Patents by Inventor Tatsuo Nagano

Tatsuo Nagano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors against the production and release of inflammatory cytokines
    Patent number: 8263657
    Abstract: A medicament having inhibitory activity against NF-?B activation, which comprises a compound represented by the following general formula (I) or a pharmacologically acceptable salt as an active ingredient: wherein X represents a connecting group, A represents hydrogen atom or acetyl group, E represents an aryl group or a heteroaryl group, and ring X represents an arene or a heteroarene.
    Type: Grant
    Filed: December 18, 2001
    Date of Patent: September 11, 2012
    Assignee: Institute of Medicinal Molecular Design, Inc.
    Inventors: Susumu Muto, Tatsuo Nagano, Tomomi Sotome, Akiko Itai
  • Inflammatory cytokine release inhibitor
    Patent number: 8097759
    Abstract: A medicament having inhibitory activity against NF-?B activation, which comprises a compound represented by the following general formula (I) or a pharmacologically acceptable salt as an active ingredient: wherein X represents a connecting group, A represents hydrogen atom or acetyl group, E represents an aryl group or a heteroaryl group, and ring X represents an arene or a heteroarene.
    Type: Grant
    Filed: July 2, 2010
    Date of Patent: January 17, 2012
    Assignee: Institute of Medicinal Molecular Design, Inc.
    Inventors: Susumu Muto, Tatsuo Nagano, Tomomi Sotome, Akiko Itai
  • INFLAMMATORY CYTOKINE RELEASE INHIBITOR
    Publication number: 20100274051
    Abstract: A medicament having inhibitory activity against NF-?B activation, which comprises a compound represented by the following general formula (I) or ? pharmacologically acceptable salt as an active ingredient: wherein X represents a connecting group, A represents hydrogen atom or acetyl group, E represents an aryl group or a heteroaryl group, and ring X represents an arene or a heteroarene.
    Type: Application
    Filed: July 2, 2010
    Publication date: October 28, 2010
    Applicant: Institute of Medicinal Molecular Design. Inc.
    Inventors: Susumu MUTO, Tatsuo Nagano, Tomomi Sotome, Akiko Itai
  • INFLAMMATORY CYTOKINE RELEASE INHIBITOR
    Publication number: 20090192122
    Abstract: A medicament having inhibitory activity against NF-?B activation, which comprises a compound represented by the following general formula (I) or a pharmacologically acceptable salt as an active ingredient: wherein X represents a connecting group, A represents hydrogen atom or acetyl group, E represents an aryl group or a heteroaryl group, and ring X represents an arene or a heteroarene.
    Type: Application
    Filed: August 8, 2007
    Publication date: July 30, 2009
    Applicant: INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC.
    Inventors: Susumu MUTO, Tatsuo NAGANO, Tomomi SOTOME, Akiko ITAI
  • INFLAMMATORY CYTOKINE RELEASE INHIBITOR
    Publication number: 20080318956
    Abstract: A medicament having inhibitory activity against NF-?B activation, which comprises a compound represented by the following general formula (I) or a pharmacologically acceptable salt as an active ingredient: wherein X represents a connecting group, A represents hydrogen atom or acetyl group, E represents an aryl group or a heteroaryl group, and ring X represents an arene or a heteroarene.
    Type: Application
    Filed: August 8, 2007
    Publication date: December 25, 2008
    Applicant: INSTITUTE OF MEDICINAL MOLECULAR DESIGN. INC.
    Inventors: Susumu MUTO, Tatsuo NAGANO, Tomomi SOTOME, Akiko ITAI
  • INFLAMMATORY CYTOKINE RELEASE INHIBITOR
    Publication number: 20080249071
    Abstract: A medicament having inhibitory activity against NF-?B activation, which comprises a compound represented by the following general formula (I) or a pharmacologically acceptable salt as an active ingredient: wherein X represents a connecting group, A represents hydrogen atom or acetyl group, E represents an aryl group or a heteroaryl group, and ring X represents an arene or a heteroarene.
