Abstract: Compounds of formula: are useful as antitumor agents. In these compounds, R10 is (a) (C1-C10) hydrocarbyl, (C1-C10)halohydrocarbyl, (C1-C6)hydroxyalkyl, or or R10 is (b) in which Q and A are linkers and Ar is optionally substituted monocyclic or bicyclic aryl or heteroaryl.

Abstract: An example of a flow cell includes a substrate, a plurality of chambers defined on or in the substrate, and a plurality of depressions defined in the substrate and within a perimeter of each of the plurality of chambers. The depressions are separated by interstitial regions. Primers are attached within each of the plurality of depressions, and a capture site is located within each of the plurality of chambers.

Abstract: A system and a method to allocate data to a first cache increments a first counter if a reuse indicator for the data indicates that the data is likely to be reused and decremented the counter if the reuse indicator for the data indicates that the data is likely not to be reused. A second counter is incremented upon eviction of the data from the second cache, which is a higher level cache than the first cache. The data is allocated to the first cache if the value of the first counter is equal to or greater than the first predetermined threshold or the value of the second counter equals zero, and the data is bypassed from the first cache if the value of the first counter is less than the first predetermined threshold and the value of the second counter is not equal to zero.

Abstract: A system of reducing transmissions of packetized data in a voice activated data packet based computer network environment is provided. A natural language processor component can parse an input audio signal to identify a request and a trigger keyword. Based on the input audio signal, a direct action application programming interface can generate a first action data structure, and a content selector component can select a content item. An interface management component can identify candidate interfaces and determine if prior instances of the packetized data was transmitted to the candidate interfaces. The interface management component can prevent the transmission of the packetized data if determined to be redundant.

Abstract: The present disclosure relates to systems, non-transitory computer-readable media, and methods that utilize adaptive, real-time filtration for identifying and providing on-screen control points within a digital canvas for modifying vector objects. In particular, the disclosed systems can generate bounding shapes for control points of a vector object. Based on positions and control orders of the bounding shapes, the disclosed systems can generate a three-dimensional data structure for selectively determining obscurity metrics for control points. For example, the disclosed systems selectively determine obscurity metrics by traversing root and/or child nodes of the three-dimensional data structure that correspond to overlapping bounding shapes of certain control orders.

Abstract: Systems, methods, and compositions provided herein relate to preparation of beads encapsulating long DNA fragments for high-throughput spatial indexing. Some embodiments include preparation of nucleic acid libraries within the bead, wherein the bead includes pores that allow diffusion of reagents while retaining genetic material.

Abstract: An embodiment of a semiconductor apparatus may include technology to receive data with a unique identifier, and bypass encryption logic of a media controller based on the unique identifier. Other embodiments are disclosed and claimed.

Abstract: A framework for in-row cooling is described herein. The cooling system employs a fan unit with a plurality of smaller fans for improving the spread of air flowing through a V-shaped heat exchanger. The use of multiple smaller fans and the V-shaped heat exchanger enables the cooling system to be cooled using ambient temperature water or processed water at ambient temperature.

Abstract: A stack of fluidics layers of a microfluidic cartridge for sequencing nucleic acid molecules includes a sequencing chamber layer having a sequencing chamber area configured for carrying out clustering and sequencing reactions, and a sequencing chamber bottom layer disposed under the sequencing chamber layer. The sequencing chamber bottom layer has an opening configured to hold an image sensor with the image sensor having an active area disposed under the sequencing chamber area. The sequencing chamber area spans substantially all of the active area of the image sensor. The stack of fluidics layers includes a flexible printed circuit board (PCB) layer under the sequencing chamber bottom layer, and a fluidics channels layer disposed under the flexible PCB layer. The fluidics channels layer includes fluidics channels that are configured to deliver reactants to the sequencing chamber area. The fluidics channels do not substantially overlap with the active area of the image sensor.

Abstract: According to one general aspect, an apparatus may include a store stream detector configured to detect when the apparatus is streaming data to a memory system. The apparatus may also include a write generator configured to route a stream of data to either a near memory of the memory system or a far memory of the memory system based upon a cache threshold value and a size of the stream of data. The apparatus may be configured to dynamically vary the cache threshold value based upon a predetermined rule set, such that cache pollution caused by the stream of data is managed.

Abstract: This disclosure describes, in part, techniques to process audio signals to lessen the impact that wind and/or other environmental noise has upon the resulting quality of these audio signals. For example, the techniques may determine a level of wind and/or other noise in an environment and may determine how best to process the signals to lessen the impact of the noise, such that one or more users that hear audio based on output of the signals hear higher-quality audio.

