Patents by Inventor Tatsuro KANAKI
Tatsuro KANAKI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240132827Abstract: A separation device for separating a solid separation target contained in a suspension obtained by suspension culture of adherent cells by using a fine scaffold material, and a separation method. The separation device has a separation chamber having a first chamber and a second chamber, and the first chamber and the second chamber are divided by a mesh structure for separation. The mesh structure for separation has mesh-holes with a predetermined size to suppress passage of the separation target, and a mesh structure for separation is configured in the separation chamber such that the liquid in the aforementioned suspension has a vertically upward directional component in the advancing direction of the liquid when the liquid passes through the mesh-holes.Type: ApplicationFiled: November 22, 2023Publication date: April 25, 2024Applicant: NISSAN CHEMICAL CORPORATIONInventors: Daisuke HATANAKA, Katsuhiko KIDA, Tatsuro KANAKI, Hisato HAYASHI
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Publication number: 20240084296Abstract: The invention provides a single-stranded oligonucleotide represented by the formula (I), wherein X and Y hybridize by a first nucleotide sequence portion and a second nucleotide sequence portion. X is composed of 7 to 100 nucleotides, contains at least one modified-nucleotide, and has a first nucleotide sequence capable of hybridizing with a second oligonucleotide. Y is composed of 4 to 100 nucleotides, enables hybridization with the above-mentioned first oligonucleotide, and has a second nucleotide sequence containing at least one ribonucleotide. At least one of the nucleotide sequences X, Xz and Y has an antisense sequence capable of hybridizing with a target RNA. At least one of L, Lx and Ly is a linking group that contains a non-nucleotide structure.Type: ApplicationFiled: February 1, 2023Publication date: March 14, 2024Applicant: NISSAN CHEMICAL CORPORATIONInventors: Yusuke IRIYAMA, Hiroyuki NAKAJIMA, Tatsuro KANAKI, Masatoshi NIWA
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Publication number: 20230383245Abstract: The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition having an effect of preventing sedimentation of cells and/or tissues, which is afforded by substantially retaining the cells and/or tissues, without substantially increasing the viscosity of the solution, by nanofibers which have been added to the solution and uniformly dispersed in the liquid medium, and the like.Type: ApplicationFiled: August 8, 2023Publication date: November 30, 2023Applicant: NISSAN CHEMICAL CORPORATIONInventors: Hisato HAYASHI, Misayo OTANI, Koichiro SARUHASHI, Taito NISHINO, Takehisa IWAMA, Tatsuro KANAKI, Ayako AIHARA
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Publication number: 20230203498Abstract: Provided is a single-stranded oligonucleotide that is capable of controlling a target gene with high efficiency and can be easily produced. The single-stranded oligonucleotide is represented by the formula X-L-Y wherein X and Y hybridize by a first nucleotide sequence portion and a second nucleotide sequence portion. X is composed of 7 to 100 nucleotides, contains at least one modified nucleotide, and has a first nucleotide sequence that is capable of hybridizing with a second oligonucleotide and contains at least four contiguous nucleotides recognized by RNase H. Y is composed of 4 to 100 nucleotides, and has a second nucleotide sequence that is capable of hybridizing with a second oligonucleotide and contains at least one ribonucleotide. At least one of nucleotide sequence X and nucleotide sequence Y has an antisense sequence capable of hybridizing with a target RNA. L is a group derived from a third oligonucleotide that is degraded under physiological conditions.Type: ApplicationFiled: November 11, 2022Publication date: June 29, 2023Applicant: NISSAN CHEMICAL CORPORATIONInventors: Yusuke IRIYAMA, Hiroyuki NAKAJIMA, Tatsuro KANAKI
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Publication number: 20230183702Abstract: The invention provides a single-stranded oligonucleotide represented by the formula [Xz — Lx]m — X — Y — [Ly — Yz]n, wherein X is represented by Xa-Xb, Xa is coupled with Y, and Xb and Y hybridize. Xa is composed of 1 to 40 nucleotides and contains at least one modified-nucleotide. Xb is composed of 4 to 40 nucleotides and contains at least one modified-nucleotide. Y is composed of 4 to 40 nucleotides and contains at least one ribonucleotide. Xz and Yz are composed of 5 to 40 nucleotides and contain at least one modified-nucleotide. Nucleotide sequences X, Xz and Yz have an antisense sequence capable of hybridizing with a target RNA. Lx and Ly are composed of 0 to 20 nucleotides.Type: ApplicationFiled: January 10, 2023Publication date: June 15, 2023Applicant: NISSAN CHEMICAL CORPORATIONInventors: Yusuke IRIYAMA, Hiroyuki NAKAJIMA, Tatsuro KANAKI
