Abstract: Provided are a program and the like in which a cleaning efficiency can be improved. A program allows a computer to execute processing of: acquiring an image including a still image or a moving image that is obtained by imaging an inside of a medical facility with an imaging device provided in the medical facility, or operation content information relevant to operation content in the medical facility; specifying a part to be cleaned in the medical facility and a cleaning method, on the basis of the acquired image or the acquired operation content information; and outputting a cleaning command according to the specified part to be cleaned in the medical facility and the specified cleaning method.

Abstract: A flow path device comprises a flow path 50 that includes a plurality of inlet portion side first flow paths 61 connected to an inlet portion 30; a plurality of inlet portion side second flow paths 62 connected to the plurality of respective inlet portion side first flow paths 61; and a plurality of reaction chamber portions 63 connected to the plurality of respective inlet portion side second flow paths 62, wherein the plurality of inlet portion side first flow paths 61 are configured such that when a positive pressure is applied to a liquid in the plurality of inlet portion side first flow paths 61, the amounts of the liquid flowing out from the plurality of inlet portion side first flow paths 61 to the respective reaction chamber portions 63 are substantially the same, wherein plurality of inlet portion side second flow paths 62 are configured such that when the magnitude of the positive pressure applied to the liquid in the plurality of inlet portion side first flow paths 61 is less than a threshold value

Abstract: A flow path device 20 is a biological component test flow path device for storing a specimen used to test a biological component in a specimen separated from a living body and includes: a main body portion 30; at least one or more flow paths 40 which are provided inside the main body portion 30 so that at least one or more inlet open ends 41 and at least one or more outlet open ends 42 in a plurality of different open ends of the at least one or more flow paths 40 overlap each other or are adjacent to each other and are exposed to the outside of the main body portion 30; and a lid portion 50 which opens and closes at least one or more inlet open ends 41 and at least one or more outlet open ends 42 together.

Abstract: A method of measuring a target substance contained in a sample may include passing a complex formed by allowing the target substance to react with a predetermined carrier through a pore provided in a substrate. A size of the complex may be measured based on change in electrical characteristics occurring when the complex is passed through the pore in the pass-through step. The number of molecules of target substance may be determined based on the size of the complex measured in the measuring step.

Abstract: The present invention provides a method for adequately analyzing a target DNA after genomic DNA cleavage reaction with a restriction enzyme. More specifically, the present invention provides a method for measuring a target DNA, including (1) cleaving a genomic DNA with a restriction enzyme in a solution to obtain a mixed solution containing (a) completely cleaved DNA fragments consisting of the target DNA, (b) incompletely cleaved DNA fragments comprising the target DNA, and (c) DNA fragments not comprising the target DNA; (2) removing the DNA fragments of (b) from said mixed solution to obtain a solution containing the DNA fragment of (a) and the DNA fragments of (c); and (3) analyzing the target DNA in the solution obtained in (2).

Abstract: The present invention provides a method for measuring a modified nucleobase that increases detection sensitivity for the modified nucleobase in a target nucleic acid. Specifically, the present invention provides a method for measuring a modified nucleobase including: (1) incubating a nucleic acid sample, a capture probe, and a guide probe in a solution; and (2) measuring the modified nucleobase using an antibody against the modified nucleobase in the solution obtained at (1). The present invention also provides a kit for measuring a modified nucleobase including: (I) a guide probe; and (II) a capture probe and/or an antibody against the modified nucleobase.

Abstract: The present invention provides a technique that suppresses a background value of a detection signal to construct an immunoassay system that detects a modified nucleobase. Specifically, the present invention provides a method for measuring a modified nucleobase including incubating a nucleic acid sample, a capture probe, and a solid phase probe in a solution and measuring a modified nucleobase using an antibody against the modified nucleobase in the obtained solution. The present invention also provides a kit for measuring a modified nucleobase including a capture probe, a solid phase probe, and an antibody against a modified nucleobase.

Abstract: The present invention provides a method and means that can specifically detect a target nucleic acid containing a modified nucleobase. Specifically, the present invention provides a method for measuring a target nucleic acid containing a modified nucleobase, the method comprising: (1) incubating a nucleic acid sample and a heterologous nucleic acid probe having a property of pairing with a modified nucleobase, in a solution; and (2) measuring the modified nucleobase using an antibody against a modified nucleobase having a property of heterologous pairing, in the solution obtained at (1). The present invention also provides a kit for measuring a target nucleic acid containing a modified nucleobase, the kit comprising: (I) a heterologous nucleic acid probe having a property of pairing with a modified nucleobase; and (II) an antibody against a modified nucleobase having a property of heterologous pairing.

Abstract: The present invention provides a method for measuring a modified nucleobase that increases detection sensitivity for the modified nucleobase in a target nucleic acid. Specifically, the present invention provides a method for measuring a modified nucleobase including: (1) incubating a nucleic acid sample, a capture probe, and a guide probe in a solution; and (2) measuring the modified nucleobase using an antibody against the modified nucleobase in the solution obtained at (1). The present invention also provides a kit for measuring a modified nucleobase including: (I) a guide probe; and (II) a capture probe and/or an antibody against the modified nucleobase.

Abstract: The present invention provides a technique that suppresses a background value of a detection signal to construct an immunoassay system that detects a modified nucleobase. Specifically, the present invention provides a method for measuring a modified nucleobase including incubating a nucleic acid sample, a capture probe, and a solid phase probe in a solution and measuring a modified nucleobase using an antibody against the modified nucleobase in the obtained solution. The present invention also provides a kit for measuring a modified nucleobase including a capture probe, a solid phase probe, and an antibody against a modified nucleobase.