Abstract: Techniques for build recovery from inter-code commit failure. A build error for a software project is identified. A first software module, with one or more errors related to the build error, is selected. A comparison software module for the first software module is identified. The comparison software module includes at least one of: (i) a sibling software module to the first software module or (ii) an earlier version of the first software module. A potential problem with the first software module, related to the build error, is determined based on comparing the first software module with the comparison software module. A solution to the potential problem is generated based on the first software module. The solution includes a modification to the software code of the first software module. The solution is applied by modifying the software code of the first software module.

Abstract: A dynamic application testing and scoring system that tests applications under various tenets and categorizes the applications to be published, to be further reviewed or rejected. The results from administering a plurality of tests to an application are analyzed by applying rulesets that pertain to criteria under each of the tenets. An application score is determined from the analysis using weights associated with the tenets, priority levels of the criteria and the severity levels of the rulesets. The application score identifies a position for the application on a scoring scale relative to two trust threshold values. The application is categorized based on the position. Feedback regarding the categorization is received and the trust threshold values on the scoring scale can be adjusted if the categorization in the feedback is different from the categorization produced by the scoring system.

Abstract: A method for rotary die cutting. The method may include providing, to an accumulator, an input comprising a melt. The method may include processing, by the accumulator utilizing a set of rolls, the melt to form a sheet of material. The method may include providing, from the accumulator, the sheet of material to a dandy roll. The method may include providing, from the dandy roll, the sheet of material to a rotary die. The method may include cutting, by the rotary die, a product from the sheet of material. The method may include providing, from the rotary die, the product to a stacker.

Abstract: This disclosure describes techniques for analyzing information generated as a result of monitoring resources within computing environments. In one example, this disclosure describes a method that includes observing a plurality of alerts generated in response to monitoring resources associated with a plurality of connected elements within a network; determining a plurality of occurrence counts; determining a plurality of concurrent occurrence counts, wherein each of the plurality of concurrent occurrence counts represents a count of concurrent occurrences of two or more of the alerts in the set of historical alerts; and identifying one or more root cause alerts, wherein the one or more root cause alerts are determined based on the plurality of occurrence counts and the plurality of the concurrent occurrence counts, and wherein the one or more root cause alerts are a subset of the plurality of alerts.

Abstract: Systems and methods of generating voice-based software applications are provided. A system can receive, from an application developer computing device, a request to build a voice-based software application. The system can select an application template from a plurality of application templates. The selected application template can include a module that corresponds to a function of the voice-based software application. The system can provide the selected application template to the application developer computing device. The system can receive, from the application developer computing device, an input for a field of the at least one module of the selected application template. The system can generate the voice-based software application based on the selected application template and the input for the at least one field of the at least one module of the selected application template.

Abstract: Techniques are described for performing inter-object interactions between vector objects to adjust the appearance of one vector object based on another vector object. For example, a vector object interaction framework may be implemented in which designers drag a vector object onto another vector object to trigger an interaction between the objects. Candidate interactions between pairs of object types may be pre-defined and stored in a suitable data structure. Thus, when one vector object is dragged onto a recipient vector object and a pause is detected, the object types for the dragged and recipient objects may be determined, and a corresponding set of candidate interactions for the pair of object types may be accessed, ranked, simulated, and/or presented as selectable previews. As such, one of the candidate interactions may be selected and executed to form one or more output vector objects that may be saved, exported, modified, and/or reused.

Abstract: A catalytic composite is formed of a catalytic layered assembly including a porous catalytic fluoropolymer film and one or more felt batts connected with the porous catalytic fluoropolymer film. At least one felt batt is positioned adjacent the upstream side of the porous catalytic fluoropolymer film to form the catalytic composite. The fluoropolymer film is perforated to allow for enhanced airflow therethrough while retaining the capability of catalyzing the reduction or removal of chemical species in fluid flowing through the catalytic composite.

Abstract: A method including steps of (a) providing an array of sites, wherein each site comprises a mixture of different nucleic acid templates; (b) extending primers hybridized to the different nucleic acid templates at each of the sites with different nucleotide analogs having different reversible blocking moieties, respectively, thereby producing different primer extension products at each site; (c) detecting the different primer extension products to distinguish the different nucleotide analogs at each site; and (d) removing the different reversible blocking moieties from the primer extension products at each of the sites using a first treatment that is selective for a first of the different reversible blocking moieties and a second treatment that is selective for a second of the different reversible blocking moieties.

Abstract: A method of making polycrystalline silicon (p-Si), including: depositing amorphous silicon to produce an amorphous silicon super-mesa; dehydrogenating the amorphous silicon; patterning the super-mesa to produce a patterned substrate; depositing a capping oxide layer on the amorphous silicon on the patterned substrate; heating the capped, patterned substrate to the crystallization temperature of the a-Si; and flash lamp annealing the patterned substrate with a xenon lamp to produce p-Si having at least one super-mesa, and the super-mesa having supersized grains. Also disclosed are p-Si articles and devices incorporating the articles, and an apparatus for making the p-Si articles.