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Patent number: 11572558Abstract: The invention provides a single-stranded oligonucleotide represented by the formula (I), wherein X and Y hybridize by a first nucleotide sequence portion and a second nucleotide sequence portion. X is composed of 7 to 100 nucleotides, contains at least one modified-nucleotide, and has a first nucleotide sequence capable of hybridizing with a second oligonucleotide. Y is composed of 4 to 100 nucleotides, enables hybridization with the above-mentioned first oligonucleotide, and has a second nucleotide sequence containing at least one ribonucleotide. At least one of the nucleotide sequences X, Xz and Y has an antisense sequence capable of hybridizing with a target RNA. At least one of L, Lx and Ly is a linking group that contains a non-nucleotide structure.Type: GrantFiled: February 6, 2018Date of Patent: February 7, 2023Assignee: NISSAN CHEMICAL CORPORATIONInventors: Yusuke Iriyama, Hiroyuki Nakajima, Tatsuro Kanaki, Masatoshi Niwa
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Patent number: 11555188Abstract: The invention provides a single-stranded oligonucleotide represented by the formula [Xz-Lx]m-X-Y-[Ly-Yz]n, wherein X is represented by Xa-Xb, Xa is coupled with Y, and Xb and Y hybridize. Xa is composed of 1 to 40 nucleotides and contains at least one modified-nucleotide. Xb is composed of 4 to 40 nucleotides and contains at least one modified-nucleotide. Y is composed of 4 to 40 nucleotides and contains at least one ribonucleotide. Xz and Yz are composed of 5 to 40 nucleotides and contain at least one modified-nucleotide. Nucleotide sequences X, Xz and Yz have an antisense sequence capable of hybridizing with a target RNA. Lx and Ly are composed of 0 to 20 nucleotides.Type: GrantFiled: July 26, 2018Date of Patent: January 17, 2023Assignee: NISSAN CHEMICAL CORPORATIONInventors: Yusuke Iriyama, Hiroyuki Nakajima, Tatsuro Kanaki
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Patent number: 11530387Abstract: The present invention provides a method for producing a unilocular adipocyte including inducing differentiation into unilocular adipocytes of mesenchymal cells having differentiation potency into adipocytes by culturing the mesenchymal cells in suspension in a liquid medium composition capable of culturing cells or tissues in suspension, wherein the liquid medium composition contains a polymer compound having an anionic functional group that binds via a divalent metal cation to form a structure capable of suspending cells or tissues, and the method wherein the polymer compound is polysaccharide, preferably polysaccharide containing a glucuronic acid moiety, more preferably deacylated gellan gum, diutan gum or xanthan gum or a salt thereof.Type: GrantFiled: November 16, 2018Date of Patent: December 20, 2022Assignee: NISSAN CHEMICAL CORPORATIONInventor: Tatsuro Kanaki
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Patent number: 11530409Abstract: Provided is a single-stranded oligonucleotide that is capable of controlling a target gene with high efficiency and can be easily produced. The single-stranded oligonucleotide is represented by the formula X-L-Y wherein X and Y hybridize by a first nucleotide sequence portion and a second nucleotide sequence portion. X is composed of 7 to 100 nucleotides, contains at least one modified nucleotide, and has a first nucleotide sequence that is capable of hybridizing with a second oligonucleotide and contains at least four contiguous nucleotides recognized by RNase H. Y is composed of 4 to 100 nucleotides, and has a second nucleotide sequence that is capable of hybridizing with a second oligonucleotide and contains at least one ribonucleotide. At least one of nucleotide sequence X and nucleotide sequence Y has an antisense sequence capable of hybridizing with a target RNA. L is a group derived from a third oligonucleotide that is degraded under physiological conditions.Type: GrantFiled: January 26, 2017Date of Patent: December 20, 2022Assignee: NISSAN CHEMICAL CORPORATIONInventors: Yusuke Iriyama, Hiroyuki Nakajima, Tatsuro Kanaki
