Patents by Inventor Tassilo Hornung
Tassilo Hornung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230250437Abstract: Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.Type: ApplicationFiled: April 22, 2022Publication date: August 10, 2023Inventors: Valeriy Domenyuk, Tassilo Hornung, Heather O’Neill, Mark Miglarese, David Spetzler
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Publication number: 20220290124Abstract: Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.Type: ApplicationFiled: February 25, 2022Publication date: September 15, 2022Inventors: Valeriy Domenyuk, Tassilo Hornung, Mark Miglarese, David Spetzler
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Patent number: 11332748Abstract: Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.Type: GrantFiled: June 10, 2020Date of Patent: May 17, 2022Assignee: Caris Science, Inc.Inventors: Valeriy Domenyuk, Tassilo Hornung, Heather O'Neill, Mark Miglarese, David Spetzler
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Patent number: 11293017Abstract: Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.Type: GrantFiled: May 25, 2017Date of Patent: April 5, 2022Assignee: Caris Science, Inc.Inventors: Valeriy Domenyuk, Tassilo Hornung, Mark Miglarese, David Spetzler
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Publication number: 20210382059Abstract: Methods and compositions are provided for specific aptamers and aptamer pools that bind biomarkers of interest such as microvesicle surface antigens or functional fragments of microvesicle surface antigens. In various embodiments, aptamers of the invention are used in diagnostic, prognostic, or theranostic processes to screen a biological sample for the presence or levels of biomarkers such as microvesicles that are determined to provide a diagnostic, prognostic, or theranostic readout. The diagnosis, prognosis, or theranosis may be related to cancer or other diseases and disorders. The invention also provides methods and composition to facilitate aptamer library screening and aptamer detection methods.Type: ApplicationFiled: December 21, 2020Publication date: December 9, 2021Inventors: David Halbert, Valeriy Domenyuk, David Spetzler, Tassilo Hornung, Frank Schäfer, Nianqing Xiao
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Patent number: 10942184Abstract: Methods and compositions are provided for specific aptamers and aptamer pools that bind biomarkers of interest such as microvesicle surface antigens or functional fragments of microvesicle surface antigens. In various embodiments, aptamers of the invention are used in diagnostic, prognostic, or theranostic processes to screen a biological sample for the presence or levels of biomarkers such as microvesicles that are determined to provide a diagnostic, prognostic, or theranostic readout. The diagnosis, prognosis, or theranosis may be related to cancer or other diseases and disorders. The invention also provides methods and composition to facilitate aptamer library screening and aptamer detection methods.Type: GrantFiled: March 6, 2018Date of Patent: March 9, 2021Assignee: Caris Science, Inc.Inventors: David D. Halbert, Valeriy Domenyuk, David Spetzler, Tassilo Hornung, Frank Schafer, Nianqing Xiao
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Publication number: 20210062191Abstract: Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.Type: ApplicationFiled: June 10, 2020Publication date: March 4, 2021Inventors: Valeriy Domenyuk, Tassilo Hornung, Heather O'Neill, Mark Miglarese, David Spetzler
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Patent number: 10731166Abstract: Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.Type: GrantFiled: March 18, 2017Date of Patent: August 4, 2020Assignee: Caris Science, Inc.Inventors: Valeriy Domenyuk, Tassilo Hornung, Heather O'Neill, Mark Miglarese, David Spetzler
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Publication number: 20200032265Abstract: Methods and compositions are provided for oligonucleotides and libraries of oligonucleotides that bind targets of interest. The targets include cellular biomarkers of viral infection. The viral infection may be that of human immunodeficiency virus-1.Type: ApplicationFiled: September 27, 2017Publication date: January 30, 2020Inventors: Tassilo Hornung, Heather O'Neill, Mark Miglarese, David Spetzler
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Publication number: 20190367903Abstract: Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.Type: ApplicationFiled: May 25, 2017Publication date: December 5, 2019Inventors: Valeriy DOMENYUK, Tassilo HORNUNG, Mark MIGLARESE, David SPETZLER
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Publication number: 20190317099Abstract: Methods and compositions are provided for specific aptamers and aptamer pools that bind biomarkers of interest such as microvesicle surface antigens or functional fragments of microvesicle surface antigens. In various embodiments, aptamers of the invention are used in diagnostic, prognostic, or theranostic processes to screen a biological sample for the presence or levels of biomarkers such as microvesicles that are determined to provide a diagnostic, prognostic, or theranostic readout. The diagnosis, prognosis, or theranosis may be related to cancer or other diseases and disorders. The invention also provides methods and composition to facilitate aptamer library screening and aptamer detection methods.Type: ApplicationFiled: March 6, 2018Publication date: October 17, 2019Inventors: David Halbert, Valeriy Domenyuk, David Spetzler, Tassilo Hornung, Frank Schafer, Nianqing Xiao
