Abstract: The present invention provides a thermal cycler capable of rapidly and efficiently heating and cooling a reaction liquid. The thermal cycler according to the present invention comprises: a temperature control block where a reaction vessel can be installed, a thermoelectric conversion unit capable of heating and cooling, a temperature sensor that measures the temperature of the temperature control block, an insulating substrate that is in contact at one surface with the thermoelectric conversion unit, and a heat radiating unit that is provided on the other surface of the insulating substrate and serves for discharging the heat of the thermoelectric conversion unit to the outside, wherein the temperature control block is heated and cooled by controlling a current or voltage supplied to the thermoelectric conversion unit on the basis of the temperature of the temperature adjustment block measured by the temperature sensor.

Abstract: The purpose of the present invention is to provide a temperature control device (1) capable of changing the temperature of a temperature regulating block (2) rapidly and with high accuracy. A temperature control device (1) according to the present invention is provided with: the temperature regulating block (2), on which a container (5) accommodating a solution (6) can be placed; and a temperature regulating part (3) that is installed so as to contact the temperature regulating block (2) and that changes the temperature of the solution (6), wherein the temperature regulating block (2) is provided with, on the inside thereof, one or a plurality of hollow parts (7).

Abstract: A temperature control device has: a sample container holder that holds a sample container; multiple temperature sensors that measure the temperature near a sample; a temperature control element that heats or cools the sample container holder; a storage unit that stores a mathematical model; and a computation unit that analyzes the mathematical model based on the sensors. The mathematical model serves as a thermal network model in which nodes and a thermal resistance between predetermined nodes are set, the nodes corresponding at least to the sample, sample container, sample container holder, sensors, and temperature control element. Each node has a predetermined heat capacity, and the computation unit uses a state estimation algorithm to calculate a thermal resistance estimated value between the sample container and the sample container holder and a temperature estimated value of the sample, based on the output from each of the sensors and the thermal network model.