Patents by Inventor Tatsuo Ichihara
Tatsuo Ichihara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240137655Abstract: An illumination apparatus is communicatively connected to an image pickup apparatus and configured to emit illumination light. The illumination apparatus performs light emission control of the illumination light under the custom light emitting condition by reading the custom light emitting condition corresponding to a custom imaging condition from the memory in a case where imaging under the custom imaging condition set by the user is selected in the image pickup apparatus.Type: ApplicationFiled: October 16, 2023Publication date: April 25, 2024Inventors: Yoshiro ICHIHARA, Tatsuo TAKATORI
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Patent number: 7867708Abstract: To solve a problem occurring in the PALSAR method that a polymer would be formed in the state of unbound to a captured test gene and thus affect the quantitative characteristics as a nonspecific signal, it is intended to develop a technique whereby the polymer formation is controlled in the step of forming an assembly (polymer) of probes so that the polymer is formed exclusively on a test gene to thereby improve the sensitivity and quantitative characteristics. It is found that the polymer can be quantitatively formed and a nonspecific reaction can be inhibited by, in the step of forming a polymer by reacting plural kinds of probes having abilities to complementarily bind to each other, not adding or reacting these probes at once but starting with the reaction of a first probe in one group, and then reacting the second probe in the other group followed by the reactions of probes one by one (i.e., the first probe, the second probe, and so on).Type: GrantFiled: September 8, 2005Date of Patent: January 11, 2011Assignee: Eisai R&D Management Co., Ltd.Inventors: Tatsuo Ichihara, Mitsugu Usui
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Publication number: 20080199968Abstract: To solve a problem occurring in the PALSAR method that a polymer would be formed in the state of unbound to a captured test gene and thus affect the quantitative characteristics as a nonspecific signal, it is intended to develop a technique whereby the polymer formation is controlled in the step of forming an assembly (polymer) of probes so that the polymer is formed exclusively on a test gene to thereby improve the sensitivity and quantitative characteristics. It is found that the polymer can be quantitatively formed and a nonspecific reaction can be inhibited by, in the step of forming a polymer by reacting plural kinds of probes having abilities to complementarily bind to each other, not adding or reacting these probes at once but starting with the reaction of a first probe in one group, and then reacting the second probe in the other group followed by the reactions of probes one by one (i.e., the first probe, the second probe, and so on).Type: ApplicationFiled: September 8, 2005Publication date: August 21, 2008Applicant: EISAI CO., LTD.Inventors: Tatsuo Ichihara, Mitsugu Usui
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Patent number: 7105299Abstract: A kit comprising an oligonucleotide-immobilized substrate obtained by immobilizing, on a substrate, one or more kinds of oligonucleotides that enable detection of a polymorphism in a nucleotide sequence of mitochondrial DNA control region of chum salmon, of which standard is represented by the nucleotide sequence of SEQ ID NO: 8, at a position selected from the 10th, 30th, 42nd, 57th, 70th, 96th, 108th, 154th, 194th, 231st, 242nd, 250th, 260th, 339th, 340th, 386th, 395th, 401st and 471st positions is used to detect the polymorphism based on hybridization of the oligonucleotides with a nucleic acid derived from specimen chum salmon and thereby determine a haplotype of the specimen chum salmon.Type: GrantFiled: December 12, 2002Date of Patent: September 12, 2006Assignee: Nisshinbo Industries, Inc.Inventors: Shogo Moriya, Tatsuo Ichihara, Osamu Suzuki, Akihisa Urano, Syuiti Abe
