Patents by Inventor Tatsuji Seki

Tatsuji Seki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PLANT CELLS AND PLANTS EXPRESSING FUCOSYL TRANSFERASE FOR ANIMAL-TYPE SUGAR CHAIN ADDING FUNCTION
    Publication number: 20170275599
    Abstract: A plant cell having an animal-type sugar chain adding function is provided. The plant cell has an introduced gene encoding an enzyme derived from an animal, and the enzyme can transfer a fucose residue to a reducing terminal acetylglucosamine residue of a sugar chain of a glycoprotein.
    Type: Application
    Filed: November 21, 2016
    Publication date: September 28, 2017
    Applicant: Phyton Holdings, LLC
    Inventors: Kazuhito Fujiyama, Tatsuji Seki, Naoyuki Taniguchi
  • Method of co-expressing galactosyltransferase and a glycoprotein in a transgenic plant cell and sialylating the glycoprotein for production of glycoprotein having human-type sugar chain
    Patent number: 9574218
    Abstract: A method for the secretory production of a glycoprotein having a human-type sugar chain, comprising a step of introducing a gene of an enzyme capable of performing a transfer reaction of a galactose residue to a non-reducing terminal acetylglucosamine residue, and a gene of heterologous glycoprotein, to obtain a transformed plant cell, a step of culturing the plant cell, and a step of recovering the culture medium of the plant cell. The method further includes isolating the glycoprotein from the culture medium and contacting the isolated glycoprotein with a sialic acid transferase to add a sialic acid residue attached to the galactose residue in the N-glycan.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: February 21, 2017
    Assignee: Phyton Holdings, LLC
    Inventors: Kazuhito Fujiyama, Tatsuji Seki, Toshiomi Yoshida
  • METHOD FOR SECRETORY PRODUCTION OF GLYCOPROTEIN HAVING HUMAN-TYPE SUGAR CHAIN USING PLANT CELL
    Publication number: 20140377799
    Abstract: A method for the secretory production of a glycoprotein having a human-type sugar chain, comprising a step of introducing a gene of an enzyme capable of performing a transfer reaction of a galactose residue to a non-reducing terminal acetylglucosamine residue, and a gene of heterologous glycoprotein, to obtain a transformed plant cell, a step of culturing the plant cell, and a step of recovering the culture medium of the plant cell.
    Type: Application
    Filed: April 14, 2014
    Publication date: December 25, 2014
    Applicant: Phyton Holdings, LLC
    Inventors: Kazuhito Fujiyama, Tatsuji Seki, Toshiomi Yoshida
  • Plant-produced glycoprotein comprising human-type sugar chain
    Patent number: 8853370
    Abstract: The present invention provides a method for manufacturing a glycoprotein having a human-type sugar chain comprising a step in which transformed plant cell is obtained by introducing to a plant cell the gene of glycosyltransfetase and the gene of an exogenous glycoprotein, and a step in which the obtained transformed plant cell is cultivated.
    Type: Grant
    Filed: July 11, 2012
    Date of Patent: October 7, 2014
    Assignee: Phyton Holdings, LLC
    Inventors: Tatsuji Seki, Kazuhito Fujiyama
  • Method of expressing galactosyltransferase and inhibiting xylosyltransferase or fucosyltransferase in a transgenic plant cell for secretory production of glycoproteins having human-type sugar chains
    Patent number: 8735656
    Abstract: A method for the secretory production of a glycoprotein having a human-type sugar chain, comprising a step of introducing a gene of an enzyme capable of performing a transfer reaction of a galactose residue to a non-reducing terminal acetylglucosamine residue, and a gene of heterologous glycoprotein, to obtain a transformed plant cell, a step of culturing the plant cell, and a step of recovering the culture medium of the plant cell.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: May 27, 2014
    Assignee: Phyton Holdings, LLC
    Inventors: Kazuhito Fujiyama, Tatsuji Seki
  • METHOD FOR SECRETORY PRODUCTION OF GLYCOPROTEIN HAVING HUMAN-TYPE SUGAR CHAIN USING PLANT CELL
    Publication number: 20130164782
    Abstract: A method for the secretory production of a glycoprotein having a human-type sugar chain, comprising a step of introducing a gene of an enzyme capable of performing a transfer reaction of a galactose residue to a non-reducing terminal acetylglucosamine residue, and a gene of heterologous glycoprotein, to obtain a transformed plant cell, a step of culturing the plant cell, and a step of recovering the culture medium of the plant cell.
