Patents by Inventor Tatsuji Nomura

Tatsuji Nomura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF PRODUCING AN ANTIBODY
    Publication number: 20140178408
    Abstract: The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor ?-chain gene-knockout mouse with the thus backcrossed mouse. It is usable for producing a human antibody and establishing a stem cell assay system, a tumor model and a virus-infection model.
    Type: Application
    Filed: September 20, 2013
    Publication date: June 26, 2014
    Applicant: Central Institute for Experimental Animals
    Inventors: Mamoru Ito, Kimio Kobayashi, Tatsutoshi Nakahata, Koichiro Tsuji, Sonoko Habu, Yoshio Koyanagi, Naoki Yamamoto, Kazuo Sugamura, Kiyoshi Ando, Tatsuji Nomura
  • Production of human antibodies using NOD/SCID/?mice
    Patent number: 8541033
    Abstract: The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor ?-chain gene-knockout mouse with the thus backcrossed mouse. It is usable for producing a human antibody and establishing a stem cell assay system, a tumor model and a virus-infection model.
    Type: Grant
    Filed: November 17, 2009
    Date of Patent: September 24, 2013
    Assignee: Central Institute for Experimental Animals
    Inventors: Mamoru Ito, Kimio Kobayashi, Tatsutoshi Nakahata, Koichiro Tsuji, Sonoko Habu, Yoshio Koyanagi, Naoki Yamamoto, Kazuo Sugamura, Kiyoshi Ando, Tatsuji Nomura
  • Method of Producing a Mouse Suitable for Engraftment, Differentiation and Proliferation of Heterologous Cells, Mouse Produced by This Method and Use of the Mouse
    Publication number: 20110010781
    Abstract: The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor ?-chain gene-knockout mouse with the thus backcrossed mouse. It is usable for producing a human antibody and establishing a stem cell assay system, a tumor model and a virus-infection model.
    Type: Application
    Filed: November 17, 2009
    Publication date: January 13, 2011
    Inventors: Mamoru Ito, Kimio Kobayashi, Tatsutoshi Nakahata, Koichiro Tsuji, Sonoko Habu, Yoshio Koyanagi, Naoki Yamamoto, Kazuo Sugamura, Kiyoshi Ando, Tatsuji Nomura
  • Method of constructing spinal injury model monkey and utilization thereof
    Patent number: 7753054
    Abstract: A method for creating a monkey model of spinal cord injury, which includes exposing the dura mater of the cervical cord of a monkey and applying a load on the dura mater; the thus-created monkey model of spinal cord injury; and a method for evaluating a therapeutic drug for spinal cord injury by use of this model. According to the present invention, it is possible to create a monkey which is close to the human and thus useful as a model of human spinal cord injury. This model enables proper evaluation of therapeutic effects of various drugs on spinal cord injury. Through use of this model, it has been confirmed for the first time that transplantation therapy of human neural stem cells is efficacious against spinal cord injury.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: July 13, 2010
    Assignees: Japan Science and Technology Agency, Keio University
    Inventors: Hideyuki Okano, Yoshiaki Toyama, Masaya Nakamura, Tatsuji Nomura, Yoshikuni Tanioka, Kiyoshi Ando, Yonehiro Kanemura
  • Methods for developing animal models
    Publication number: 20080289059
    Abstract: The invention concerns methods for the development of mutant animals, including genetically engineered animals and those carrying spontaneous mutations, as human disease models. In particular, the invention provides an integrated technology, including rigorous specifications and quality control, for the development of animal models that can serve as a living assay system, useful in biomedical research and in the development of human therapeutics.
    Type: Application
    Filed: July 11, 2008
    Publication date: November 20, 2008
    Inventor: Tatsuji Nomura
  • Integrated in vivo animal experimentation systems
    Publication number: 20070204354
    Abstract: The invention concerns methods for the development of mutant animals, including genetically engineered animals and those carrying spontaneous mutations, as human disease models. In particular, the invention provides an integrated technology, including rigorous specifications and quality control, for the development of animal models that can serve as a living assay system, useful in biomedical research and in the development of human therapeutics.