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Publication number: 20190078093Abstract: Methods and compositions are provided to identify oligonucleotides that bind targets of interest. The targets include tissues, cells, circulating biomarkers such as microvesicles, including those derived from various diseases. The oligonucleotides can be used in diagnostic and therapeutic applications.Type: ApplicationFiled: March 18, 2017Publication date: March 14, 2019Inventors: Valeriy DOMENYUK, Tassilo HORNUNG, Heather O'NEILL, Mark MIGLARESE, David SPETZLER
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Patent number: 9958448Abstract: Methods and compositions are provided for specific aptamers and aptamer pools that bind biomarkers of interest such as microvesicle surface antigens or functional fragments of microvesicle surface antigens. In various embodiments, aptamers of the invention are used in diagnostic, prognostic, or theranostic processes to screen a biological sample for the presence or levels of biomarkers such as microvesicles that are determined to provide a diagnostic, prognostic, or theranostic readout. The diagnosis, prognosis, or theranosis may be related to cancer or other diseases and disorders. The invention also provides methods and composition to facilitate aptamer library screening and aptamer detection methods.Type: GrantFiled: October 23, 2013Date of Patent: May 1, 2018Assignee: Caris Life Sciences Switzerland Holdings GMBHInventors: David Halbert, Valeriy Domenyuk, David Spetzler, Tassilo Hornung, Frank Schafer, Nianqing Xiao
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Patent number: 9939443Abstract: Methods are provided for selecting aptamers that are specific to a target of interest from amongst a library of potential aptamer sequences. Aptamers disclosed can be used to detect and/or characterize biological entities of interest, e.g. microvesicles and/or surface antigens. Further disclosed are biomarkers that can be used for diagnosing different disorders including different types of cancer.Type: GrantFiled: December 19, 2013Date of Patent: April 10, 2018Assignee: Caris Life Sciences Switzerland Holdings GmbHInventors: David Spetzler, Valeriy Domenyuk, Tassilo Hornung, Günter Mayer, Michael Famulok
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Publication number: 20160069889Abstract: Methods are provided for selecting aptamers that are specific to a target of interest from amongst a library of potential aptamer sequences. Aptamers disclosed can be used to detect and/or characterize biological entities of interest, e.g. microvesicles and/or surface antigens. Further disclosed are biomarkers that can be used for diagnosing different disorders including different types of cancer.Type: ApplicationFiled: December 19, 2013Publication date: March 10, 2016Inventors: David SPETZLER, Valeriy DOMENYUK, Tassilo HORNUNG, Günter MAYER, Michael FAMULOK
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Publication number: 20160003835Abstract: Methods and compositions are provided for specific aptamers and aptamer pools that bind biomarkers of interest such as microvesicle surface antigens or functional fragments of microvesicle surface antigens. In various embodiments, aptamers of the invention are used in diagnostic, prognostic, or theranostic processes to screen a biological sample for the presence or levels of biomarkers such as microvesicles that are determined to provide a diagnostic, prognostic, or theranostic readout. The diagnosis, prognosis, or theranosis may be related to cancer or other diseases and disorders. The invention also provides methods and composition to facilitate aptamer library screening and aptamer detection methods.Type: ApplicationFiled: October 23, 2013Publication date: January 7, 2016Inventors: David HALBERT, Valeriy DOMENYUK, David SPETZLER, Tassilo HORNUNG, Frank SCHAFER, Nianqing XIAO
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Publication number: 20150301058Abstract: Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease, select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and to determine treatment efficacy. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes. These include nucleic acids, protein, and circulating structures such as vesicles, and nucleic acid-protein complexes. The invention provides methods of assessing microvesicles in a biological sample. The invention also provides an aptamer to a microvesicle surface antigen. The aptamer may be used for therapeutic purposes.Type: ApplicationFiled: November 26, 2013Publication date: October 22, 2015Inventors: Jorge Schettini, Tassilo Hornung, Daniel Holterman, David Spetzler