Abstract: A compound having a high tumor accumulation rate, or a salt thereof, and a contrast agent for optical imaging are provided. A compound having at least one specific organic dye covalently bound to polyethylene glycol, or a salt thereof is provided.

Abstract: An object is to provide a polymer having a high tumor/blood ratio. The present invention provides a polymer represented by the following formula (P1): wherein in the formula (P1), R represents any of a residue derived from a polymerization initiator, or a functional group; A may not be present, and when present, A represents any of a low-molecular compound, a dye, a reporter molecule, a target-binding molecule, a polymer or D; L represents a linker and L may not be present; n1 represents an integer of 1 or more; and D represents a dye backbone of a dye having absorption in the near-infrared region.

Abstract: A fuel supply device includes a cover member attached to an opening of a fuel tank, a pump unit including a pump, and a connecting portion which connects the cover member and the pump unit. The pump unit is connected so as to be relatively movable with respect to the connecting portion when a connecting shaft which is formed as part of one of the connecting portion or the pump unit, is inserted into the connecting hole formed as part of the other of the two. The connecting hole has an elongated hole portion that allows the connecting shaft to move in the upward and downward directions, and allows the pump unit to be relatively movable with respect to the connecting portion. The pump unit includes an engagement portion abutting a lower terminal end of the connecting portion when the fuel supply device is attached to the fuel tank.

Abstract: A fuel supply device has a cover member which is attached to an opening of a fuel tank, a pump unit comprising a pump, and a connecting portion configured to connect the cover member and the pump unit. A connecting shaft which is formed to one of the two connected members of the connecting portion is inserted into a connecting hole which is formed to the other of the two such that the pump unit is connected to be relatively movable to the connecting portion. The pump unit includes an upper base on which the pump is placed, and a lower base which contacts to the fuel tank. The upper base and the lower base are coupled through attachments whereby an engagement portion of the upper base is fitted into a recessed portion formed on the side of the lower base. The recessed portion has a pair of planes opposing to each other and oriented toward a bottom surface of the lower base from a predetermined position.

Abstract: A photoacoustic apparatus is used that has: a detecting unit that detects photoacoustic waves generated by an object containing contrast agent in first blood vessels of circulating blood and in second blood vessels; and a signal processing unit that generates contrast agent distribution and acquires contrast agent concentration change in the circulating blood. The signal processing unit acquires the position of the first blood vessels on the basis of a time-series change of the contrast agent distribution and the contrast agent concentration change, and lowers the concentration at the position of the first blood vessels on the basis of the contrast agent distribution.

Abstract: A fuel supply device has a cover member which is attached to an opening portion of a fuel tank and a pump unit comprising a pump. The cover member and pump unit are connected via a connecting portion where the pump unit is rotatably connected to the connecting portion. Further, the fuel supply device includes a fuel residual amount detection device which is attached to the pump unit and configured to detect the residual amount of fuel. The fuel residual amount detection device includes a gauge main body to which electric wirings are connected, an arm portion which is movably mounted relative to the gauge main body and a float which is attached to a leading end of the arm portion. The float is positioned above a lower terminal end of the base portion when the cover portion is held and lifted while the pump unit rotates with respect to the connecting portion.

Abstract: To provide a compound having high TB and a contrast agent for optical imaging. The compound has a molecular weight of a specific range, the compound in which two polyethylene glycols are bonded to a specific cyanine pigment through a linker. The present invention provides a compound which has a high T/B and which can be used as a contrast agent capable of imaging a tumor portion with high contrast.

Abstract: A fuel supply device includes a cover member which is attached to an opening of a fuel tank, a pump unit comprising a pump, and a connecting portion for connecting the cover member and the pump unit. The pump unit is connected to the connecting portion so as to be relatively movable to the cover member. When the fuel supply device is attached to the fuel tank, an engagement portion provided at a lower portion of the pump unit abuts the connecting portion such that via the engagement portion the connecting portion presses the pump unit against the fuel tank.

Abstract: A photoacoustic apparatus, comprises a light source that irradiates an object with light; a plurality of acoustic wave detectors that receive acoustic waves generated from the object, convert the acoustic waves into an electrical signal, and output the electrical signal; and an information acquisition unit that acquires information of the object, based on the electrical signals, wherein the information acquisition unit acquires, for each of the acoustic wave detectors, a change in the intensity of the electrical signal, after the object that has been injected with a contrast agent is irradiated with light that decomposes the contrast agent, and acquires information relating to blood flow, based on the change in the intensity of the electrical signal.

Abstract: A fuel supply device includes a fuel pump for delivering fuel within the fuel tank to the outside and a sub-tank having a temporary storage region capable of temporarily storing the fuel. The sub-tank includes an inflow opening to allow the fuel to flow into the sub-tank under its own weight. The temporary storage region includes a top part positioned above the inflow opening.

