Patents by Inventor Tatsuya Higashi

Tatsuya Higashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240110922
    Abstract: An estrogen derivatization method uses a quaternary cation-containing 5-fluoro-2,4-dinitrophenyl compound represented by Formula (1): where in Formula (1), X is a quaternary cation. A mass spectrometry method includes derivatizing estrogen by the above estrogen derivatization method. A derivatization reagent derivatizing estrogen includes a quaternary cation-containing 5-fluoro-2,4-dinitrophenyl compound represented by Formula (1), where in Formula (1), X is a quaternary cation.
    Type: Application
    Filed: September 1, 2023
    Publication date: April 4, 2024
    Inventors: Tatsuya Higashi, Masaki Takiwaki, Koji Takahashi, Seketsu Fukuzawa
  • Patent number: 11718590
    Abstract: A compound represented by Chemical formula 1: wherein n is an integer of 2 or more, is provided. Also provided is a derivatization reagent for derivatizing a diene-containing compound, including a compound represented by Chemical formula 1. Further provided is a synthesis method for a compound, including a nucleophilic substitution reaction between an aryl halide and a heterocyclic amine compound being saturated, the compound being represented by Chemical formula 1.
    Type: Grant
    Filed: December 21, 2021
    Date of Patent: August 8, 2023
    Assignees: TOKYO UNIVERSITY OF SCIENCE FOUNDATION, JEOL Ltd.
    Inventors: Tatsuya Higashi, Shoujiro Ogawa, Masaki Takiwaki, Seketsu Fukuzawa
  • Publication number: 20220204459
    Abstract: A compound represented by Chemical formula 1: wherein n is an integer of 2 or more, is provided. Also provided is a derivatization reagent for derivatizing a diene-containing compound, including a compound represented by Chemical formula 1. Further provided is a synthesis method for a compound, including a nucleophilic substitution reaction between an aryl halide and a heterocyclic amine compound being saturated, the compound being represented by Chemical formula 1.
    Type: Application
    Filed: December 21, 2021
    Publication date: June 30, 2022
    Inventors: Tatsuya Higashi, Shoujiro Ogawa, Masaki Takiwaki, Seketsu Fukuzawa
  • Patent number: 11193948
    Abstract: Provided is a method for quantifying vitamin D, with the vitamin D contained in a biological sample being derivatized with a derivatization reagent and being measured with a mass spectrometer, the method including, a derivatization step of derivatizing n number of samples by using n types of 4-(4?-dimethylaminophenyl)-1,2,4-triazoline-3,5-dione (DAPTAD) isotopologues respectively as derivatization reagents, a mixing step of mixing the n types of derivatization samples obtained in the derivatization step, and a quantitative analysis step of subjecting each of the n types of vitamin D derivatives contained in the mixed sample obtained in the mixing step to quantitative analysis using a mass spectrometer.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: December 7, 2021
    Assignees: Tokyo University of Science, National University Corporation Chiba University, JEOL Ltd.
    Inventors: Tatsuya Higashi, Shoujiro Ogawa, Fumio Nomura, Mamoru Satoh, Masaki Takiwaki
  • Patent number: 10761102
    Abstract: Provided is a method for derivatizing an s-cis-diene compound with a Cookson-type derivatization reagent, the method including adding, in a reaction stopping step of stopping a derivatization reaction of the s-cis-diene compound, a decomposition inhibitor to inhibit decomposition of a derivative to be obtained.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: September 1, 2020
    Assignees: Tokyo University of Science, National University Corporation Chiba University, JEOL Ltd.
    Inventors: Tatsuya Higashi, Shoujiro Ogawa, Fumio Nomura, Mamoru Satoh, Masaki Takiwaki
  • Publication number: 20180136240
    Abstract: Provided is a method for quantifying vitamin D, with the vitamin D contained in a biological sample being derivatized with a derivatization reagent and being measured with a mass spectrometer, the method including, a derivatization step of derivatizing n number of samples by using n types of 4-(4?-dimethylaminophenyl)-1,2,4-triazoline-3,5-dione (DAPTAD) isotopologues respectively as derivatization reagents, a mixing step of mixing the n types of derivatization samples obtained in the derivatization step, and a quantitative analysis step of subjecting each of the n types of vitamin D derivatives contained in the mixed sample obtained in the mixing step to quantitative analysis using a mass spectrometer.
    Type: Application
    Filed: November 15, 2017
    Publication date: May 17, 2018
    Inventors: Tatsuya Higashi, Shoujiro Ogawa, Fumio Nomura, Mamoru Satoh, Masaki Takiwaki
  • Publication number: 20180088137
    Abstract: Provided is a method for derivatizing an s-cis-diene compound with a Cookson-type derivatization reagent, the method including adding, in a reaction stopping step of stopping a derivatization reaction of the s-cis-diene compound, a decomposition inhibitor to inhibit decomposition of a derivative to be obtained.
    Type: Application
    Filed: September 28, 2017
    Publication date: March 29, 2018
    Inventors: Tatsuya Higashi, Shoujiro Ogawa, Fumio Nomura, Mamoru Satoh, Masaki Takiwaki
  • Patent number: 6396087
    Abstract: In a circuit in which logic cells are regularly arranged, to supply to a substrate substrate potentials different from a power supply voltage and ground voltage which are supplied to sources of transistors in the cell, substrate potential supplying cells are arranged in a region in which the logic cells are arranged. The substrate potential supplying cells are connected to the substrate potentials through an n-type substrate potential NSUB line and p-type substrate potential PSUB line. The substrate potentials are supplied to apply them to the substrate. If the substrate potential lines are arranged in the logic cell region, the element area is greatly reduced. However, using the substrate potential supplying cells VSC can improve area efficiency.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: May 28, 2002
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Shinji Kitabayashi, Tatsuya Higashi, Ryoko Usuba, Junya Shirakura
  • Patent number: 6215344
    Abstract: A data transmission circuit has a push-pull circuit including first and second MOS transistors, sequentially connected in series between a first power source potential node and a second potential node, to which a first data signal and a second data signal defined as an inverted signal of the first data signal are respectively supplied, an output capacitance connected between the second power source potential node and a connecting node between the MOS transistor and the second MOS transistor which serves as an output node of the push-pull circuit, a transfer gate connected to the output node of the push-pull circuit, a first inverter connected to the output node of the transfer gate, and a second inverter connected to the first inverter to form a feedback loop, whereby the data are transmitted by a low quantity of consumed electric power.
    Type: Grant
    Filed: January 19, 1999
    Date of Patent: April 10, 2001
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Tatsuya Higashi, Kazutaka Nogami