Abstract: An object of the present invention is to provide a technique that suppresses a background value of a detection signal to construct an immunoassay system for detecting a modified nucleobase. Specifically, the present invention provides a method for measuring a modified nucleobase including incubating a nucleic acid sample and a capture probe in a solution and measuring a modified nucleobase using an antibody against the modified nucleobase in the presence of an absorbent polynucleotide in the obtained solution. The present invention also provides a kit for measuring a modified nucleobase including a capture probe, an absorbent polynucleotide, and an antibody against a modified nucleobase.

Abstract: The present invention provides a technique that suppresses a background value of a detection signal to construct an immunoassay system that detects a modified nucleobase. Specifically, the present invention provides a method for measuring a modified nucleobase comprising incubating a nucleic acid sample (e.g., a sample containing a target DNA containing the modified nucleobase) and a heterogeneous nucleic acid probe (e.g., an RNA probe) in a solution and measuring the modified nucleobase using an antibody against the modified nucleobase in the obtained solution. The present invention also provides a kit for measuring a modified nucleobase comprising a heterogeneous nucleic acid probe and an antibody against the modified nucleobase.

Abstract: The present invention provides a detection system using a nucleic acid probe which is commonly used in a measurement system using a recombinase (e.g., nucleic acid amplification reaction). Specifically, the present invention provides a method for detecting a target nucleic acid, comprising measuring the target nucleic acid using a cleavage enzyme, a recombinase, and a probe having characteristics of the following (a) to (c): (a) being a single-stranded nucleic acid molecule comprising a pair of regions capable of complementarily binding to each other, and a region capable of complementarily binding to the target nucleic acid; (b) comprising a site to be cleaved by the cleavage enzyme; and (c) having a terminal label.

Abstract: The present invention provides a method for stably correcting a detection signal in an isothermal nucleic acid amplification reaction, particularly an isothermal nucleic acid amplification reaction performed at low temperature. Specifically, the present invention provides a method for detecting a target nucleic acid in an isothermal nucleic acid amplification reaction, comprising the following (1) and (2): (1) subjecting a nucleic acid sample to an amplification reaction of a target nucleic acid under an isothermal condition in the presence of a nucleic acid probe for correction and a nucleic acid probe for detection of the target nucleic acid; and (2) correcting a detection signal due to the nucleic acid probe for detection with a detection signal due to the nucleic acid probe for correction in the amplification reaction.

Abstract: The present invention provides a chemiluminescence enhancer treated to retain favorable dispersibility of fine solid carriers and stably exert a chemiluminescence enhancing action. The invention provides a chemiluminescence enhancer used for signal detection in a solid phase immunoassay using antigen or/and antibody immobilized onto fine solid carriers dispersible in a liquid medium, consisting of a water soluble macromolecular quaternary ammonium salt, a quaternary sulfonium salt or a quaternary phosphonium salt in order to enhance emission of light caused by an enzymatic reaction of a chemiluminescent substrate having dioxetane, wherein the chemiluminescence enhancer is given an aggregation inhibition treatment of the fine solid carriers by the treatment with an oxidizing agent or a reducing agent, and a chemiluminescence method and a kit using the chemiluminescence enhancer.

Abstract: The present invention provides a chemiluminescence enhancer treated to retain favorable dispersibility of fine solid carriers and stably exert a chemiluminescence enhancing action. The invention provides a chemiluminescence enhancer used for signal detection in a solid phase immunoassay using antigen or/and antibody immobilized onto fine solid carriers dispersible in a liquid medium, consisting of a water soluble macromolecular quaternary ammonium salt, a quaternary sulfonium salt or a quaternary phosphonium salt in order to enhance emission of light caused by an enzymatic reaction of a chemiluminescent substrate having dioxetane, wherein the chemiluminescence enhancer is given an aggregation inhibition treatment of the fine solid carriers by the treatment with an oxidizing agent or a reducing agent, and a chemiluminescence method and a kit using the chemiluminescence enhancer.

Abstract: The present invention provides a chemiluminescence enhancer treated to retain favorable dispersibility of fine solid carriers and stably exert a chemiluminescence enhancing action. The invention provides a chemiluminescence enhancer used for signal detection in a solid phase immunoassay using antigen or/and antibody immobilized onto fine solid carriers dispersible in a liquid medium, consisting of a water soluble macromolecular quaternary ammonium salt, a quaternary sulfonium salt or a quaternary phosphonium salt in order to enhance emission of light caused by an enzymatic reaction of a chemiluminescent substrate having dioxetane, wherein the chemiluminescence enhancer is given an aggregation inhibition treatment of the fine solid carriers by the treatment with an oxidizing agent or a reducing agent, and a chemiluminescence method and a kit using the chemiluminescence enhancer.

Abstract: A method for measuring chemiluminescence by which measurement of chemiluminescence can be carried out efficiently and accurately. In this method, an enzyme reaction of a chemiluminescent substrate in the presence of the enzyme carrying out the enzyme reaction and a chemiluminescence enhancer is conducted further in the presence of a chemiluminescence intensity-adjusting agent; and then the resulting chemiluminescence from the reaction product is measured.

Abstract: A method for measuring chemiluminescence by which measurement of chemiluminescence can be carried out efficiently and accurately. In this method, an enzyme reaction of a chemiluminescent substrate in the presence of the enzyme carrying out the enzyme reaction and a chemiluminescence enhancer is conducted further in the presence of a chemiluminescence intensity-adjusting agent; and then the resulting chemiluminescence from the reaction product is measured.