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Publication number: 20220364050Abstract: A method for producing a medium composition for suspension culture of an adherent cell, including the following steps: (i) a step of making an extracellular matrix carried on a nanofiber composed of water-insoluble polysaccharides, (ii) a step of adding the extracellular matrix-carrying nanofiber obtained in step (i) to a medium is provided by the present invention.Type: ApplicationFiled: July 3, 2020Publication date: November 17, 2022Applicant: NISSAN CHEMICAL CORPORATIONInventors: Daisuke HATANAKA, Tatsuro KANAKI, Hisato HAYASHI
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Publication number: 20220306985Abstract: The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the likeType: ApplicationFiled: May 23, 2022Publication date: September 29, 2022Applicants: Nissan Chemical Industries, Ltd., Kyoto UniversityInventors: Taito NISHINO, Tatsuro KANAKI, Ayako OTANI, Koichiro SARUHASHI, Misayo Tomura, Takehisa IWAMA, Masato HORIKAWA, Norio NAKATSUJI, Tomomi OTSUJI
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Publication number: 20220267480Abstract: The present invention provides a method capable of easily mixing any liquid containing a linking substance such as a divalent metal cation and the like with a liquid containing a particular compound at a high concentration, and capable of producing a liquid medium composition comprising fine structures dispersed therein, and a production device therefor and a kit therefor. The first liquid containing a particular compound is passed through a through-hole having a given cross-sectional area formed in a nozzle part at a given flow rate and injected into the second liquid at a given flow rate. By this simple operation, a structure in which the particular compound is bonded via the linking substance is formed, and the structure is preferably dispersed in a mixture of the both liquids.Type: ApplicationFiled: May 11, 2022Publication date: August 25, 2022Applicant: NISSAN CHEMICAL INDUSTRIES, LTD.Inventors: Hisato HAYASHI, Koichiro SARUHASHI, Tatsuro KANAKI
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Patent number: 11384112Abstract: Provided is an artificial nucleoside or artificial nucleotide capable of composing an artificial oligonucleotide having superior nuclease resistance. The artificial nucleoside or artificial nucleotide is a compound represented by formula (I) or a salt thereof (wherein, Bx represents a pyrimidine base or purine base, R1, R2, R3 and R4 represent hydrogen atoms, C1-6 alkyl groups or the like, Y represents NR5R6 (wherein, R5 and R6, independently of each other, represent a hydrogen atom, C1-6 alkyl group or the like, or R5 and R6, together with a nitrogen atom bound thereto, form a 3- to 11-membered nitrogen-containing non-aromatic heterocyclic group) or an optionally substituted C2-9 aromatic heterocyclic group, Z1 and Z2 represent hydrogen atoms, hydroxyl group-protecting groups, phosphorous-containing groups or the like, and n represents an integer of 1 to 3).Type: GrantFiled: February 17, 2017Date of Patent: July 12, 2022Assignees: TOKYO INSTITUTE OF TECHNOLOGY, NISSAN CHEMICAL CORPORATIONInventors: Kohji Seio, Yoshiaki Masaki, Keishi Yamamoto, Keita Yoshida, Yusuke Iriyama, Hiroyuki Nakajima, Tatsuro Kanaki
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Patent number: 11371013Abstract: The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the like.Type: GrantFiled: February 26, 2020Date of Patent: June 28, 2022Assignees: Nissan Chemical Industries, Ltd., Kyoto UniversityInventors: Taito Nishino, Tatsuro Kanaki, Ayako Otani, Koichiro Saruhashi, Misayo Tomura, Takehisa Iwama, Masato Horikawa, Norio Nakatsuji, Tomomi Otsuji
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Patent number: 11345762Abstract: The present invention provides a method capable of easily mixing any liquid containing a linking substance such as a divalent metal cation and the like with a liquid containing a particular compound at a high concentration, and capable of producing a liquid medium composition comprising fine structures dispersed therein, and a production device therefor and a kit therefor. The first liquid containing a particular compound is passed through a through-hole having a given cross-sectional area formed in a nozzle part at a given flow rate and injected into the second liquid at a given flow rate. By this simple operation, a structure in which the particular compound is bonded via the linking substance is formed, and the structure is preferably dispersed in a mixture of the both liquids.Type: GrantFiled: April 7, 2016Date of Patent: May 31, 2022Assignee: NISSAN CHEMICAL INDUSTRIES, LTD.Inventors: Hisato Hayashi, Koichiro Saruhashi, Tatsuro Kanaki
