Abstract: Provided herein are thiosuccinyl-crosslinked hemoglobin conjugates useful as blood replacement agents and therapeutic proteins, pharmaceutical compositions comprising the same and the methods of use and preparation thereof.

Abstract: Provided herein are thiosuccinyl-crosslinked hemoglobin conjugates useful as blood replacement agents and therapeutic proteins, pharmaceutical compositions comprising the same and the methods of use and preparation thereof.

Abstract: A blow molded container includes a main member comprising a top, a first side orthogonal to the top, a second side orthogonal to the top, an external wall, and an internal wall defining a tool cavity. A corner portion is defined as a portion of the main member and includes least a first layer and a second layer. The first layer forming at least a part of the external wall and the second layer forming at least a part of the internal wall. The first layer and the second layer are adhered together to along a predetermined pattern to form at least a first line segment and a second line segment on one of the internal wall or the external wall of the corner portion.

Abstract: A blow molded container includes a main member (20) forming a tool cavity. The main member (20) has an inner surface. The main member (20) further contains at least one corner portion (30) and at the corner portion (30), the main member (20) includes at least a first layer (40) and a second layer (42). The first layer (40) forming the inner surface, and the first layer (40) and the second layer (42) are affixed together along a predetermined pattern while being separated from each other elsewhere. The first layer (40) is formed with a first protruding part (143) along the predetermined pattern, and the second layer (42) is formed with a second protruding part (145) along the predetermined pattern. The first protruding part (143) and the second protruding part (145) are affixed together.

Abstract: A blow molded container includes a main member (20) forming a tool cavity. The main member (20) has an inner surface. The main member (20) further contains at least one corner portion (30) and at the corner portion (30), the main member (20) includes at least a first layer (40) and a second layer (42). The first layer (40) forming the inner surface, and the first layer (40) and the second layer (42) are affixed together along a predetermined pattern while being separated from each other elsewhere. The first layer (40) is formed with a first protruding part (143) along the predetermined pattern, and the second layer (42) is formed with a second protruding part (145) along the predetermined pattern. The first protruding part (143) and the second protruding part (145) are affixed together.

Abstract: A clamshell package includes a first clamshell portion having a first surface with a first edge, and a first chamber portion. A second clamshell portion is coupled to the first clamshell portion about a fold axis. The second clamshell portion has a second surface with a second edge, and a second chamber portion. A paper card includes a first card portion, a second card portion, and a connecting portion connecting the first card portion and the second card portion. The first card portion is coupled to the first surface. The second portion is coupled to the second surface. The first edge and second edge extend beyond a perimeter of the paper card. A hanging hole extends through the first clamshell portion, the second clamshell portion, and the paper card.

Abstract: A clamshell package includes a first clamshell portion having a first surface with a first edge, and a first chamber portion. A second clamshell portion is coupled to the first clamshell portion about a fold axis. The second clamshell portion has a second surface with a second edge, and a second chamber portion. A paper card includes a first card portion, a second card portion, and a connecting portion connecting the first card portion and the second card portion. The first card portion is coupled to the first surface. The second portion is coupled to the second surface. The first edge and second edge extend beyond a perimeter of the paper card. A hanging hole extends through the first clamshell portion, the second clamshell portion, and the paper card.

Abstract: A phase-locked loop (PLL) includes a final mixer on its output. The final mixer subtracts out a noise or error term from the PLL's output to reduce noise and jitter. A first mixer generates the error term by subtracting a feedback clock from the reference clock. This error term is near D.C. since the feedback and reference clocks are at the same frequency. When this error term is subtracted from the PLL output, a secondary maxima in the noise plot at the PLL's loop bandwidth is removed. A feedback counter receives the output of the voltage-controlled oscillator (VCO) before the final mixer. Outer-band noise created by the VCO is subtracted out by the final mixer, using the error term generated by the first mixer. The mixers reduce noise generated by the VCO or from other sources in the PLL.