Abstract: The present invention relates to an inhibitor against the stem cells of chronic myeloid leukemia (CML), a pharmaceutical composition for the treatment of CML having preventive effect on CML recurrence, a method of preventing CML recurrence, and a method of assessing the efficacy of treatment with a drug in a patient with CML, including a step of determining the expression level of latexin.

Abstract: In a treatment system, an energy treatment instrument includes a pair of grasping pieces. An energy output source outputs electric energy to the energy treatment instrument, thereby applying treatment energy to a blood vessel grasped between the grasping pieces. A measurement section measures a blood pressure at a site related to the grasped blood vessel. A processor controls output of the electric energy from the energy output source based on a measurement result obtained by the measurement section, and thereby switches an actuation state of the energy treatment instrument between a first mode for coagulating the blood vessel and a second mode for coagulating the blood vessel target that is different from the first mode.

Abstract: A treatment instrument includes a rotating body and a housing. The rotating body includes a connecting portion including: a supported portion having a cylindrical outer peripheral surface, and an engaged portion that is adjacent to the supported surface. The housing includes a supporting portion that is configured to support the supported portion of the rotating body, the supporting portion being rotatable around a predetermined rotation axis; and an engaging portion that is configured to generate a frictional force larger than a frictional force between the supporting portion and the supported portion by coming into contact with the engaged portion.

Abstract: A working machine includes a support bracket attached to a machine body, a first mounting member provided to the support bracket and formed of an elastic member, a first cooler and a second cooler arranged in parallel to a horizontal direction and mounted on the support bracket with the first mounting member, a fitting bracket detachably fitted to upper portions of the first and second coolers, and a second mounting member arranged between the fitting bracket and the first and second coolers and formed of elastic member.

Abstract: An energy treatment instrument includes a first grasping piece, and a second grasping piece which opens or closes relative to the first grasping piece and which grasps a blood vessel between the first grasping piece and the second grasping piece. In accordance with the kind of blood vessel grasped between the first grasping piece and the second grasping piece, an actuation state of the energy treatment instrument is switched between a first mode to coagulate a blood vessel of a circulatory system, and a second mode to coagulate a blood vessel of a pulmonary circulation in contrast to the first mode.

Abstract: A treatment tool includes a housing, a sheath rotatable around a predetermined axis of rotation with respect to the housing. An end effector is disposed on a distal-end portion of the sheath and rotatable in unison with the sheath around the axis of rotation. A locking member for restraining rotation of the sheath with respect to the housing by engaging the sheath. A manipulating member is mounted on the housing and moves with respect to the housing for causing the locking member and the sheath to switch between engaging and disengaging positions.

Abstract: A working machine includes a support bracket attached to a machine body, a first mounting member provided to the support bracket and formed of an elastic member, a first cooler and a second cooler arranged in parallel to a horizontal direction and mounted on the support bracket with the first mounting member, a fitting bracket detachably fitted to upper portions of the first and second coolers, and a second mounting member arranged between the fitting bracket and the first and second coolers and formed of elastic member.

Abstract: In a treatment instrument, one of a pair of jaws is supported by a supporter while being pivot able around the supporter with respect to the supporter. A drive member moves along a longitudinal axis so that the pair of the jaws are closed with respect to each other, thereby applying an axial force onto an elongated member from the drive member by way of the one of the jaws and the supporter in a direction along the longitudinal axis. A contact surface of the elongated member abuts on a housing when the elongated member moves with respect to the housing under the axial force, thereby suppressing rotation of the elongated member around the longitudinal axis with respect to the housing.

Abstract: A navigation system includes an alignment unit configured to generate corrected position information in which position information of a viewpoint of an endoscope that is inserted in a subject is aligned with a three-dimensional image of a luminal organ, a determination unit configured to determine performance/non-performance of observation of a branch conduit based on the corrected position information, a target setting unit configured to set one unobserved conduit as a first target region based on a distance between the position information of the current viewpoint and the unobserved conduit, and a navigation information generation unit configured to generate navigation information for the first target region.

Abstract: A medical equipment system includes an image pickup information storage unit configured to store images and image pickup position information by associating the images and the image pickup position information with each other; a unit configured to calculate an image pickup position in 3D information on a luminal organ during image acquisition; a control unit configured to calculate a current image pickup position or image pickup area of the image pickup system in the 3D information; and an image processing unit configured to acquire images at image pickup positions overlapping the current image pickup position or image pickup area from storage results of the image pickup information storage unit and arrange the images based on a predetermined criterion on a region by region basis.

