Patents by Inventor Tatiana I. Samoylova

Tatiana I. Samoylova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230338462
    Abstract: Disclosed are recombinant bacteriophage constructs and related exogenous peptide sequences for generating immune responses against CD47. The disclosed recombinant phage constructs bind to antibodies against CD47 and can be administered to an animal to generate an immune response against CD47, including generating anti-CD47 antibodies. The disclosed recombinant phage may comprise an amino acid sequence of CD47, epitopic fragments, variants, or functional mimics thereof. Also disclosed are methods for making and selecting such recombinant phage constructs and compositions that comprise such constructs (e.g., compositions for inducing an immune response against CD47 including pharmaceutical or veterinary compositions used as vaccines). Also disclosed are recombinant polynucleotides comprising genomic nucleic acid of the recombinant phage constructs disclosed herein.
    Type: Application
    Filed: May 2, 2023
    Publication date: October 26, 2023
    Inventors: Tatiana I. SAMOYLOVA, Alexandre M. SAMOYLOV, Kenny V. BROCK, Anna M. COCHRAN, James W. GILLESPIE
  • Patent number: 11666624
    Abstract: Disclosed are recombinant bacteriophage constructs and related exogenous peptide sequences for generating immune responses against CD47. The disclosed recombinant phage constructs bind to antibodies against CD47 and can be administered to an animal to generate an immune response against CD47, including generating anti-CD47 antibodies. The disclosed recombinant phage may comprise an amino acid sequence of CD47, epitopic fragments, variants, or functional mimics thereof. Also disclosed are methods for making and selecting such recombinant phage constructs and compositions that comprise such constructs (e.g., compositions for inducing an immune response against CD47 including pharmaceutical or veterinary compositions used as vaccines). Also disclosed are recombinant polynucleotides comprising genomic nucleic acid of the recombinant phage constructs disclosed herein.
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: June 6, 2023
    Assignees: Auburn University, Edward Via College of Osteopathic Medicine—Auburn
    Inventors: Tatiana I. Samoylova, Alexandre M. Samoylov, Kenny V. Brock, Anna M. Cochran, James W. Gillespie
  • Publication number: 20210085750
    Abstract: Disclosed are recombinant bacteriophage constructs and related exogenous peptide sequences for generating immune responses against CD47. The disclosed recombinant phage constructs bind to antibodies against CD47 and can be administered to an animal to generate an immune response against CD47, including generating anti-CD47 antibodies. The disclosed recombinant phage may comprise an amino acid sequence of CD47, epitopic fragments, variants, or functional mimics thereof. Also disclosed are methods for making and selecting such recombinant phage constructs and compositions that comprise such constructs (e.g., compositions for inducing an immune response against CD47 including pharmaceutical or veterinary compositions used as vaccines). Also disclosed are recombinant polynucleotides comprising genomic nucleic acid of the recombinant phage constructs disclosed herein.
    Type: Application
    Filed: September 24, 2020
    Publication date: March 25, 2021
    Applicants: Auburn University, Edward Via College of Osteopathic Medicine - Auburn
    Inventors: Tatiana I. SAMOYLOVA, Alexandre M. SAMOYLOV, Kenny V. Brock, Anna M. Cochran, James W. Gillespie
  • Patent number: 8871901
    Abstract: Disclosed are methods, compositions, zona pellucida binding peptides and polypeptides, and expression vectors for use in species-specific immunocontraception of animals, which include landscape bacteriophage. The disclosed compositions may include immunogenic compositions or vaccines.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: October 28, 2014
    Assignee: Auburn University
    Inventors: Tatiana I. Samoylova, Nancy R. Cox, Alexandre M. Samoylov, Anna M. Cochran, Valery A. Petrenko
  • Publication number: 20140030283
    Abstract: Disclosed are methods, compositions, zona pellucida binding peptides and polypeptides, and expression vectors for use in species-specific immunocontraception of animals. The disclosed compositions may include immunogenic compositions or vaccines.