    Type: Application
    Filed: September 14, 2012
    Publication date: June 27, 2013
    Applicant: Phyton Holdings, LLC
    Inventors: Kazuhito FUJIYAMA, Tatsuji Seki
  • METHOD FOR MANUFACTURING GLYCOPROTEINS HAVING HUMAN-TYPE GLYCOSYLATION
    Publication number: 20130040391
    Abstract: The present invention provides a method for manufacturing a glycoprotein having a human-type sugar chain comprising a step in which transformed plant cell is obtained by introducing to a plant cell the gene of glycosyltransfetase and the gene of an exogenous glycoprotein, and a step in which the obtained transformed plant cell is cultivated.
    Type: Application
    Filed: July 11, 2012
    Publication date: February 14, 2013
    Applicant: Phyton Holdings, LLC.
    Inventors: Tatsuji SEKI, Kazuhito Fujiyama
  • Method for secretory production of glycoprotein having human-type sugar chain using plant cell
    Patent number: 8309795
    Abstract: A method for the secretory production of a glycoprotein having a human-type sugar chain, comprising a step of introducing a gene of an enzyme capable of performing a transfer reaction of a galactose residue to a non-reducing terminal acetylglucosamine residue, and a gene of heterologous glycoprotein, to obtain a transformed plant cell, a step of culturing the plant cell, and a step of recovering the culture medium of the plant cell.
    Type: Grant
    Filed: July 15, 2010
    Date of Patent: November 13, 2012
    Assignee: Phyton Holdings, LLC
    Inventors: Kazuhito Fujiyama, Tatsuji Seki
  • Method for manufacturing glycoproteins having human-type glycosylation
    Patent number: 8241909
    Abstract: The present invention provides a method for manufacturing a glycoprotein having a human-type sugar chain comprising a step in which transformed plant cell is obtained by introducing to a plant cell the gene of glycosyltransfetase and the gene of an exogenous glycoprotein, and a step in which the obtained transformed plant cell is cultivated.
    Type: Grant
    Filed: June 7, 2010
    Date of Patent: August 14, 2012
    Assignee: Phyton Holdings, LLC
    Inventors: Tatsuji Seki, Kazuhito Fujiyama
  • Method For Secretory Production of Glycoprotein Having Human-Type Sugar Chain Using Plant Cell
    Publication number: 20120060239
    Abstract: A method for the secretory production of a glycoprotein having a human-type sugar chain, comprising a step of introducing a gene of an enzyme capable of performing a transfer reaction of a galactose residue to a non-reducing terminal acetylglucosamine residue, and a gene of heterologous glycoprotein, to obtain a transformed plant cell, a step of culturing the plant cell, and a step of recovering the culture medium of the plant cell.
    Type: Application
    Filed: July 15, 2010
    Publication date: March 8, 2012
    Inventors: Kazuhito Fujiyama, Tatsuji Seki
  • METHOD FOR MANUFACTURING GLYCOPROTEINS HAVING HUMAN-TYPE GLYCOSYLATION
    Publication number: 20110070649
    Abstract: The present invention provides a method for manufacturing a glycoprotein having a human-type sugar chain comprising a step in which transformed plant cell is obtained by introducing to a plant cell the gene of glycosyltransfetase and the gene of an exogenous glycoprotein, and a step in which the obtained transformed plant cell is cultivated.
    Type: Application
    Filed: June 7, 2010
    Publication date: March 24, 2011
    Inventors: Tatsuji Seki, Kazuhito Fujiyama
  • Method for manufacturing glycoproteins having human-type glycosylation
    Patent number: 7388081
    Abstract: The present invention provides a method for manufacturing a glycoprotein having a human-type sugar chain comprising a step in which transformed plant cell is obtained by introducing to a plant cell the gene of glycosyltransfetase and the gene of an exogenous glycoprotein, and a step in which the obtained transformed plant cell is cultivated.
    Type: Grant
    Filed: June 17, 2004
    Date of Patent: June 17, 2008
    Assignee: DFB Biotech, Inc.