    Type: Application
    Filed: August 8, 2007
    Publication date: October 9, 2008
    Applicant: INSTITUTE OF MEDICINAL MOLECULAR DESIGN. INC.
    Inventors: Susumu MUTO, Tatsuo NAGANO, Tomomi SOTOME, Akiko ITAI
  • Inhibitors against the production and release of inflammatory cytokines
    Publication number: 20040259877
    Abstract: A medicament having inhibitory activity against NF-&kgr;B activation, which comprises a compound represented by the following general formula (I) or a pharmacologically acceptable salt as an active ingredient: 1
    Type: Application
    Filed: February 19, 2004
    Publication date: December 23, 2004
    Inventors: Susumu Muto, Tatsuo Nagano, Tomomi Sotome, Akiko Itai
  • Monohydrates of aminobenzenesulfonic acid derivatives and method for preparing thereof
    Patent number: 6245767
    Abstract: A monohydrate of an aminobenzenesulfonic acid derivative represented by the following formula (I), for example, 2-(1-piperazinyl)-5-methylbenzenesulfonic acid, is substantially free from weight change due to moisture absorption and can be weighed accurately in manufacturing a pharmaceutical composition for the treatment of heart diseases comprising said monohydrate.
    Type: Grant
    Filed: September 24, 1999
    Date of Patent: June 12, 2001
    Assignee: Mitsubishi Chemical Corporation
    Inventors: Chika Yamazaki, Tadao Sato, Tatsuo Nagano
  • Monohydrates of aminobenzenesulfonic acid derivatives and method for preparing thereof
    Patent number: 5990113
    Abstract: A monohydrate of an aminobenzenesulfonic acid derivative represented by the following formula (I), for example, 2-(1-piperazinyl)-5-methylbenzenesulfonic acid, is substantially free from weight change due to moisture absorption and can be weighed accurately in manufacturing a pharmaceutical composition for the treatment of heart diseases comprising said monohydrate.
    Type: Grant
    Filed: December 16, 1996
    Date of Patent: November 23, 1999
    Assignee: Mitsubishi Chemical Corporation
    Inventors: Chika Yamazaki, Tadao Sato, Tatsuo Nagano
  • Imidazoyl-.beta.-oxo-.beta.-benzenepropanethiomide derivative, compositions and method of use thereof
    Patent number: 5439927
    Abstract: The .beta.-oxo-.beta.-benzenepropanethioamide derivative of the present invention has potassium channel opening action and is useful for treatment of hypertension, asthma, hypersensitive colon syndrome, and enteritis through pharmacological actions including blood vessel dilation, bronchial tract dilation, relaxation of gastrointestinal tract smooth muscle, and the like. The present invention also includes a pharmaceutical composition containing, as the active ingredient, the compound of the present invention and a method for producing the same.
    Type: Grant
    Filed: April 22, 1994
    Date of Patent: August 8, 1995
    Assignee: Mitsubishi Kasei Corporation
    Inventors: Tetsuo Sekiya, Mikio Tsutsui, Tetsuro Shimpuku, Tatsuo Nagano, Junko Hayashi, Asami Seino
  • .beta.-oxo-.beta.-benzenepropanethioamide compounds
    Patent number: 5332833
    Abstract: The .beta.-oxo-.beta.-benzenepropanethioamide derivative of the present invention has potassium channel opening action and is useful for treatment of hypertension, asthma, hypersensitive colon syndrome, and enteritis through pharmacological actions including blood vessel dilation, bronchial tract dilation, relaxation of gastrointestinal tract smooth muscle, and the like. The present invention also includes a pharmaceutical composition containing, as the active ingredient, the compound of the present invention and a method for producing the same.
    Type: Grant
    Filed: December 23, 1992
    Date of Patent: July 26, 1994
    Assignee: Mitsubishi Kasei Corporation
    Inventors: Tetsuo Sekiya, Mikio Tsutsui, Tetsuro Shimpuku, Tatsuo Nagano, Junko Hayashi, Asami Seino