Abstract: A mixer-granulator drier comprises a mixer-granulator having main and auxiliary mixing-granulating blades mounted in a vessel forming the main body so that both the blades are revolved to accomplish mixing and granulation of powders as desired. The bottom plate of the vessel is formed with a number of slots, a valve mechanism for opening and closing the slots are located adjacent the slots, and a drying-air supply device is provided for supplying the vessel with drying air through the slots. This combination apparatus performs mixing, granulation, and drying of various drugs, foods, chemicals, etc., in a single vessel automatically and continuously. The apparatus is easy to disassemble for thorough cleaning and sterilization.