Abstract: The present invention relates to a CPT-bound compound or a pharmaceutically acceptable salt thereof, the CPT-bound compound being obtained by binding CPT (or a CPT derivative) and guanidine to a reduced monosaccharide. The CPT-bound compound enhances solubility and cell permeability of the CPT drug, which makes it possible to effectively deliver CPT to target cells. Therefore, a pharmaceutical composition comprising, as an active ingredient, the CPT-bound compound or a pharmaceutically acceptable salt thereof is expected to be able to effectively treat cancer, in particular, colorectal cancer, even with a low dose of CPT.

Abstract: A process for forming a capped poly(arylene ether) copolymer, the process comprising: combining an acid catalyst and an uncapped poly(arylene ether) composition comprising an uncapped poly(arylene ether) copolymer comprising a phenolic end group ortho-substituted with a (C1-C12-hydrocarbyl)(C1-C12-hydrocarbyl)aminomethylene group, to form a first reaction mixture; reacting the (C1-C12-hydrocarbyl)(C1-C12-hydrocarbyl)aminomethylene group of the uncapped poly(arylene ether) copolymer in the presence of the acid catalyst under conditions effective to cleave a (C1-C12-hydrocarbyl)(C1-C12-hydrocarbyl)amino group from the uncapped poly(arylene ether) copolymer, to form a second reaction mixture; adding a nucleophilic catalyst and a capping agent to the second reaction mixture; and reacting the capping agent and the uncapped poly(arylene ether) copolymer under conditions effective to provide a product mixture comprising the capped poly(arylene ether) copolymer; preferably wherein the (C1-C6-hydrocarbyl)(C1-C6-hydroc

Abstract: A method for the manufacture of a bis(ether anhydride) comprises contacting an N-substituted bis(ether phthalimide) with a base under conditions effective to ring open the imides to provide a ring-opened product; and contacting the ring-opened product with an acid under conditions effective to provide a composition comprising the bis(ether anhydride).

Abstract: A process for the purification of an oxydiphthalic anhydride includes contacting a mixture of an oxydiphthalic anhydride and at least one of the corresponding oxydiphthalic diacid, a corresponding oxydiphthalic tetraacid, a halophthalic anhydride, and a catalyst with a solvent to provide a slurry. The solvent is capable of solubilizing the corresponding oxydiphthalic diacid, the corresponding oxydiphthalic tetraacid, the halophthalic anhydride, and the catalyst at a temperature of 15 to 50° C., and the oxydiphthalic anhydride is substantially insoluble in the solvent at this temperature. The oxydiphthalic anhydride can be isolated from the slurry. A purified oxydiphthalic anhydride and a polyetherimide prepared therefrom are also disclosed.

Abstract: The present invention relates to a CPT-bound compound or a pharmaceutically acceptable salt thereof, the CPT-bound compound being obtained by binding CPT (or a CPT derivative) and guanidine to a reduced monosaccharide. The CPT-bound compound enhances solubility and cell permeability of the CPT drug, which makes it possible to effectively deliver CPT to target cells. Therefore, a pharmaceutical composition comprising, as an active ingredient, the CPT-bound compound or a pharmaceutically acceptable salt thereof is expected to be able to effectively treat cancer, in particular, colorectal cancer, even with a low dose of CPT.

Abstract: A thermosetting oligomer is disclosed, comprising repeat units of the formula wherein Ar is a C6-32 arylene, preferably a C13-17 diarylene methylene; Ra and Rb at each occurrence are each independently a halogen, C1-12 alkyl, C2-12 alkenyl, C3-8 cycloalkyl, or C1-12 alkoxy, preferably a C1-3 alkyl; R3 at each occurrence is independently a halogen or a C1-6 alkyl group, preferably a C1-3 alkyl; R4 a C1-25 hydrocarbyl, preferably a C1-6 alkyl, a phenyl, or a phenyl substituted with up to five C1-6 alkyl groups, more preferably a C1-3 alkyl or a phenyl; and c, p and q at each occurrence are each independently 0 to 4.

Abstract: A process for the purification of an oxydiphthalic anhydride includes contacting a mixture of an oxydiphthalic anhydride and at least one of the corresponding oxydiphthalic diacid, a corresponding oxydiphthalic tetraacid, a halophthalic anhydride, and a catalyst with a solvent to provide a slurry. The solvent is capable of solubilizing the corresponding oxydiphthalic diacid, the corresponding oxydiphthalic tetraacid, the halophthalic anhydride, and the catalyst at a temperature of 15 to 50° C., and the oxydiphthalic anhydride is substantially insoluble in the solvent at this temperature. The oxydiphthalic anhydride can be isolated from the slurry. A purified oxydiphthalic anhydride and a polyetherimide prepared therefrom are also disclosed.

Abstract: A method for the manufacture of a bis(ether anhydride) comprises contacting an N-substituted bis(ether phthalimide) with a base under conditions effective to ring open the imides to provide a ring-opened product; and contacting the ring-opened product with an acid under conditions effective to provide a composition comprising the bis(ether anhydride).