Abstract: A fuel filter device includes a bag-shaped filter member filtering fuel that is drawn into a fuel pump, an inner frame member retaining the filter member in an expanded state, and a mounting member connected to the inner frame member and serving to communicate an internal space of the filter member with an outside. A valve chamber is defined by the inner frame member and the mounting member, and a check valve serving to prevent backflow of fuel is disposed in the valve chamber. The check valve includes a flat-plate shaped valve body having elasticity. The check valve opens against its weight when the fuel pump is operated, and the check valve closes due to its weight when the operation of the fuel pump is stopped.

Abstract: A fuel supply device includes a cover member attached to an opening of a fuel tank, a pump unit including a pump, and a connecting portion which connects the cover member and the pump unit. The pump unit is connected so as to be relatively movable with respect to the connecting portion when a connecting shaft which is formed as part of one of the connecting portion or the pump unit, is inserted into the connecting hole formed as part of the other of the two. The connecting hole has an elongated hole portion that allows the connecting shaft to move in the upward and downward directions, and allows the pump unit to be relatively movable with respect to the connecting portion. The pump unit includes an engagement portion abutting a lower terminal end of the connecting portion when the fuel supply device is attached to the fuel tank.

Abstract: A fuel supply device has a cover member which is attached to an opening of a fuel tank, a pump unit comprising a pump, and a connecting portion configured to connect the cover member and the pump unit. A connecting shaft which is formed to one of the two connected members of the connecting portion is inserted into a connecting hole which is formed to the other of the two such that the pump unit is connected to be relatively movable to the connecting portion. The pump unit includes an upper base on which the pump is placed, and a lower base which contacts to the fuel tank. The upper base and the lower base are coupled through attachments whereby an engagement portion of the upper base is fitted into a recessed portion formed on the side of the lower base. The recessed portion has a pair of planes opposing to each other and oriented toward a bottom surface of the lower base from a predetermined position.

Abstract: A fuel supply device has a cover member which is attached to an opening of a fuel tank, a pump unit provided with a pump, and a connecting portion for connecting the cover member and the pump unit. The fuel supply device has a connecting shaft which is formed on either one of the connecting portion or the pump unit, and a connecting hole which is formed on the other. The fuel supply device has a guide mechanism which can guide the pump unit. The guide mechanism includes a first guide portion formed at the connecting portion and a second guide portion formed at the pump unit. One of the first guide portion or the second guide portion includes a protruding portion which protrudes in a position spaced apart from the connecting shaft. The other guide portion is formed to restrict a movable range of the protruding portion.

Abstract: A fuel supply device includes a cover, a base including a base main body, and a connecting portion configured to connect the cover and the base. The base main body and the connecting portion are connected by a connecting shaft comprising a shaft portion and a bulge portion, a connecting hole formed so as to continuously extend an engagement region and an insertion region, and a stopper piece capable of limiting a movable range of the shaft portion located within the engagement region towards the insertion region. A guide mechanism is provided for guiding the connecting shaft to move so that at least one part of the stopper piece is positioned between the bulge portion and the base portion when a predetermined amount of force is applied to the connecting shaft.

Abstract: A compound having a high tumor accumulation rate, or a salt thereof, and a contrast agent for optical imaging are provided. A compound having at least one specific organic dye covalently bound to polyethylene glycol, or a salt thereof is provided.

Abstract: There is provided an ICG-loaded polymer nanoparticle that is dynamically stable, prevents the leakage of contained ICG and the resulting discoloration, and has a high molar absorbance coefficient. The particle contains a hydrophilic dye having a sulfonate group and a hydrophobic polymer, and the particle further contains at least one of a lipid having a positively charged region, a nicotinic acid derivative and a thiamine derivative.

Abstract: The present invention provides a compound which exhibits a high degree of accumulation into a tumor even when some extent of time has passed after performing administration and which facilitates an increase in the intensity of photoacoustic signal produced by the tumor. A compound produced by bonding of a polyethylene glycol and a specific cyanine based compound.

Abstract: A compound or a salt thereof in which polyethylene glycol is bonded to a specific cyanine dye.

Abstract: A photoacoustic device comprises a light source configured to generate first and second lights; an irradiation unit configured to generate a first acoustic wave from an object including a contrast agent by irradiating the object with the first light, and then bleach the contrast agent by irradiating the object with the second light and generate a second acoustic wave from the object by irradiating the object with the first light after bleaching; a receiving unit configured to output a first signal upon receiving the first acoustic wave and output a second signal upon receiving the second acoustic wave; and an acquisition unit configured to acquire first information based on the first signal, and acquire second information based on the second signal.