    Inventors: Tatsuji Seki, Kazuhito Fujiyama
  • Method for manufacturing glycoproteins having human-type glycosylation
    Publication number: 20080124798
    Abstract: The present invention provides a method for manufacturing a glycoprotein having a human-type sugar chain comprising a step in which transformed plant cell is obtained by introducing to a plant cell the gene of glycosyltransferase and the gene of an exogenous glycoprotein, and a step in which the obtained transformed plant cell is cultivated.
    Type: Application
    Filed: June 6, 2007
    Publication date: May 29, 2008
    Applicant: DFB Biotech, Inc.
    Inventors: Tatsuji Seki, Kazuhito Fujiyama
  • Method for secretory production of glycoprotein having human-type sugar chain using plant cell
    Publication number: 20080034456
    Abstract: A method for the secretory production of a glycoprotein having a human-type sugar chain, comprising a step of introducing a gene of an enzyme capable of performing a transfer reaction of a galactose residue to a non-reducing terminal acetylglucosamine residue, and a gene of heterologous glycoprotein, to obtain a transformed plant cell, a step of culturing the plant cell, and a step of recovering the culture medium of the plant cell.
    Type: Application
    Filed: March 14, 2007
    Publication date: February 7, 2008
    Inventors: Kazuhito Fujiyama, Tatsuji Seki
  • Plant cell having animal-type sugar chain adding function
    Publication number: 20070214519
    Abstract: A plant cell having an animal-type sugar chain adding function is provided. The plant cell has an introduced gene encoding an enzyme derived from an animal, and the enzyme can transfer a fucose residue to a reducing terminal acetylglucosamine residue of a sugar chain of a glycoprotein.
    Type: Application
    Filed: January 4, 2007
    Publication date: September 13, 2007
    Inventors: Kazuhito Fujiyama, Tatsuji Seki, Naoyuki Taniguchi
  • Method for manufacturing glycoproteins having human-type glycosylation
    Patent number: 6998267
    Abstract: The present invention provides a method for manufacturing a glycoprotein having a mammalian-type or human-type sugar chain comprising a step in which a transformed plant cell is obtained by introducing to a plant cell a gene encoding a glycosyltransferase enzyme and a gene encoding an exogenous glycoprotein, and a step in which the obtained transformed plant cell is cultivated.
    Type: Grant
    Filed: December 8, 1999
    Date of Patent: February 14, 2006
    Assignee: The Dow Chemical Company
    Inventors: Tatsuji Seki, Kazuhito Fujiyama
  • Plant cell having animal-type sugar chain adding function
    Publication number: 20050144670
    Abstract: A plant cell having an animal-type sugar chain adding function is provided. The plant cell has an introduced gene encoding an enzyme derived from an animal, and the enzyme can transfer a fucose residue to a reducing terminal acetylglucosamine residue of a sugar chan of a glycoprotein.
    Type: Application
    Filed: March 6, 2002
    Publication date: June 30, 2005
    Inventors: Kazuhito Fujiyama, Tatsuji Seki, Naoyuki Taniguchi
  • Method for manufacturing glycoproteins having human-type glycosylation
    Publication number: 20050143564
    Abstract: The present invention provides a method for manufacturing a glycoprotein having a human-type sugar chain comprising a step in which transformed plant cell is obtained by introducing to a plant cell the gene of glycosyltransfetase and the gene of an exogenous glycoprotein, and a step in which the obtained transformed plant cell is cultivated.
    Type: Application
    Filed: June 17, 2004
    Publication date: June 30, 2005
    Inventors: Tatsuji Seki, Kazuhito Fujiyama
  • Fused protein having beta 1,2-n-acetylglucosaminyltransferase II activity and process for producing the same
    Publication number: 20040110176
    Abstract: To provide a fusion protein of a sugar-bonding protein and &bgr;1,2-N-acetylglucosaminyltransferase II, and a method for producing such proteins in E. coli cells.
    Type: Application
    Filed: November 12, 2003
    Publication date: June 10, 2004
    Inventors: Kazuhito Fujiyama, Tatsuji Seki, Shin-Ichiro Nishimura, Hiroaki Nakagawa, Susumu Nishiguchi