    Type: Application
    Filed: July 23, 2013
    Publication date: January 30, 2014
    Inventors: Tatiana I. Samoylova, Henry J. Baker, Nancy Cox, Stephen Ditchkoff, Kent Van Kampen
  • Patent number: 8492516
    Abstract: Disclosed are methods, compositions, zona pellucida binding peptides and polypeptides, and expression vectors for use in species-specific immunocontraception of animals. The disclosed compositions may include immunogenic compositions or vaccines.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: July 23, 2013
    Assignee: Auburn University
    Inventors: Tatiana I. Samoylova, Henry J. Baker, Nancy Cox, Stephen Ditchkoff, Kent Van Kampen
  • Publication number: 20120164165
    Abstract: Disclosed are methods, compositions, zona pellucida binding peptides and polypeptides, and expression vectors for use in species-specific immunocontraception of animals. The disclosed compositions may include immunogenic compositions or vaccines.
    Type: Application
    Filed: March 9, 2012
    Publication date: June 28, 2012
    Applicant: AUBURN UNIVERSITY
    Inventors: Tatiana I. Samoylova, Henry J. Baker, Nancy Cox, Stephen Ditchkoff, Kent Van Kampen
  • Publication number: 20120156215
    Abstract: Disclosed are recombinant bacteriophage constructs and related heterologous peptide sequences for contraception in animals. The disclosed recombinant phage constructs bind to antibodies against gonadotropin releasing hormone (GnRH) and can be administered to an animal to generate an immune response against GnRH, including generating anti-GnRH antibodies. The disclosed recombinant phage may comprise an amino acid sequence of gonadotropin releasing hormone (GnRH), epitopic fragments, variants, or functional mimics thereof. Also disclosed are methods for making and selecting such recombinant phage constructs and compositions that comprise such constructs (e.g., compositions for inducing an immune response against GnRH including pharmaceutical or veterinary compositions used as vaccines). Also disclosed are recombinant polynucleotides comprising genomic nucleic acid of the recombinant phage constructs disclosed herein.
    Type: Application
    Filed: June 21, 2011
    Publication date: June 21, 2012
    Applicant: Auburn University
    Inventors: Tatiana I. Samoylova, Valery A. Petrenko, Nancy R. Cox, Alexandre M. Samoylov
  • Patent number: 8158366
    Abstract: Disclosed are methods of identifying peptides and compositions that bind to oocytes of animals in a species-specific manner. The methods utilize phage libraries and oocytes isolated from target species and non-target species.
    Type: Grant
    Filed: April 7, 2009
    Date of Patent: April 17, 2012
    Assignee: Auburn University
    Inventors: Tatiana I. Samoylova, Henry J. Baker, Nancy Cox, Stephen Ditchkoff
  • Publication number: 20110311565
    Abstract: Disclosed are methods, compositions, zona pellucida binding peptides and polypeptides, and expression vectors for use in species-specific immunocontraception of animals, which include landscape bacteriophage. The disclosed compositions may include immunogenic compositions or vaccines.
    Type: Application
    Filed: March 22, 2011
    Publication date: December 22, 2011
    Applicant: AUBURN UNIVERSITY
    Inventors: Tatiana I. Samoylova, Nancy R. Cox, Alexandre M. Samoylov, Anna M. Cochran, Valery A. Petrenko
  • Patent number: 8057992
    Abstract: Disclosed are methods, compositions, and zona pellucida binding peptides and polypeptides for use in immunocontraception of canines and other animals. The disclosed compositions may include pharmaceutical compositions. Methods for identifying peptides that bind to intact oocytes also are provided, in particular methods for identifying peptides that bind to zona pellucida of intact oocytes.
    Type: Grant
    Filed: November 7, 2008
    Date of Patent: November 15, 2011
    Assignee: Auburn University
    Inventors: Tatiana I. Samoylova, Henry J. Baker, Brenda Griffin, Kristina Pendergrass, Ludmila P. Globa, M. Daniel Givens, Kay P. Riddell, Nancy Cox
  • Publication number: 20110044989
    Abstract: Disclosed are methods, compositions, zona pellucida binding peptides and polypeptides, and expression vectors for use in species-specific immunocontraception of animals. The disclosed compositions may include immunogenic compositions or vaccines.