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Patent number: 7037649Abstract: A nucleic acid to be immobilized and used for hybridization of nucleic acids using an immobilized nucleic acid, which has a polymer comprising a compound having an unsaturated bond, said polymer being bonded to the 3? end or 5? end or both ends of the nucleic acid; a nucleic acid-immobilized substrate comprising a substrate for immobilizing a nucleic acid and the polymer-having nucleic acid immobilized on the substrate; and a method for detecting a nucleic acid by hybridization using an immobilized nucleic acid, which comprises using the nucleic acid-immobilized substrate.Type: GrantFiled: January 26, 2001Date of Patent: May 2, 2006Assignee: Nisshinbo Industries, Inc.Inventors: Naoki Kimura, Tatsuo Ichihara, Shogo Moriya
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Publication number: 20030228585Abstract: HLA genotype of a test specimen is determined by hybridization of a nucleic acid sequence derived from the test specimen by using a substrate on which oligonucleotides of 10-24 nucleotide length derived from sequences of a group of genes belonging to HLA class I or class II antigen on a human genome and including polymorphism of gene as alloantigens in the sequences are immobilized through covalent bonds. There are provided a typing kit and typing method that are suitable for processing of a large number of specimens and enable high accuracy typing by one test.Type: ApplicationFiled: November 27, 2002Publication date: December 11, 2003Inventors: Hidetoshi Inoko, Taeko Kagiya, Tatsuo Ichihara, Yoshiyuki Matsumura, Shogo Moriya, Michio Nishida
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Patent number: 6656682Abstract: A nucleic acid-immobilized substrate which comprises a carrier comprising a base material and a compound having a carbodiimide group or an isocyanate group carried by the base material, and the same kind or different kinds of nucleic acids immobilized in the form of dots through the carbodiimide group or the isocyanate group at a plurality of sites on the carrier.Type: GrantFiled: June 20, 2000Date of Patent: December 2, 2003Assignee: Nisshinbo Industries, Inc.Inventors: Osamu Suzuki, Tatsuo Ichihara, Namiko Shiohata, Yoshiyuki Matsumura
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Publication number: 20030124608Abstract: A kit comprising an oligonucleotide-immobilized substrate obtained by immobilizing, on a substrate, one or more kinds of oligonucleotides that enable detection of a polymorphism in a nucleotide sequence of mitochondrial DNA control region of chum salmon, of which standard is represented by the nucleotide sequence of SEQ ID NO: 8, at a position selected from the 10th, 30th, 42nd, 57th, 70th, 96th, 108th, 154th, 194th, 231st, 242nd, 250th, 260th, 339th, 340th, 386th, 395th, 401st and 471st positions is used to detect the polymorphism based on hybridization of the oligonucleotides with a nucleic acid derived from specimen chum salmon and thereby determine a haplotype of the specimen chum salmon.Type: ApplicationFiled: December 12, 2002Publication date: July 3, 2003Inventors: Shogo Moriya, Tatsuo Ichihara, Osamu Suzuki, Akihisa Urano, Syuiti Abe
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Publication number: 20030096289Abstract: Presence or absence of methylation of C located on 5′ side of G in a sample DNA comprising a target sequence containing a dinucleotide consisting of C that may be methylated and a nucleotide on the 3′ side of the C (CpN dinucleotide) is determined based on a result of hybridization performed for a plurality of capture oligonucleotides immobilized on a base material and including at least an oligonucleotide having a nucleotide sequence complimentary to or identical to a nucleotide sequence corresponding to the target sequence in which C other than C in the CpN dinucleotide is replaced with T and an oligonucleotide having a nucleotide sequence complimentary to or identical to a nucleotide sequence corresponding to the target sequence in which all of C's are replaced with T's and the sample DNA in which cytosines not methylated are converted into uracils by deamination or an amplification product thereof.Type: ApplicationFiled: November 14, 2002Publication date: May 22, 2003Inventors: Osamu Suzuki, Tatsuo Ichihara
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Publication number: 20030049668Abstract: A novel mutation in the gyrase A gene involved in quinolon resistance phenotype acquisition of tubercle bacillus is identified and utilized to provide a method and kit for determining quinolon resistance of tubercle bacillus.Type: ApplicationFiled: August 15, 2002Publication date: March 13, 2003Inventors: Yasuhiko Suzuki, Tatsuo Ichihara, Noriko Satoh
