Patents by Inventor Tatsuo Ohtsuka

Tatsuo Ohtsuka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polycyclic compounds exhibiting anti-tumor activities
    Patent number: 6946472
    Abstract: This invention is concerned with novel polycyclic compounds of formula [I], wherein ring A, ring B, R1, R2, R3, R4, R5, R6, X, Y, R1?, R2?, R3?, R4?, R5?, R6?, ring A?, ring B? and X? are as defined hereinabove as well as pharmaceutically acceptable salts thereof. The compounds have anti-tumor activity and are useful for the treatment of cell proliferative disorders.
    Type: Grant
    Filed: April 16, 2003
    Date of Patent: September 20, 2005
    Assignee: Hoffman-La Roche Inc.
    Inventors: Kenichi Kawasaki, Tatsuo Ohtsuka, Kiyoaki Sakata
  • Polycyclic compounds
    Patent number: 6680326
    Abstract: Novel polycyclic compounds of the formula [I], wherein R1, R2, R3, R4, R5, R6, R7, ring A, ring B, X, Y and Z are as defined herein and the pharmaceutically acceptable salts thereof. These compounds have antitumor activity and useful for the treatment of cancer.
    Type: Grant
    Filed: September 25, 2002
    Date of Patent: January 20, 2004
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Tsunehisa Aoyama, Kenichi Kawasaki, Miyako Masubuchi, Tatsuo Ohtsuka, Kiyoaki Sakata
  • Polycyclic compounds exhibiting anti-tumor activities
    Publication number: 20030229098
    Abstract: This invention is concerned with novel polycyclic compounds of formula [I], 1
    Type: Application
    Filed: April 16, 2003
    Publication date: December 11, 2003
    Inventors: Kenichi Kawasaki, Tatsuo Ohtsuka, Kiyoaki Sakata
  • Polycyclic compounds
    Publication number: 20030073691
    Abstract: Novel polycyclic compounds of the formula [I], 1
    Type: Application
    Filed: September 25, 2002
    Publication date: April 17, 2003
    Inventors: Tsunehisa Aoyama, Kenichi Kawasaki, Miyako Masubuchi, Tatsuo Ohtsuka, Kiyoaki Sakata
  • Bicyclic compounds
    Patent number: 6376491
    Abstract: The present invention is directed to new bicyclic compounds of the formula [I], and pharmaceutically acceptable salts thereof wherein R1, R2, R3, R4, R5, R6, R7, Q1 Q2 and Q3 are as defined in the claims. The compounds have N-myristoyltransferase inhibitory and antifungal activity.
    Type: Grant
    Filed: December 15, 1999
    Date of Patent: April 23, 2002
    Assignee: Basilea Pharmaceutica AG
    Inventors: Yuhko Aoki, Hirosato Ebiike, Toshihiko Fujii, Kenichi Kawasaki, Pingli Liu, Miyako Masubuchi, Tatsuo Ohtsuka, Shinji Tsujii
  • Hispidospermidin
    Patent number: 5430050
    Abstract: The compound of formula, ##STR1## is obtained from cultures of Chaetosphaeronema hispidulum. The compound is an inhibitor of phospholipase C.
    Type: Grant
    Filed: November 22, 1993
    Date of Patent: July 4, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Tatsuo Ohtsuka, Akiko Sakai, Toru Okuda
  • Pyrido(3,2,1-IJ)-1,3,4-benzoxadiazine derivatives
    Patent number: 4864023
    Abstract: The invention is concerned with tricyclic compounds of the formula ##STR1## wherein R.sup.1 is a hydrogen atom or a carboxy-protecting radical; R.sup.2 is a hydrogen atom or a lower alkyl radical which may be substituted with a halogen atom; R.sup.3 and R.sup.4 independently are a hydrogen atom or a lower alkyl radical which may be substituted with a hydroxy radical or a substituted or unsubstituted amino radical; X is a halogen atom; and R.sup.5 and R.sup.6 are independently a hydrogen atom or a lower alkyl radical which may be substituted with a hydroxy radical, a lower alkoxy radical or a substituted or unsubstituted amino radical; or R.sup.5 and R.sup.6, taken together with the adjacent nitrogen atom, may form a 5 to 7 membered heterocyclic ring which may be substituted with one or more substituents at the carbon atom(s), and the heterocyclic ring may further contain --NR.sup.7 --, --O--, --S--, --SO--, --SO.sub.2 -- or --NR.sup.7 --CO--, and also R.sup.
    Type: Grant
    Filed: August 26, 1988
    Date of Patent: September 5, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Kazuteru Yokose, Nobuo Shimma, Mikayo Kamata, Masahiro Aoki, Tatsuo Ohtsuka
  • Pyrido(3,2,1-IJ)-1,3,4 benzoxadiazine derivatives
    Patent number: 4801584
    Abstract: The invention is concerned with tricyclic compounds of the formula ##STR1## wherein R.sup.1 is a hydrogen atom or a carboxy-protecting radical; R.sup.2 is a hydrogen atom or a lower alkyl radical which may be substituted with a halogen atom; R.sup.3 and R.sup.4 independently are a hydrogen atom or a lower alkyl radical which may be substituted with a hydroxy radical or a substituted or unsubstituted amino radical; X is a halogen atom; and R.sup.5 and R.sup.6 are independently a hydrogen atom or a lower alkyl radical which may be substituted with a hydroxy radical, a lower alkoxy radical or a substituted or unsubstituted amino radical; or R.sup.5 and R.sup.6, taken together with the adjacent nitrogen atom, may form a 5 to 7 membered heterocyclic ring which may be substituted with one or more substituents at the carbon atom(s), and the heterocyclic ring may further contain --NR.sup.7 --, --O--, --S--, --SO--, --SO.sub.2 -- or --NR.sup.7 --CO--, and also R.sup.
    Type: Grant
    Filed: September 8, 1987
    Date of Patent: January 31, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Kazuteru Yokose, Nobuo Shimma, Miyako Kamata, Masahiro Aoki, Tatsuo Ohtsuka