Abstract: Methods and combination therapties for treating, preventing, and/or delaying the onset and/or development of Alzheimer's disease using an anti A? protofibril (such as, for example, BAN2401) and N-[3-((4aS,5R,7aS)-2-amino-5-methyl-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1-,3]thiazin-7a-yl)-4-fluorophenyl]-5-difluoromethylpyrazine-2-carboxamide and/or a pharmaceutically acceptable salt thereof (Compound X) are provided.

Abstract: Methods and combination therapies for treating, preventing, and/or delaying the onset and/or development of Alzheimer's disease using an anti-A? protofibril antibody (such as, for example, BAN2401) and N-[3-((4aS,5R,7aS)-2-amino-5-methyl-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl]-5-difluoromethylpyrazine-2-carboxamide and/or a pharmaceutically acceptable salt thereof (Compound X) are provided.

Abstract: Methods and combination therapies for treating, preventing, and/or delaying the onset and/or development of Alzheimer's disease using an anti-A? protofibril antibody (such as, for example, BAN2401) and N-[3-((4aS,5R,7aS)-2-amino-5-methyl-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl]-5-difluoromethylpyrazine-2-carboxamide and/or a pharmaceutically acceptable salt thereof (Compound X) are provided.

Abstract: Disclosed is a compound represented by the general formula (I) or a salt thereof: wherein any one of R1, R2 and R3 represents a group represented by the formula: —(CH2)m-NR11R12 (wherein m is 1 or 2; and R11 and R12 independently represent a hydrogen atom or a C1-6 alkyl group or may, together with a nitrogen atom to which R11 and R12 are bound, form a 4- or 5-membered cyclic group); the remaining two or R1, R2 and R3 independently represent a group represented by the formula: —(O)n-R21 (wherein n is 0 or 1; and R21 represents a hydrogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, or the like); and R4 represents a C1-6 alkyl group which may have a substituent or the like.

Abstract: An exhaust gas purification catalyst includes a catalyst layer formed on a support. The catalyst layer contains Ce-containing oxide particles having an oxygen storage/release capacity and a catalytic metal. The catalyst layer further contains a large number of iron oxide particles of 300 nm diameter or less that are dispersed therein and are in contact with the Ce-containing oxide particles. When observed by electron microscopy, the proportion of the area of iron oxide particles of 300 nm diameter or less to the total area of all of iron oxide particles in the catalyst layer is 30% or more.

Abstract: The present invention provides a hetrodiazinon compound having 2-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor antagonistic action, which is represented by the following formula (I), a pharmacologically acceptable salt thereof or hydrates thereof. Wherein A represents O, S or a group represented by the formula NR3 (wherein R3 represents hydrogen atom or a lower alkyl group); R1 and R2 are the same as or different from each other and each represents an optionally substituted (hetero)aryl group etc.; and R4 and R5 are the same as or different from each other and each represents hydrogen atom, hydroxy, a halogen atom, nitrile group, nitro group, a lower alkyl group, a (hetero)aryl group etc.

Abstract: There is provided a process to recover phthalic anhydride from a plastic material which contains a phthalate ester as a plasticizer comprising the steps of:(a) heating the plastic material so that the plastic material is gasified to produce a first product,(b) contacting the first product with alumina catalyst so that the product is catalytically cracked to produce a first catalytically cracked product comprising phthalic anhydride; and(c) recovering phthalic anhydride from the first catalytically cracked product.

Abstract: There is provided a process to recover phthalic anhydride from a plastic material which contains a phthalate ester as a plasticizer comprising the steps of:(a) heating the plastic material so that the plastic material is gasified to produce a first product,(b) contacting the first product with alumina catalyst so that the product is catalytically cracked to produce a first catalytically cracked product comprising phthalic anhydride; and(c) recovering phthalic anhydride from the first catalytically cracked product.

Abstract: A method of obtaining hydrocarbon oil from waste plastic material or waste rubber material, comprising the steps of: subjecting the waste plastic material or the waste rubber material to thermal cracking so as to obtain a thermal cracking product; liquefying the thermal cracking product into a liquefied product; causing a liquid phase cracking reaction of the liquefied product under action of a catalyst on the liquefied product so as to produce a cracking product; and cooling the cracking product so as to obtain the hydrocarbon oil, and an apparatus used for carrying out the method.