    Type: Application
    Filed: February 28, 2007
    Publication date: August 30, 2007
    Inventor: Tatsuji Nomura
  • Method of producing a mouse suitable for engraftment, differentiation and proliferation of heterologous cells, mouse produced by this method and use of the mouse
    Publication number: 20070011753
    Abstract: The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor ?-chain gene-knockout mouse with the thus backcrossed mouse. It is usable for producing a human antibody and establishing a stem cell assay system, a tumor model and a virus-infection model.
    Type: Application
    Filed: September 8, 2006
    Publication date: January 11, 2007
    Inventors: Mamoru Ito, Kimio Kobayashi, Tatsutoshi Nakahata, Koichiro Tsuji, Sonoko Habu, Yoshio Koyanagi, Naoki Yamamoto, Kazuo Sugamura, Kiyoshi Ando, Tatsuji Nomura
  • Method of producing a mouse suitable for the engraftment, differentiation and proliferation of heterologous cells, mouse produced by this method and use of the mouse
    Patent number: 7145055
    Abstract: The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor ?-chain gene-knockout mouse with the thus backcrossed mouse. It is usable for producing a human antibody and establishing a stem cell assay system, a tumor model and a virus-infection model.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: December 5, 2006
    Assignee: Central Institute for Experimental Animals
    Inventors: Mamoru Ito, Kimio Kobayashi, Tatsutoshi Nakahata, Koichiro Tsuji, Sonoko Habu, Yoshio Koyanagi, Naoki Yamamoto, Kazuo Sugamura, Kiyoshi Ando, Tatsuji Nomura
  • Method of constructing spinal injury model monkey and utilization thereof
    Publication number: 20050186545
    Abstract: A method for creating a monkey model of spinal cord injury, which includes exposing the dura mater of the cervical cord of a monkey and applying a load on the dura mater; the thus-created monkey model of spinal cord injury; and a method for evaluating a therapeutic drug for spinal cord injury by use of this model. According to the present invention, it is possible to create a monkey which is close to the human and thus useful as a model of human spinal cord injury. This model enables proper evaluation of therapeutic effects of various drugs on spinal cord injury. Through use of this model, it has been confirmed for the first time that transplantation therapy of human neural stem cells is efficacious against spinal cord injury.
    Type: Application
    Filed: November 26, 2002
    Publication date: August 25, 2005
    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: Hideyuki Okano, Yoshiaki Toyama, Masaya Nakamura, Tatsuji Nomura, Yoshikuni Tanioka, Kiyoshi Ando, Yonehiro Kanemura
  • Methods for developing animal models
    Publication number: 20030237104
    Abstract: The invention concerns methods for the development of mutant animals, including genetically engineered animals and those carrying spontaneous mutations, as human disease models. In particular, the invention provides an integrated technology, including rigorous specifications and quality control, for the development of animal models that can serve as a living assay system, useful in biomedical research and in the development of human therapeutics.
    Type: Application
    Filed: June 24, 2002
    Publication date: December 25, 2003
    Inventor: Tatsuji Nomura
  • Method of constructing mouse suitable for the take, differentiation and proliferation of heterogenous cells, mouse constructed by this method and use of the mouse
    Publication number: 20030182671
    Abstract: The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor &ggr;-chain gene-knockout mouse with the thus backcrossed mouse. It is usable for producing a human antibody and establishing a stem cell assay system, a tumor model and a virus-infection model.
    Type: Application
    Filed: September 10, 2002
    Publication date: September 25, 2003
    Inventors: Mamoru Ito, Kimio Kobayashi, Tatsutoshi Nakahata, Koichiro Tsuji, Sonoko Habu, Yoshio Koyanagi, Naoki Yamamoto, Kazuo Sugamura, Kiyoshi Ando, Tatsuji Nomura
  • Method for examining neurovirulence of polio virus
    Patent number: 5986171
    Abstract: The present invention relates to a method of examining the neurovirulence of a polio virus, which comprises inoculating a polio virus into the spinal cord of a transgenic mouse comprising a gene for a polio virus receptor.
    Type: Grant
    Filed: November 15, 1995
    Date of Patent: November 16, 1999
    Assignees: Japan Poliomyelitis Research Institute, Central Institute for Experimental Animals
    Inventors: Shinobu Abe, Yoshihiro Ota, So Hashizume, Satoshi Koike, Akio Nomoto, Hiromichi Yonekawa, Choji Taya, Tatsuji Nomura