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Publication number: 20020127592Abstract: Poly(A)+ RNA extracted from a cell or a tissue is amplified by the following steps of:Type: ApplicationFiled: March 7, 2002Publication date: September 12, 2002Inventors: Tatsuo Ichihara, Shogo Moriya
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Publication number: 20020018996Abstract: A nucleic acid to be immobilized and used for hybridization of nucleic acids using an immobilized nucleic acid, which has a polymer comprising a compound having an unsaturated bond, said polymer being bonded to the 3′ end or 5′ end or both ends of the nucleic acid; a nucleic acid-immobilized substrate comprising a substrate for immobilizing a nucleic acid and the polymer-having nucleic acid immobilized on the substrate; and a method for detecting a nucleic acid by hybridization using an immobilized nucleic acid, which comprises using the nucleic acid-immobilized substrate.Type: ApplicationFiled: January 26, 2001Publication date: February 14, 2002Inventors: Naoki Kimura, Tatsuo Ichihara, Shogo Moriya
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Patent number: 5908746Abstract: A method is provided, comprising the steps of reacting a biologically active first substance immobilized on a carrier with a second substance capable of specifically binding the first substance, and detecting a non-bound part of the second substance or a bound part of the second substance indirectly bound to the carrier through binding between the first and second substances so that the first substance or the second substance in a sample is analyzed, wherein the carrier carries a compound having 2 to 100 carbodiimide groups, and the first substance is immobilized on the carrier through the carbodiimide groups so that the active substance such as protein and nucleic acid is bound to the carrier conveniently, efficiently, and tightly.Type: GrantFiled: June 7, 1996Date of Patent: June 1, 1999Assignee: Nisshinbo Industries, Inc.Inventors: Osamu Suzuki, Naokazu Sasaki, Tatsuo Ichihara, Sanae Okada
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Patent number: 5789588Abstract: The present invention relates to a carbodiimide derivative represented by the following general formula:W.sub.1 --X--N.dbd.C.dbd.N--Y--W.sub.2 --Zwherein W.sub.1 is a straight chain, branched chain or cyclic saturated or unsaturated aliphatic hydrocarbon group, a substituted or unsubstituted aryl group, a heteroaryl group, a tertiary amino group or a tertiary or quaternary ammonium group; --W.sub.2 --Z is a quaternary ammonium group; X and Y are each independently a single bond or an alkylene group; and Z is a biotin group represented by the following formula: ##STR1## wherein n is 0 or 1. The derivative is useful as a label reagent for introducing a biotin group into a nucleic acid or a protein.Type: GrantFiled: September 16, 1997Date of Patent: August 4, 1998Assignee: Nisshinbo Industries, Inc.Inventors: Soichiro Takenishi, Osamu Suzuki, Hirohiko Yokomizo, Tatsuo Ichihara, Gen Masuda, Namiko Nakajima, Kazuko Komiya
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Patent number: 5700935Abstract: The present invention relates to a carbodiimide derivative represented by the following general formula:W.sub.1 --X--N.dbd.C.dbd.N--Y--W.sub.2 --Zwherein W.sub.1 is a straight chain, branched chain or cyclic saturated or unsaturated aliphatic hydrocarbon group, a substituted or unsubstituted aryl group, a heteroaryl group, tertiary amino group or a tertiary or quaternary ammonium group; --W.sub.2 --Z is a quaternary ammonium group; X and Y are each independently a single bond or an alkylene group; and Z is a biotin group represented by the following formula: ##STR1## wherein n is 0 or 1. The derivative is useful as a label reagent for introducing a biotin group into a nucleic acid or a protein.Type: GrantFiled: December 22, 1995Date of Patent: December 23, 1997Assignee: Nisshinbo Industries, Inc.Inventors: Soichiro Takenishi, Osamu Suzuki, Hirohiko Yokomizo, Tatsuo Ichihara, Gen Masuda, Namiko Nakajima, Kazuko Komiya