Patents by Inventor Tasuku Okamoto

Tasuku Okamoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for highly sensitive detection of protein-protein interaction
    Patent number: 9540678
    Abstract: The present invention intends to provide an assay system using split luciferase that has a remarkably high detection sensitivity. In an embodiment, binding of mutually binding first and second proteins is detected by preparing a first fusion protein comprising the first protein fused with a peptide having the amino acid sequence of amino acid SEQ ID NO: 1 and a second fusion protein comprising the second protein fused with a peptide having an amino acid sequence selected from the group consisting of amino acid SEQ ID NOS: 2 to 6, and allowing the first fusion protein to bind with the second fusion protein to form a complex, and detecting luminescence emitted from the complex.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: January 10, 2017
    Assignees: The University of Tokyo, Toyo Boseki Kabushiki Kaisha, ProbeX Inc.
    Inventors: Takeaki Ozawa, Naomi Misawa, Kenji Miura, Tasuku Okamoto, Shigeaki Nishii, Kenji Masuda
  • METHOD FOR HIGHLY SENSITIVE DETECTION OF PROTEIN-PROTEIN INTERACTION
    Publication number: 20140141416
    Abstract: The present invention intends to provide an assay system using split luciferase that has a remarkably high detection sensitivity. In an embodiment, binding of mutually binding first and second proteins is detected by preparing a first fusion protein comprising the first protein fused with a peptide having the amino acid sequence of amino acid SEQ ID NO: 1 and a second fusion protein comprising the second protein fused with a peptide having an amino acid sequence selected from the group consisting of amino acid SEQ ID NOS: 2 to 6, and allowing the first fusion protein to bind with the second fusion protein to form a complex, and detecting luminescence emitted from the complex.
    Type: Application
    Filed: January 31, 2014
    Publication date: May 22, 2014
    Applicants: The University of Tokyo, Toyo Boseki Kabushiki Kaisha, ProbeX Inc.
    Inventors: Takeaki OZAWA, Naomi MISAWA, Kenji MIURA, Tasuku OKAMOTO, Shigeaki NISHII, Kenji MASUDA
  • Method for highly sensitive detection of protein-protein interaction
    Patent number: 8470974
    Abstract: The present invention intends to provide an assay system using split luciferase that has a remarkably high detection sensitivity. In an embodiment, binding of mutually binding first and second proteins is detected by preparing a first fusion protein comprising the first protein fused with a peptide having the amino acid sequence of amino acid SEQ ID NO: 1 and a second fusion protein comprising the second protein fused with a peptide having an amino acid sequence selected from the group consisting of amino acid SEQ ID NOS: 2 to 6, and allowing the first fusion protein to bind with the second fusion protein to form a complex, and detecting luminescence emitted from the complex.
    Type: Grant
    Filed: May 28, 2010
    Date of Patent: June 25, 2013
    Assignees: The University of Tokyo, ProbeX Inc., Tokyo Boseki Kabushiki Kaisha
    Inventors: Takeaki Ozawa, Naomi Misawa, Kenji Miura, Tasuku Okamoto, Shigeaki Nishii, Kenji Masuda
  • METHOD FOR HIGHLY SENSITIVE DETECTION OF PROTEIN-PROTEIN INTERACTION
    Publication number: 20120190824
    Abstract: The present invention intends to provide an assay system using split luciferase that has a remarkably high detection sensitivity. In an embodiment, binding of mutually binding first and second proteins is detected by preparing a first fusion protein comprising the first protein fused with a peptide having the amino acid sequence of amino acid SEQ ID NO: 1 and a second fusion protein comprising the second protein fused with a peptide having an amino acid sequence selected from the group consisting of amino acid SEQ ID NOS: 2 to 6, and allowing the first fusion protein to bind with the second fusion protein to form a complex, and detecting luminescence emitted from the complex.
    Type: Application
    Filed: May 28, 2010
    Publication date: July 26, 2012
    Applicants: THE UNIVERSITY OF TOKYO, TOYO BOSEKI KABUSHIKI KAISHA, PROBEX INC.
    Inventors: Takeaki Ozawa, Naomi Misawa, Kenji Miura, Tasuku Okamoto, Shigeaki Nishii, Kenji Masuda
  • Method of treatment for diabetic neuropathy
    Patent number: 5981594
    Abstract: A method of treatment for diabetic neuropathy using combined administration of a formulation including as an active ingredient a prostaglandin I derivative, especially a prostaglandin I.sub.2 derivative with an anti-diabetic agent is applied to hypofunction of motor nerve and sensory nerve to which conventional anti-diabetic agents do not provide sufficient treatments, with nerve conduction velocities improved.
    Type: Grant
    Filed: March 10, 1998
    Date of Patent: November 9, 1999
    Assignee: Toray Industries, Inc.
    Inventors: Tasuku Okamoto, Masaharu Shiga, Koji Miyata, Yuji Kuwabara, Shigeru Aoki, Hajimu Kurumatani