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Publication number: 20220041971Abstract: A separation device for separating a solid separation target contained in a suspension obtained by suspension culture of adherent cells by using a fine scaffold material, and a separation method. The separation device has a separation chamber having a first chamber and a second chamber, and the first chamber and the second chamber are divided by a mesh structure for separation. The mesh structure for separation has mesh-holes with a predetermined size to suppress passage of the separation target, and a mesh structure for separation is configured in the separation chamber such that the liquid in the aforementioned suspension has a vertically upward directional component in the advancing direction of the liquid when the liquid passes through the mesh-holes.Type: ApplicationFiled: September 11, 2019Publication date: February 10, 2022Applicant: NISSAN CHEMICAL CORPORATIONInventors: Daisuke HATANAKA, Katsuhiko KIDA, Tatsuro KANAKI, Hisato HAYASHI
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Publication number: 20210340491Abstract: The present invention provide a medium composition for suspension culture of an adherent cell, containing (1) a chitin nanofiber; and (2) a chitosan nanofiber or a polysaccharide.Type: ApplicationFiled: August 30, 2019Publication date: November 4, 2021Applicant: NISSAN CHEMICAL CORPORATIONInventors: Tatsuro KANAKI, Katsuhiko KIDA, Masataka MINAMI, Daisuke HATANAKA
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Publication number: 20210254055Abstract: The invention provides a single-stranded oligonucleotide represented by the formula (I), wherein X and Y hybridize by a first nucleotide sequence portion and a second nucleotide sequence portion. X is composed of 7 to 100 nucleotides, contains at least one modified-nucleotide, and has a first nucleotide sequence capable of hybridizing with a second oligonucleotide. Y is composed of 4 to 100 nucleotides, enables hybridization with the above-mentioned first oligonucleotide, and has a second nucleotide sequence containing at least one ribonucleotide. At least one of the nucleotide sequences X, Xz and Y has an antisense sequence capable of hybridizing with a target RNA. At least one of L, Lx and Ly is a linking group that contains a non-nucleotide structure.Type: ApplicationFiled: February 6, 2018Publication date: August 19, 2021Applicant: NISSAN CHEMICAL CORPORATIONInventors: Yusuke IRIYAMA, Hiroyuki NAKAJIMA, Tatsuro KANAKI, Masatoshi NIWA
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Publication number: 20210188894Abstract: Provided is an artificial nucleoside or artificial nucleotide capable of composing an artificial oligonucleotide having superior nuclease resistance. The artificial nucleoside or artificial nucleotide is a compound represented by formula (I) or a salt thereof (wherein, Bx represents a pyrimidine base or purine base, R1, R2, R3 and R4 represent hydrogen atoms, C1-6 alkyl groups or the like, Y represents NR5R6 (wherein, R5 and R6, independently of each other, represent a hydrogen atom, C1-6 alkyl group or the like, or R5 and R6, together with a nitrogen atom bound thereto, form a 3- to 11-membered nitrogen-containing non-aromatic heterocyclic group) or an optionally substituted C2-9 aromatic heterocyclic group, Z1 and Z2 represent hydrogen atoms, hydroxyl group-protecting groups, phosphorous-containing groups or the like, and n represents an integer of 1 to 3).Type: ApplicationFiled: February 17, 2017Publication date: June 24, 2021Applicants: TOKYO INSTITUTE OF TECHNOLOGY, NISSAN CHEMICAL CORPORATIONInventors: Kohji SEIO, Yoshiaki MASAKI, Keishi YAMAMOTO, Keita YOSHIDA, Yusuke IRIYAMA, Hiroyuki NAKAJIMA, Tatsuro KANAKI
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Publication number: 20210054377Abstract: The invention provides an antisense oligonucleotide reduced in toxicity. The antisense oligonucleotide has a central region, a 5?-side region and a 3?-side region, wherein the central region has a nucleotide (2?-3? bridged nucleotide) in which the 2?-position and the 3?-position of a sugar moiety are bridged and/or a non-bridged nucleotide (3?-position-modified non-bridged nucleotide) having a substituent at the 3?-position.Type: ApplicationFiled: March 20, 2019Publication date: February 25, 2021Applicants: TOKYO INSTITUTE OF TECHNOLOGY, NISSAN CHEMICAL CORPORATIONInventors: Yoshiaki MASAKI, Kohji SEIO, Atsushi INOUE, Yusuke IRIYAMA, Tatsuro KANAKI, Hiroyuki NAKAJIMA