Patents by Inventor Tatiana Pimenova

Tatiana Pimenova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of detecting nitrotyrosine and aminotyrosine residues of peptides and proteins
    Patent number: 7223606
    Abstract: Methods and compositions are disclosed for quantifying and/or identifying a nitroderivative compound, or a residue thereof, and are applicable for assessing in vivo nitrative stress and for aiding in diagnosis of mammalian pathologies such as asthma, atherosclerosis, Alzheimer's disease, inflammation, ischemia, Parkinson's disease, and cancer. A preferred method comprises a) providing a sample containing the nitroderivative compound, or residue thereof, in the form of a diazo compound or residue thereof; b) azo-coupling the diazo compound, or residue thereof, to a target compound capable of producing a signal, to yield an azo-coupled compound; c) isolating the nitroderivative compound, or residue thereof, or the azo-coupled compound; d) quantitating and/or detecting the signal, to yield a quantitation and/or detection result; and e) determining from the quantitation and/or detection result the identity and/or concentration of the nitroderivative compound, or residue thereof, in the sample.
    Type: Grant
    Filed: June 8, 2005
    Date of Patent: May 29, 2007
    Assignee: Board of Regents of the University of Texas System
    Inventors: Andrei Nedospasov, Nataliya Beda, Tatiana Pimenova, Emil Martin, Ferid Murad
  • Methods of detecting nitrotyrosine and aminotyrosine residues of peptides and proteins
    Publication number: 20060035385
    Abstract: Methods and compositions are disclosed for quantifying and/or identifying a nitroderivative compound, or a residue thereof, and are applicable for assessing in vivo nitrative stress and for aiding in diagnosis of mammalian pathologies such as asthma, atherosclerosis, Alzheimer's disease, inflammation, ischemia, Parkinson's disease, and cancer. A preferred method comprises a) providing a sample containing the nitroderivative compound, or residue thereof, in the form of a diazo compound or residue thereof; b) azo-coupling the diazo compound, or residue thereof, to a target compound capable of producing a signal, to yield an azo-coupled compound; c) isolating the nitroderivative compound, or residue thereof, or the azo-coupled compound; d) quantitating and/or detecting the signal, to yield a quantitation and/or detection result; and e) determining from the quantitation and/or detection result the identity and/or concentration of the nitroderivative compound, or residue thereof, in the sample.
    Type: Application
    Filed: June 8, 2005
    Publication date: February 16, 2006
    Inventors: Andrei Nedospasov, Nataliya Beda, Tatiana Pimenova, Emil Martin, Ferid Murad