Abstract: An energy treatment instrument includes a held unit capable of being held, and an electric-receiver-side resonator including an electric receiver coil wound around a coil axis, and resonating at the same resonance frequency as an electric-supplier-side resonator, thereby electric power being supplied from an electric supplier coil to the electric receiver coil. The energy treatment instrument includes an energy generator generating energy for use in a treatment by using the electric power supplied to the electric receiver coil, and a magnetic member including a magnetic material and located distant from the coil axis of the electric receiver coil.

Abstract: A treatment instrument includes a rotating body and a housing. The rotating body includes a connecting portion including: a supported portion having a cylindrical outer peripheral surface, and an engaged portion that is adjacent to the supported surface. The housing includes a supporting portion that is configured to support the supported portion of the rotating body, the supporting portion being rotatable around a predetermined rotation axis; and an engaging portion that is configured to generate a frictional force larger than a frictional force between the supporting portion and the supported portion by coming into contact with the engaged portion.

Abstract: A battery assembly for a medical instrument that an operator can grip by a hand and operate, includes: a battery including a first laminated body unit including a solid electrolyte layer and configured to generate electrical energy; a casing including a wall section configured to store the battery inside; and a support provided in the casing and configured to support the battery apart from the wall section in a lamination direction of the first laminated body unit.

Abstract: In a treatment instrument, one of a pair of jaws is supported by a supporter while being pivot able around the supporter with respect to the supporter. A drive member moves along a longitudinal axis so that the pair of the jaws are closed with respect to each other, thereby applying an axial force onto an elongated member from the drive member by way of the one of the jaws and the supporter in a direction along the longitudinal axis. A contact surface of the elongated member abuts on a housing when the elongated member moves with respect to the housing under the axial force, thereby suppressing rotation of the elongated member around the longitudinal axis with respect to the housing.

Abstract: A treatment tool includes a housing, a sheath rotatable around a predetermined axis of rotation with respect to the housing. An end effector is disposed on a distal-end portion of the sheath and rotatable in unison with the sheath around the axis of rotation. A locking member for restraining rotation of the sheath with respect to the housing by engaging the sheath. A manipulating member is mounted on the housing and moves with respect to the housing for causing the locking member and the sheath to switch between engaging and disengaging positions.

Abstract: A treatment tool includes a rotary member that is rotatable in unison with an elongated member such as a sheath or shaft and an end effector around a predetermined axis of rotation with respect to a housing. The rotary member includes a first ridge and a second ridge each of which projects to an outer circumferential side. The second ridge is contiguous to a distal-end side of the first ridge. A second distance from the axis of rotation to a protrusive end of the second ridge is longer than a first distance from the axis of rotation to a protrusive end of the first ridge.

Abstract: In a treatment system, an energy treatment instrument includes a pair of grasping pieces. An energy output source outputs electric energy to the energy treatment instrument, thereby applying treatment energy to a blood vessel grasped between the grasping pieces. A measurement section measures a blood pressure at a site related to the grasped blood vessel. A processor controls output of the electric energy from the energy output source based on a measurement result obtained by the measurement section, and thereby switches an actuation state of the energy treatment instrument between a first mode for coagulating the blood vessel and a second mode for coagulating the blood vessel target that is different from the first mode.

Abstract: An energy treatment instrument includes a first grasping piece, and a second grasping piece which opens or closes relative to the first grasping piece and which grasps a blood vessel between the first grasping piece and the second grasping piece. In accordance with the kind of blood vessel grasped between the first grasping piece and the second grasping piece, an actuation state of the energy treatment instrument is switched between a first mode to coagulate a blood vessel of a circulatory system, and a second mode to coagulate a blood vessel of a pulmonary circulation in contrast to the first mode.

Abstract: An endoscope system includes a portion configured to acquire a position of an objective optical system provided in an insertion portion of an endoscope; a portion configured to position the position of the objective optical system on three-dimensional image information about a subject; a portion configured to generate angle-of-view display information related to a picked-up image picked up by an image pickup system including the objective optical system; an instruction portion configured to output an instruction signal; and an image processing portion configured to create an overlapped image obtained by overlapping the angle-of-view display information at a position on the three-dimensional image information corresponding to the position of the objective optical system at a time point of inputting the instruction signal.

Abstract: A battery assembly for a medical instrument that an operator can grip by a hand and operate, includes: a battery including a first laminated body unit including a solid electrolyte layer and configured to generate electrical energy; a casing including a wall section configured to store the battery inside; and a support provided in the casing and configured to support the battery apart from the wall section in a lamination direction of the first laminated body unit.