Patents by Inventor Tatjana CORNU

Tatjana CORNU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biodegradable multilayer nanocapsules for the delivery of biologically active agents in target cells
    Patent number: 11957794
    Abstract: The present invention relates to a biodegradable multilayer nanocapsule for the delivery of at least one biologically active agent into at least one target cell consisting of at least two layers of at least two biodegradable polymers which are laid one onto the other and whereby the biologically active agent is layered onto a layer of a biodegradable polymer and covered with a further layer of a biodegradable polymer, whereby one biologically active agent is a nucleic acid.
    Type: Grant
    Filed: January 13, 2022
    Date of Patent: April 16, 2024
    Assignees: Albert-Ludwigs-Universitaet Freiburg, Queen Mary University of London
    Inventors: Gleb Sukhorukov, Irina Nazarenko, Yana Tarakanchikova, Toni Cathomen, Tatjana Cornu, Valentina Pennucci, Jamal Alzubi
  • MODIFIED CAS9 SYSTEM HAVING A DOMINANT NEGATIVE EFFECTOR ON NON-HOMOLOGOUS END-JOINING FUSED THERETO AND ITS USE FOR IMPROVED GENE EDITING
    Publication number: 20240043819
    Abstract: The present invention relates to modified Cas9 nuclease comprising a substantial part of a Cas9 nuclease and fused thereto at least one substantial part of a dominant negative effector on non-homologous end-joining selected from the group consisting of RNF168, 53BP1, Ku80 and DNA-PK which compete with NHEJ promoting factors and CtIP.
    Type: Application
    Filed: July 26, 2021
    Publication date: February 8, 2024
    Applicant: Albert-Ludwigs-Universitaet Freiburg
    Inventors: Claudio MUSSOLINO, Toni CATHOMEN, Tatjana CORNU, Antonio CARUSILLO
  • Sequence specific reagents targeting CCR5 in primary hematopoietic cells
    Patent number: 11767512
    Abstract: The invention pertains to the field of cell therapy and HIV treatments. It provides with highly specific reagents for reducing or inactivating expression of CCR5 in primate and human primary cells, especially under the form of TALE-nucleases. These reagents allow the production of safer primary hematopoietic cells made resistant to HIV, stem cells or differentiated cells, for their infusion into HIV patients.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: September 26, 2023
    Assignees: CELLECTIS, ALBERT-LUDWIGS-UNIVERSITAT FREIBURG
    Inventors: Toni Cathomen, Tatjana Cornu, Philippe Duchateau, Claudio Mussolino, Marianna Romito, Agnes Gouble
  • BIODEGRADABLE MULTILAYER NANOCAPSULES FOR THE DELIVERY OF BIOLOGICALLY ACTIVE AGENTS IN TARGET CELLS
    Publication number: 20220233462
    Abstract: The present invention relates to a biodegradable multilayer nanocapsule for the delivery of at least one biologically active agent into at least one target cell consisting of at least two layers of at least two biodegradable polymers which are laid one onto the other and whereby the biologically active agent is layered onto a layer of a biodegradable polymer and covered with a further layer of a biodegradable polymer, whereby one biologically active agent is a nucleic acid.
    Type: Application
    Filed: January 13, 2022
    Publication date: July 28, 2022
    Applicants: Albert-Ludwigs-Universitaet Freiburg, Queen Mary University of London
    Inventors: Gleb SUKHORUKOV, Irina NAZARENKO, Yana TARAKANCHIKOVA, Toni CATHOMEN, Tatjana CORNU, Valentina PENNUCCI, Jamal ALZUBI
  • Biodegradable multilayer nanocapsules for the delivery of biologically active agents in target cells
    Patent number: 11253482
    Abstract: The present invention relates to a biodegradable multilayer nanocapsule for the delivery of at least one biologically active agent into at least one target cell consisting of at least two layers of at least two biodegradable polymers which are laid one onto the other and whereby the biologically active agent is layered onto a layer of a biodegradable polymer and covered with a further layer of a biodegradable polymer, whereby one biologically active agent is a nucleic acid.
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: February 22, 2022
    Assignees: Albert-Ludwigs-Universitaet Freiburg, Queen Mary University of London
    Inventors: Gleb Sukhorukov, Irina Nazarenko, Yana Tarakanchikova, Toni Cathomen, Tatjana Cornu, Valentina Pennucci, Jamal Alzubi
  • NEW SEQUENCE SPECIFIC REAGENTS TARGETING CCR5 IN PRIMARY HEMATOPOIETIC CELLS
    Publication number: 20200392459
    Abstract: The invention pertains to the field of cell therapy and HIV treatments. It provides with highly specific reagents for reducing or inactivating expression of CCR5 in primate and human primary cells, especially under the form of TALE-nucleases. These reagents allow the production of safer primary hematopoietic cells made resistant to HIV, stem cells or differentiated cells, for their infusion into HIV patients.
    Type: Application
    Filed: April 13, 2018
    Publication date: December 17, 2020
    Inventors: Toni CATHOMEN, Tatjana CORNU, Philippe DUCHATEAU, Claudio MUSSOLINO, Marianna ROMITO, Agnes GOUBLE
  • BIODEGRADABLE MULTILAYER NANOCAPSULES FOR THE DELIVERY OF BIOLOGICALLY ACTIVE AGENTS IN TARGET CELLS
    Publication number: 20200375914
    Abstract: The present invention relates to a biodegradable multilayer nanocapsule for the delivery of at least one biologically active agent into at least one target cell consisting of at least two layers of at least two biodegradable polymers which are laid one onto the other and whereby the biologically active agent is layered onto a layer of a biodegradable polymer and covered with a further layer of a biodegradable polymer, whereby one biologically active agent is a nucleic acid.
    Type: Application
    Filed: July 25, 2018
    Publication date: December 3, 2020
    Applicants: Albert-Ludwigs-Universitaet Freiburg, Queen Mary University of London
    Inventors: Gleb SUKHORUKOV, Irina NAZARENKO, Yana TARAKANCHIKOVA, Toni CATHOMEN, Tatjana CORNU, Valentina PENNUCCI, Jamal ALZUBI