Patents by Inventor Tatsuya Kosako
Tatsuya Kosako has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11656223Abstract: In a method of detecting a test substance, a test substance is detected using a sample analysis cartridge supplied with a sample. The sample analysis cartridge includes: a passage part having a gas-phase space; and liquid containers communicating with the passage part through openings. The liquid containers include: a first liquid container containing a first liquid containing magnetic particles; and a second liquid container containing a second liquid containing a labeled substance. The magnetic particles are sequentially transported to the liquid containers through the gas-phase space in the passage part. Thus, the magnetic particles carry a complex of the test substance and the labeled substance. The test substance is detected based on the labeled substance in the complex.Type: GrantFiled: June 24, 2021Date of Patent: May 23, 2023Assignee: SYSMEX CORPORATIONInventors: Kazuyoshi Horii, Tomoyuki Nose, Takao Fujiwara, Tatsuya Kosako
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Publication number: 20210318297Abstract: In a method of detecting a test substance, a test substance is detected using a sample analysis cartridge supplied with a sample. The sample analysis cartridge includes: a passage part having a gas-phase space; and liquid containers communicating with the passage part through openings. The liquid containers include: a first liquid container containing a first liquid containing magnetic particles; and a second liquid container containing a second liquid containing a labeled substance. The magnetic particles are sequentially transported to the liquid containers through the gas-phase space in the passage part. Thus, the magnetic particles carry a complex of the test substance and the labeled substance. The test substance is detected based on the labeled substance in the complex.Type: ApplicationFiled: June 24, 2021Publication date: October 14, 2021Applicant: SYSMEX CORPORATIONInventors: Kazuyoshi HORII, Tomoyuki NOSE, Takao FUJIWARA, Tatsuya KOSAKO
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Patent number: 11073514Abstract: In a method of detecting a test substance, a test substance is detected using a sample analysis cartridge supplied with a sample. The sample analysis cartridge includes: a passage part having a gas-phase space; and liquid containers communicating with the passage part through openings. The liquid containers include: a first liquid container containing a first liquid containing magnetic particles; and a second liquid container containing a second liquid containing a labeled substance. The magnetic particles are sequentially transported to the liquid containers through the gas-phase space in the passage part. Thus, the magnetic particles carry a complex of the test substance and the labeled substance. The test substance is detected based on the labeled substance in the complex.Type: GrantFiled: September 19, 2019Date of Patent: July 27, 2021Assignee: SYSMEX CORPORATIONInventors: Kazuyoshi Horii, Tomoyuki Nose, Takao Fujiwara, Tatsuya Kosako
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Publication number: 20200011861Abstract: In a method of detecting a test substance, a test substance is detected using a sample analysis cartridge supplied with a sample. The sample analysis cartridge includes: a passage part having a gas-phase space; and liquid containers communicating with the passage part through openings. The liquid containers include: a first liquid container containing a first liquid containing magnetic particles; and a second liquid container containing a second liquid containing a labeled substance. The magnetic particles are sequentially transported to the liquid containers through the gas-phase space in the passage part. Thus, the magnetic particles carry a complex of the test substance and the labeled substance. The test substance is detected based on the labeled substance in the complex.Type: ApplicationFiled: September 19, 2019Publication date: January 9, 2020Applicant: SYSMEX CORPORATIONInventors: Kazuyoshi HORII, Tomoyuki NOSE, Takao FUJIWARA, Tatsuya KOSAKO
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Patent number: 10473652Abstract: In a method of detecting a test substance, a test substance is detected using a sample analysis cartridge supplied with a sample. The sample analysis cartridge includes: a passage part having a gas-phase space; and liquid containers communicating with the passage part through openings. The liquid containers include: a first liquid container containing a first liquid containing magnetic particles; and a second liquid container containing a second liquid containing a labeled substance. The magnetic particles are sequentially transported to the liquid containers through the gas-phase space in the passage part. Thus, the magnetic particles carry a complex of the test substance and the labeled substance. The test substance is detected based on the labeled substance in the complex.Type: GrantFiled: March 25, 2016Date of Patent: November 12, 2019Assignee: SYSMEX CORPORATIONInventors: Kazuyoshi Horii, Tomoyuki Nose, Takao Fujiwara, Tatsuya Kosako
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Patent number: 10393765Abstract: Disclosed is a measurement apparatus including: a support mechanism configured to support a cartridge in which a chamber is formed, the chamber being configured to store a measurement sample that generates light an intensity of which varies depending on an amount of a test substance; a photodetector configured to detect the light generated from the measurement sample stored in the chamber; and a reflection member provided between the photodetector and the cartridge supported by the support mechanism, the reflection member having an inner face, the reflection member being configured to reflect, at the inner face, the light generated from the measurement sample stored in the chamber, and guide the light to the photodetector, wherein the reflection member is configured to have an area surrounded by the inner face, the area decreasing from a side where the cartridge supported by the support mechanism is provided toward a side where the photodetector is provided.Type: GrantFiled: June 29, 2017Date of Patent: August 27, 2019Assignee: SYSMEX CORPORATIONInventors: Takao Fujiwara, Kazuyoshi Horii, Tatsuya Kosako, Tomoyuki Nose, Sayuri Tomoda
