more of the plurality of assets, obtaining parameters associated with each of the plurality of assets based on information from the images, and determining risk factors associated with each of the plurality of assets based on the associated parameters and a failure mapping. The method also includes determining a risk score for each of the plurality of assets based on the corresponding risk factors, and scheduling inspections of the plurality of assets based on the risk score associated with each of the plurality of assets.

Abstract: The invention is directed to methods and systems for carrying out one or more highly multiplexed cellular assays. In some embodiments, one or more channels of a fluidic device are provided with photopolymerizable polymer precursors and cells randomly disposed on a surface, after which positions of cells are measured by a detector, hydrogel chambers are synthesized by photopolymerization to enclose individual cells, and channels are loaded with assay reagents. Assay signals indicative of desired cellular characteristics can be generated for each of the enclosed cells.

Abstract: Routines are used to connect bot queries entered via a bot interface and database queries executed on a database. Each routine is associated with routine configurations, including (a) query attributes associated with bot queries that trigger the routine, (2) a database query executed or to be executed for the routine, and/or (3) display settings for displaying information returned from the database query in a bot response. Each routine is configured to generate an output structured data object (SDO) indicating information returned from the database query and the display settings applicable to the information. The output SDOs from the various routines are transmitted to the bot application via a single API endpoint. The routine configurations are entered by a design user through one or more design user interfaces rendered by an integrative configuration application module.

Abstract: A system and method of managing a network that includes assets are described. The method includes modeling the network as a directed graph with each of the assets represented as a node and determining alternative paths to each node from each available corresponding source of the node. The method also includes computing upstream robustness of each node, computing upstream robustness of the network, and computing downstream criticality of each node. Managing the network and each asset of the network is based on the upstream robustness and the downstream criticality of each node.

Abstract: Resetting an integrated circuit (IC) by reset circuit of the IC comprises receiving a clock signal and a data signal. A sequence of bits of the data signal is stored in a memory based on the clock signal. A test mode signal is received and the sequence of bits is decoded in response to receiving the test mode signal. One of adjusting a counter value of a counter of the reset circuitry and outputting a reset signal corresponding to the counter value is performed based on the decoded sequence of bits.

Abstract: The invention provides a process of purification of antibody or fusion protein from protein mixture comprising product and process related impurities. The process provides the use of hydroxyapatite chromatography for the separation of low molecular weight impurities and basic variants. In addition, invention further provides a scalable purification process to remove product and process related impurities.

Abstract: An example of a flow cell includes a substrate, a plurality of chambers defined on or in the substrate, and a plurality of depressions defined in the substrate and within a perimeter of each of the plurality of chambers. The depressions are separated by interstitial regions. Primers are attached within each of the plurality of depressions, and a capture site is located within each of the plurality of chambers.