Abstract: A support for enzyme immobilization is described, which is for immobilizing enzymes of various molecular sizes and also for, due to the modification of the surface silanol groups of porous silica particles, for immobilizing various kinds of enzymes, and enables the design of an immobilized enzyme, which exhibits an activity equivalent to that of the corresponding non-immobilized enzyme and withstands repeated use. A method for producing the support is also described. The support includes porous silica particles having an interparticle void structure therein, characterized in that the porous silica particles have a specific average particle size, a specific surface area, a specific pore volume, a specific pore size distribution and a specific porosity and have a substituent containing an organic group or an amino group on the surface thereof. An immobilized protein obtained by immobilizing a protein on the above support is also described.

Abstract: It is an object of the present invention to provide: a protein refolding column filler, which is effective for the refolding, namely, the activation of the function, of an inactive protein with an as yet unformed higher order structure produced in Escherichia coli or the like, or a protein whose conformation has been changed due to a certain cause and which has become inactivated; and a column filled with the aforementioned column filler. The present invention provides a protein refolding column filler, which comprises zeolite with BEA structure (Zeolite Beta) that is granulated into a particle state.

Abstract: To provide a right angle type spring connector in which a caulking work is not necessary, the number of components is small, and electric connection is reliably maintained. The right angle type spring connector is configured as follows. A tube is formed with a narrowed portion so as to allow a distal end portion of a pin to project therefrom and prevent the pin from coming out. A connecting portion disposed on the tube and extending to a mounting surface and amounting surface abutting portion extending along the mounting surface are formed integrally with each other, and an engaging portion is provided on the mounting surface abutting portion. A holder is formed with a bottomed hole so as to allow the tube to be inserted. A locking portion is formed on the holder so as to engage the engaging portion in a state in which the tube is inserted into the bottomed hole.

Abstract: It is an object of the present invention to provide: a protein refolding column filler, which is effective for the refolding, namely, the activation of the function, of an inactive protein with an as yet unformed higher order structure produced in Escherichia coli or the like, or a protein whose conformation has been changed due to a certain cause and which has become inactivated; and a column filled with the aforementioned column filler. The present invention provides a protein refolding column filler, which comprises zeolite with BEA structure (Zeolite Beta) that is granulated into a particle state.

Abstract: To provide a right angle type spring connector in which a caulking work is not necessary, the number of components is small, and electric connection is reliably maintained. The right angle type spring connector is configured as follows. A tube is formed with a narrowed portion so as to allow a distal end portion of a pin to project therefrom and prevent the pin from coming out. A connecting portion disposed on the tube and extending to a mounting surface and amounting surface abutting portion extending along the mounting surface are formed integrally with each other, and an engaging portion is provided on the mounting surface abutting portion. A holder is formed with a bottomed hole so as to allow the tube to be inserted. A locking portion is formed on the holder so as to engage the engaging portion in a state in which the tube is inserted into the bottomed hole.

Abstract: A device for electrically exciting tissue in the uveal and periuveal areas of the eye includes a frame similar to an eyeglass frame in shape and construction. Two flat, disk-shaped electrodes are attached to the frame. When the frame is placed on the head of the patient, the electrodes are positioned adjacent the orbits of the patient's eyes. A voltage source and electronic circuitry is provided to establish a voltage differential between the electrodes thereby allowing electrical currents to flow from one electrode to the other, stimulating the tissue and other cells in the uveal and periuveal areas of the eyes. Alternatively, the patient's body can be isolated from ground and the voltage source used to place a negative charge on each electrode to thereby create beneficial negative ions in the uveal and periuveal areas of each eye.

Abstract: Disclosed is a laser apparatus having an optical pumping source, first and second resonator mirrors, a laser medium provided on a light route between the first and second resonator mirrors, an optical system provided in a light route between the laser medium and the second resonator mirror; and a nonlinear optical crystal for generating through wavelength conversion a higher harmonic wave(s) from a fundamental wave of laser generated by the laser medium. The nonlinear optical crystal is capable of being inserted between the intermediate optical system and the second resonator mirror. The second resonator mirror is a concave mirror. The intermediate optical system is constituted by a single concave mirror reflecting the fundamental wave and transmitting the higher harmonic wave(s).