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Publication number: 20180003732Abstract: Disclosed is a measurement apparatus including: a support mechanism configured to support a cartridge in which a chamber is formed, the chamber being configured to store a measurement sample that generates light an intensity of which varies depending on an amount of a test substance; a photodetector configured to detect the light generated from the measurement sample stored in the chamber; and a reflection member provided between the photodetector and the cartridge supported by the support mechanism, the reflection member having an inner face, the reflection member being configured to reflect, at the inner face, the light generated from the measurement sample stored in the chamber, and guide the light to the photodetector, wherein the reflection member is configured to have an area surrounded by the inner face, the area decreasing from a side where the cartridge supported by the support mechanism is provided toward a side where the photodetector is provided.Type: ApplicationFiled: June 29, 2017Publication date: January 4, 2018Inventors: Takao FUJIWARA, Kazuyoshi HORII, Tatsuya KOSAKO, Tomoyuki NOSE, Sayuri TOMODA
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Patent number: 9752989Abstract: A sample analyzing method for suppressing an adverse effect on detection accuracy of a detection target substance is disclosed. In the sample analyzing method, a magnetic particle as a support of a detection target substance is transported by magnetic force to a second liquid container through a passage between a first liquid container storing a first liquid containing the magnetic particle and the second liquid container storing a second liquid containing a labeled substance to forma complex with the detection target substance and the magnetic particle. The complex formed in the second liquid container and containing the detection target substance, magnetic particle, and labeled substance is transported to a third liquid in a flow path, and the magnetic particle is transported to a detection tank for detecting the detection target substance, while being agitated in a mixed liquid of the complex and third liquid within the flow path.Type: GrantFiled: March 28, 2016Date of Patent: September 5, 2017Assignee: SYSMEX CORPORATIONInventors: Kazuyoshi Horii, Tomoyuki Nose, Tatsuya Kosako
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Publication number: 20160320307Abstract: A sample analyzing method for suppressing an adverse effect on detection accuracy of a detection target substance is disclosed. In the sample analyzing method, a magnetic particle as a support of a detection target substance is transported by magnetic force to a second liquid container through a passage between a first liquid container storing a first liquid containing the magnetic particle and the second liquid container storing a second liquid containing a labeled substance to forma complex with the detection target substance and the magnetic particle. The complex formed in the second liquid container and containing the detection target substance, magnetic particle, and labeled substance is transported to a third liquid in a flow path, and the magnetic particle is transported to a detection tank for detecting the detection target substance, while being agitated in a mixed liquid of the complex and third liquid within the flow path.Type: ApplicationFiled: March 28, 2016Publication date: November 3, 2016Applicant: SYSMEX CORPORATIONInventors: Kazuyoshi HORII, Tomoyuki NOSE, Tatsuya KOSAKO
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Publication number: 20160320375Abstract: In a method of detecting a test substance, a test substance is detected using a sample analysis cartridge supplied with a sample. The sample analysis cartridge includes: a passage part having a gas-phase space; and liquid containers communicating with the passage part through openings. The liquid containers include: a first liquid container containing a first liquid containing magnetic particles; and a second liquid container containing a second liquid containing a labeled substance 42. The magnetic particles are sequentially transported to the liquid containers through the gas-phase space in the passage part. Thus, the magnetic particles carry a complex of the test substance and the labeled substance. The test substance is detected based on the labeled substance in the complex.Type: ApplicationFiled: March 25, 2016Publication date: November 3, 2016Applicant: SYSMEX CORPORATIONInventors: Kazuyoshi HORII, Tomoyuki NOSE, Takao FUJIWARA, Tatsuya KOSAKO
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Patent number: 6713019Abstract: A flow cytometer includes a flow cell for flowing a sample liquid in a flowing direction, to form a sample flow the sample liquid containing particles to be analyzed, a laser diode radiating a laser beam having an elliptic cross section, a beam collimating section for collimating the laser beam radiated from the laser diode, a beam spot forming section for focusing the collimated beam at the sample flow in the flow cell to form a beam spot, and a light receiving section for receiving light generated from the particles at the beam spot to detect optical information of the particles, wherein the laser diode is arranged such that a minor diameter of the elliptic section of the laser beam is parallel to the sample flow.Type: GrantFiled: March 27, 2002Date of Patent: March 30, 2004Assignee: Sysmex CorporationInventors: Masatsugu Ozasa, Tatsuya Kosako
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Publication number: 20020141902Abstract: A flow cytometer includes a flow cell for flowing a sample liquid in a flowing direction, to form a sample flow the sample liquid containing particles to be analyzed, a laser diode radiating a laser beam having an elliptic cross section, a beam collimating section for collimating the laser beam radiated from the laser diode, a beam spot forming section for focusing the collimated beam at the sample flow in the flow cell to form a beam spot, and a light receiving section for receiving light generated from the particles at the beam spot to detect optical information of the particles, wherein the laser diode is arranged such that a minor diameter of the elliptic section of the laser beam is parallel to the sample flow.Type: ApplicationFiled: March 27, 2002Publication date: October 3, 2002Inventors: Masatsugu Ozasa, Tatsuya Kosako
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Patent number: 5527714Abstract: Particle size distributions with greatly improved accuracy are prepared for diagnostic analysis using antigen/antibody reactions to concentrate sensitized insoluble carriers into non-aggregated and aggregated particles of known size. The analyte is analyzed by an electronic analyzer to determine the quantity and size distribution of concentrated non-aggregated and aggregated insoluble carriers resulting from the antigen/antibody reaction, as well as spurious particles that may be present in the analyte. The concentrated non-aggregated and aggregated insoluble carriers occur in known regions of the measured size distribution. The spurious particles exist throughout the size distribution. The distribution of spurious particles is determined in the regions where the desired particles are known to be absent. A complete distribution of spurious particles is constructed by interpolation using a cubic spline function.Type: GrantFiled: August 1, 1994Date of Patent: June 18, 1996Assignee: Toa Medical Electronics Co., Ltd.Inventor: Tatsuya Kosako