    Type: Application
    Filed: April 7, 2009
    Publication date: February 24, 2011
    Applicant: Auburn University
    Inventors: Tatiana I. Samoylova, Henry J. Baker, Nancy Cox, Stephen Ditchkoff, Kent Van Kampen
  • Patent number: 7642063
    Abstract: A diagnostic technique for matching anti-cancer peptide drugs to the molecular profiles of individual cancer tumors, and a method using the technique for a patient-specific treatment of tumors in mammals. This strategy matches anti-cancer peptide drugs to the molecular profiles of individual tumors, and includes the development of two banks, both of which use the same targeting peptides. Targeting peptides are identified using biopsies or other tissue materials from multiple cancer patients and placed into two banks. For a bank of probes, targeting peptides are linked to a label such as a fluorescent or a radioisotope. For a bank of drugs, targeting peptides are linked to a cytotoxic peptide to form a “targeting peptide drug”. Peptide probes are used to establish molecular profiles of individual tumors. Based on these molecular profiles, a patient-specific combination of targeting drugs from the bank of peptide drugs is prepared and the patient is treated.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: January 5, 2010
    Assignee: Auburn University
    Inventors: Tatiana I. Samoylova, Henry J. Baker, Nancy R. Cox, Ludmila P. Globa, Nancy E. Morrison
  • Publication number: 20090280137
    Abstract: Disclosed are methods, compositions, and zona pellucida binding peptides and polypeptides for use in immunocontraception of canines and other animals. The disclosed compositions may include pharmaceutical compositions.
    Type: Application
    Filed: November 7, 2008
    Publication date: November 12, 2009
    Applicant: Auburn University
    Inventors: Tatiana I. Samoylova, Henry J. Baker, Brenda Griffin, Kristina Pendergrass, Ludmila P. Globa, M. Daniel Givens, Kay P. Riddell, Nancy Cox
  • Patent number: 7138238
    Abstract: Methods and compositions for evaluating the affinity of one or more ligands of interest are provided. In particular, a ligand sensor device (LSD) comprising a sensor coupled to a peptide of interest is provided. Assays using the LSD allow detection of ligand-peptide interactions directly in tissue samples and thus provide an in vitro assay to characterize peptide ligands. The LSD and assays find particular use in characterizing cell-specific peptides isolated from in vivo screening in animals to determine their suitability for use in human therapy.
    Type: Grant
    Filed: February 6, 2002
    Date of Patent: November 21, 2006
    Assignee: Auburn University
    Inventors: Vitaly Vodyanoy, Alexandre M. Samoylov, Tatiana I. Samoylova, Suram T. Pathirana
  • Patent number: 7094868
    Abstract: Compositions for use in characterization, diagnosis, prognosis, and therapy of cancer cells are provided. The compositions comprise peptides and variants thereof which were isolated based on their ability to selectively bind glioma cells.
    Type: Grant
    Filed: February 4, 2003
    Date of Patent: August 22, 2006
    Assignee: Auburn University
    Inventors: Tatiana I. Samoylova, Valery A. Petrenko, Nancy R. Cox, Nancy E. Morrison, Henry J. Baker, Ludmila P. Globa
  • Publication number: 20030216322
    Abstract: Compositions for use in characterization, diagnosis, prognosis, and therapy of cancer cells are provided. The compositions comprise peptides and variants thereof which were isolated based on their ability to selectively bind glioma cells.
    Type: Application
    Filed: February 4, 2003
    Publication date: November 20, 2003
    Applicant: Auburn University
    Inventors: Tatiana I. Samoylova, Valery A. Petrenko, Nancy R. Cox, Nancy E. Morrison, Henry J. Baker, Ludmila P. Globa
  • Publication number: 20030040466
    Abstract: Methods and compositions for evaluating the affinity of one or more ligands of interest are provided. In particular, a ligand sensor device (LSD) comprising a sensor coupled to a peptide of interest is provided. Assays using the LSD allow detection of ligand-peptide interactions directly in tissue samples and thus provide an in vitro assay to characterize peptide ligands. The LSD and assays find particular use in characterizing cell-specific peptides isolated from in vivo screening in animals to determine their suitability for use in human therapy.
    Type: Application
    Filed: February 6, 2002
    Publication date: February 27, 2003
    Inventors: Vitaly Vodyanoy, Alexandre M. Samoylov, Tatiana I. Samoylova, Suram T. Pathirana