Abstract: In masking particles comprising a drug-containing particle containing a drug of a salt with an acid and containing a carbonate, the drug-containing particle being coated with a coating layer containing a water-insoluble polymer, drug release in the oral cavity and pharynx is sufficiently suppressed, the drug is rapidly released after swallowing, and the release suppression time of the drug is easily controlled. The drug-containing particle may comprise a core particle and an interlayer on the core particle, and the core particle may contain the drug of a salt with an acid, and the interlayer contains the carbonate, or the core particle may contain the carbonate, and the interlayer may contain the drug of a salt with an acid.

Abstract: The present invention chiefly aims to provide a new API particle in which a metal or the like is coated on the API itself of a pharmaceutical solid dosage form. The present invention includes, for example, a coated API particle, wherein the surface of an API particle is coated with a metal or a metal oxide (e.g., iron oxide) by sputter deposition, and a process for manufacturing a pharmaceutical solid dosage form (e.g., tablet) using the coated API particles. According to the present invention, for example, it is possible to improve the photostability of an API itself or of pharmaceutical solid dosage forms produced with the API.

Abstract: A spherical core containing an esomeprazole compound as an active ingredient and having a median particle diameter (d50) of 50 ?m or more is coated with a coat containing a controlled release layer to prepare a controlled release granule containing a controlled release granule with a median particle diameter (d50) of 350 ?m or less. The spherical core may contain the esomeprazole compound at a proportion of 50% by mass or more relative to the spherical core. The spherical core may be a spherical particle containing the esomeprazole compound as a drug. The spherical core has a median particle diameter (d50) of 50 ?m or more. The spherical core may have a sphericity of 0.6 or more. The coat may be in a multilayer free from an esomeprazole compound as an active ingredient. The controlled release layer may be an enteric coating layer. The proportion of the coat may be 80% by mass or more relative to the whole amount of the preparation.

Abstract: Masking particles which comprise a drug-containing particle containing a drug, an acid, and a carbonate, the drug-containing particle being coated with a coating layer containing a water-insoluble polymer sufficiently suppress drug release in the oral cavity and pharynx, rapidly release a drug after swallowing, and easily control the release suppression time of a drug. The acid may be at least one organic acid. The carbonate may be at least one water-soluble carbonate. Oral pharmaceutical compositions include tablets, granules, fine granules, powders.

Abstract: The main object is to provide a novel pharmaceutical solid preparation containing a pharmaceutically active ingredient, wherein the solid preparation is coated with a light shielding agent in a nano-order thickness. The present invention can include a pharmaceutical solid preparation containing at least one pharmaceutically active ingredient, wherein the surface of the solid preparation is coated with a light shielding agent or a metal oxide to a thickness in a range of 1 nm to 500 nm to form a coating layer, or is coated with a light shielding agent or a metal oxide which is present in a range of 5×10?6 mg/mm2 to 3×10?3 mg/mm2 to form a coating layer, and a process for producing a solid preparation containing at least one pharmaceutically active ingredient, comprising a step of coating a light shielding agent or a metal oxide by sputtering on the surface of the solid preparation to a thickness in a range of 1 nm to 500 nm.

Abstract: The present invention provides a method of efficiently manufacturing drug-containing particle which has a sharp peak in the particle size distribution, is highly spherical, and good in fluidity. The present invention relates to a manufacturing method of a drug-containing particle, the drug-containing particle comprising a raw material particle and a coating layer on the outside of the raw material particle, the raw material particle and/or the coating layer comprising at least one drug, wherein the manufacturing method comprises a granulation process that agitates a mixture comprising a core particle for powder coating formed by coating the raw material particle with a polymer and a drug and/or pharmaceutically acceptable additive while spraying a solvent which can dissolve the polymer on the mixture.

Abstract: An orally disintegrating tablet combinable with a variety of drugs and exhibits excellent disintegrating properties in an oral cavity but having strength and the like allowing ability to form a tablet. The annular orally disintegrating tablet containing a drug and a disintegrating agent; and having a hole in a central portion making it annular. The content of the disintegrating agent relative to total weight is 2% to 50% by weight. It exhibits excellent disintegrating properties, i.e., when a gradient of disintegrating time (seconds) of the tablet with respect to tableting pressure (kN) upon compression-forming is defined as “a” and a gradient of disintegrating time (seconds) of a disk-shaped orally disintegrating tablet with respect to tableting pressure (kN) upon compression-forming is defined as “b”, the disk-shaped orally disintegrating tablet having the same weight and external diameter as the annular orally disintegrating tablet the ratio (a/b) is 0.90 or less.