Abstract: A medicinal oral preparation to be delivered to the large intestine comprising a core containing a pharmacologically active ingredient, an inner layer containing one or more cationic polymers and an outer layer containing one or more anionic polymers whereby the core is coated, which is designed so that, in a disintegration test successively consisting of a vertical movement for 2 hours in a first solution of pH 1.2, a vertical movement for 2 hours in a second solution of pH 7.4 and a vertical movement in a third solution of pH 6.4, the average disintegration initiation point and the average disintegration completion point each falls within a period from 35 minutes to 130 minutes after starting the vertical movement in the third solution.

Abstract: The object of the present invention is to provide an iontophoresis electrode device with superior performance which avoids entrance of metal ions from the electrode into the body, is reusable and can be mass produced at low cost, minimizes gas generation which causes polarization, can notably improve transport current, and can prevent skin injury by pH changes during prolonged application. The iontophoresis electrode device of the present invention has a construction provided with a backing 1 having an edge section 1a around an opening and a packing chamber 4 inside, an electrode terminal 2 situated in the packing chamber 4, a non-adhesive gel 5 containing an electrolyte solvent, depolarizer, pH regulator and drug packed in the packing chamber 4, an inert electrode member 3 covering the base of the electrode terminal 2, and a liner 7 attached to the adhesive layer 6 coated on the edge section 1a and covering the opening.

Abstract: Disclosed are cholesterol-depressant, coated or non-coated tablets for oral administration, which comprise an anion exchange resin of formula (I): wherein X represents a physiologically-acceptable counter ion; and p represents an average degree of polymerization, and is larger than 10,000, silicon dioxide and crystalline cellulose, but not containing water. The non-coated tablets are preferably coated with cellulosic substances. The tablets are easy to take, as being not bitter. The dose of the tablets can be decreased, since the tablets can contain a large amount of the active ingredient. The mixture comprising the constituent components can be directly tabletted in the absence of water.

Abstract: The present invention relates to a pharmaceutical composition comprising anion exchange resin, silicon dioxide, crystalline cellulose, and pharmaceutically acceptable carriers and more particularly to tablets containing anion exchange resin prepared by mixing anion exchange resin, silicon dioxide and crystalline cellulose without adding water and tabletting the mixture. More preferably, the present invention relates to said pharmaceutical composition or tablets wherein the anion exchange resin is non-crosslinked anion exchange resin represented by the formula (I): ##STR1## wherein R.sub.1 is an aralkyl group having from 7 to 10 carbon atoms or An alkyl group having from 1-20 carbon atoms; R.sub.2 and R.sub.3 are each independently the same or different and represent a lower alkyl group having from 1-4 carbon atoms; R.sub.

Abstract: An iontophoretic device structure of the dissolution-on-use type is provided, wherein an ionized drug is transdermally or transmucosally administered into a living body. The device structure comprises (a) a non-polarizable electrode, (b) a hydrophilic, polymeric gel layer containing an ion exchange resin which is able to specifically inhibit the movement of ions dissolved out from the electrode while in use, and (c) a drug layer containing a drug in a dry condition in a drug retaining membrane, wherein when said device is in use, said drug layer is brought into contact with said hydrophilic, polymeric gel layer so that said drug in the dry condition is dissolved. A humectant may be contained in the hydrophilic, polymeric gel layer and/or the drug layer.